the community site for and by developmental biologists

Glia lead the way for pioneers to build the brain neuropil in C. elegans

Posted by on October 20th, 2017

It’s all about the wires. But what about the glue? Networks make us who we are. I am not talking about social networks but about neural networks that define how we perceive the world and how we act. For a century, neuroscientists have sought to understand functions of neural networks in condition and how such[…]

Guidelines for morpholino use in zebrafish

Posted by on October 20th, 2017

If you work with zebrafish or Morpholinos, please read this. Guidelines for morpholino use in zebrafish. Stainier DYR, Raz E, Lawson ND, Ekker SC, Burdine RD, Eisen JS, Ingham PW, Schulte-Merker S, Yelon D, Weinstein BM, Mullins MC, Wilson SW, Ramakrishnan L, Amacher SL, Neuhauss SCF, Meng A, Mochizuki N, Panula P, Moens CB. PLoS[…]

The right information

Posted by on October 19th, 2017

Oscar H. Ocaña and M. Angela Nieto Comment on “A right-handed signalling pathway drives heart looping in vertebrates”. Nature 549, 86-90 (2017).   A fundamental aspect of vertebrates is their external bilateral symmetry, which has to some extent shaped evolutionary success. Not only is beauty associated with symmetry, enhancing an individual’s chance of mating but[…]

The people behind the papers – Sabrina Jan, Tinke Vormer, Sjoerd Repping and Ans MM van Pelt

Posted by on October 18th, 2017

During spermatogenesis, progenitor cells must undergo tightly regulated changes to produce functional gametes. However, the genetic control of this process in humans has eluded researchers. This week we feature a paper published in the latest issue of Development that describes the changing genetic expression of cell during spermatogenesis. The co-first authors Sabrina Jan and Tinke[…]

Forgotten classics: Making a monotreme

Posted by on October 17th, 2017

T. Thomson Flynn and J.P. Hill. 1939. The Development of the Monotrema – Part IV. Growth of the Ovarian Ovum, Maturation, Fertilisation and Early Cleavage. Transactions of the Zoological Society of London, 24, 445-623. T. Thomson Flynn and J.P. Hill. 1947. The Development of the Monotrema – Part VI. The Later Stages of Cleavage and[…]

In Development this week (Vol. 144, Issue 20)

Posted by on October 17th, 2017

Here are the highlights from the current issue of Development:   Sequencing sheds light on human spermatogenesis In order to produce sperm, progenitor germ cells in the testes must undergo mitosis, meiosis, differentiation, and alter their chromatin structure to give rise to functional gametes. Much of our knowledge about how this complex process is controlled[…]

Adhesion and signaling by Collagen IV intercellular concentrations (CIVICs)

Posted by on October 16th, 2017

The Great Wall of Collagen IV During the long history of evolution, the key innovation that gave rise to animals with true tissues was the extracellular matrix, very conserved from sponges to humans [1]. Before I started my PhD in the lab of Jose C. Pastor-Pareja at Tsinghua University in Beijing, he had described how[…]

Switch the career after PhD

Posted by on October 16th, 2017

Dear Colleagues, I am PhD graduate in Biotechnology focusing on Insect Molecular Biology and Plant Virology. After completion of my PhD in Agriculture sector, I would like to switch my career to medical sciences or advance biotech tools like studies in stem cells, or CRISPR. Should I repeat PhD in medical sciences or is there[…]

A 10-Step “Protocol” for Antibody Search

Posted by on October 12th, 2017

I remember when I first started grad school. I was pumped about my project, examining the signaling and physiological role of a novel dopamine receptor complex. We had experienced research associates, state-of-the-art equipment, and bold hypotheses. I was ready to take the first step on the road of biomedical discoveries. Then I faced my first[…]