the community site for and by developmental biologists

A day in the life of an embryonic stem cell lab!

Posted by on February 5th, 2016

Hi everyone! I’m Helena. Some of you may know me as the current intern here at the Node, but next week, I will go back to Alfonso Martínez Arias’ lab at the University of Cambridge to continue working on my PhD. Our lab is interested in cell fate and differentiation in the context of early[…]

Pluripotency in the mouse and beyond…

Posted by on February 4th, 2016

Preimplantation development establishes the founding cell population of the adult mammal in the epiblast. This naïve pluripotent state employs a unique hand of transcription factors to ensure epigenetic resetting and unbiased embryonic potential. In rodents, naïve pluripotency can be captured in the form of embryonic stem (ES) cells1-4, however other mammals have proven more refractory.[…]

Woods Hole images 2015 round 1- the winner

Posted by on February 4th, 2016

And the winner of the latest round of images from the Woods Hole embryology course is… the short-tailed fruit bat embryo!   Here are the full results: – Pig embryo: 102 votes – Longfish inshore squid embryo: 67 votes – Short-tailed  fruit bat embryo: 296 votes – Mouse embryo: 129 votes       Many[…]

another attempt to widen access

Posted by on February 3rd, 2016

Sorry for all the messing about, but there are now a number of ways of accessing  my latest polemic which is called The last 50 years: mismeasurement and mismanagement are impeding scientific research. Here is one http://making-of-a-fly.me/files/pdf/Lawrence-2016.pdf   (No Ratings Yet) Loading…

Using the mouse to model human disease: increasing validity and reproducibility

Posted by on February 3rd, 2016

This editorial by Monica J. Justice and Paraminder Dhillon was first published in Disease Models & Mechanisms.   ABSTRACT Experiments that use the mouse as a model for disease have recently come under scrutiny because of the repeated failure of data, particularly derived from preclinical studies, to be replicated or translated to humans. The usefulness of[…]

Green Glow the Salamanders

Posted by on February 3rd, 2016

This is an terrific Shelf Life video made by Erin Chapman at the American Museum of Natural History. It features our work on a symbiosis between the classic model salamander Ambystoma maculatum and its algal symbiont, Oophila amblystomatis.   (No Ratings Yet) Loading…

21st Century Journal Clubs

Posted by on February 2nd, 2016

Does anyone have 21st century ideas on how to run a diverse (not just developmental biology) departmental journal club? (No Ratings Yet) Loading…

Growth and regeneration – what’s the common thread?

Posted by on February 2nd, 2016

Last week, I attended the Keystone Symposium “Molecular and cellular basis of growth and regeneration”. This outstanding meeting was the second incarnation of a Keystone meeting on regeneration; the first having been held in 2012 – Development reviewed it here. The expansion in scope of this year’s meeting to encompass both growth and regeneration was,[…]

In Development this week (Vol. 143, Issue 3 )

Posted by on February 2nd, 2016

Here are the highlights from the current issue of Development:   New insights into human neural crest induction Human neural crest (NC) cells are the precursors for a wide range of ectodermal and mesenchymal cell derivatives. Due to the inherent difficulties associated with early human embryonic studies, it is currently unclear exactly when NC cells[…]