the community site for and by developmental biologists

The people behind the papers – Guillaume Blin, Manuel Thery & Sally Lowell

Posted by on September 21st, 2018

During early mouse development, a series of signalling interactions breaks the symmetry of the egg cylinder, spatially organising the embryo into territories that define the future axes of the body. Symmetry breaking can also be observed in embryonic stem cell (ESC) colonies cultured on micropatterned substrates, which thus provide a powerful system to test the[…]

Revisiting an old puzzle with high-resolution, three-dimensional eyes

Posted by on September 19th, 2018

Sha Wang, Deborah Gumucio This article shares the story behind our recent Developmental Cell paper. It tells the history of this project and how three-dimensional (3D) observations at the individual cell level transformed our preconceived ideas and brought new insights into cell dynamics in the proliferative intestinal epithelium.   Epithelial tubes are present in many[…]

Nora and Nestor catch you up with the BSDB Autumn Meeting 2018

Posted by on September 19th, 2018

  Hello there! This is Nora Braak and Nestor Saiz, we are based in Oxford and New York respectively and we study butterfly and mouse development. Last week we went to the BSDB Autumn meeting, which also happened to be the third workshop on Embryonic Extraembryonic Interactions. We enjoyed it so much that we wanted[…]

Organ plumbing

Posted by on September 19th, 2018

Water is a fascinating substance. Its behavior sets a lot of interesting constraints on both how the surface of our world is shaped geologically and how life on said surface has adapted to optimize its use. Biology and geology, while vastly different in scale, share many commonalities that can we can learn from. Our work[…]

Salamander Models in Cross-Disciplinary Research – Meeting Report

Posted by on September 18th, 2018

  Vienna, Austria July 2018     The use of salamanders in regeneration and developmental research has a long history filled with luminaries of the life sciences. Thomas Hunt Morgan, Hans Spemann and Hilde Mangold, Ross Granville Harrison, Inez Whipple Wilder, and August Weismann all employed salamanders in their work 1,2. Current experimental research on[…]

This month in preLights – August

Posted by on September 5th, 2018

Welcome to our monthly summary of developmental biology (and related) preLights.   preLighters are early-career researchers who select and highlight preprints which they feel are interesting for the life-science community. While writing highlight posts is mostly an individual effort, plenty of interactions between the preLights team members take place on our Slack channel. This is[…]

Publishing peer review reports

Posted by on September 5th, 2018

Last week, Development and our sister journal Journal of Cell Science signed an open letter coordinated by ASAPbio, signalling our intention to publish peer review reports alongside published papers. I’m really delighted to be making this commitment and wanted to take the opportunity to say a few words about our thinking behind this decision. So[…]

The people behind the papers – Jaqueline Kinold & Hermann Aberle

Posted by on September 4th, 2018

Axon guidance relies on the reception and integration of molecular cues from the environment by growth cones, and defective pathfinding results in misplaced projection patterns in the mature nervous system. A new paper in Development investigates this process in the Drosophila neuromucular system, as well as the consequences of axonal miswiring to locomotion. We caught up[…]

August in preprints

Posted by on September 3rd, 2018

Welcome to our monthly trawl for developmental biology (and other related/just plain cool) preprints.    This month we found a tonne of  papers dealing with various aspects of inheritance in worms, a flush of fly mechanics, and more single cell sequencing than you could shake a stick at. And as summer draws to a close, it’s raining[…]