the community site for and by developmental biologists

The people behind the papers – Ximena Anleu Gil & Dominique Bergmann

Posted by on July 18th, 2018

Asymmetric division is a widespread mechanism for generating cellular diversity during developmental patterning. The stomata of flowering plants are epidermal valves that regulate gas exchange, and provide an accessible system to investigate the mechanisms of asymmetric cell division both within and across species. A paper in the new issue of Development reports an investigation of the molecular control of this[…]

Evo-chromo: towards an integrative approach of chromatin dynamics across eukaryotes

Posted by on July 18th, 2018

***Deadline to apply for funded ECR places is July 20!***   In November, the Company of Biologists is hosting the latest in its series of Workshops. ‘Evo-chromo’ aims to integrate skills and interests of the fields of chromatin biology and evolutionary biology – if you are an early career researcher and this all sounds appealing[…]

Differentiating cells mechanically limit progenitor cells’ interkinetic nuclear migration to secure apical cytogenesis

Posted by on July 17th, 2018

Press release for Yuto Watanabe, Takumi Kawaue and Takaki Miyata‘s new Development paper   Key Points Developing brains use a mechanism like the Otoshi-buta (the drop lid), a kitchen wisdom. Differentiating cells in embryonic cerebral walls form a dense filter-like layer to mechanically barrier nuclei of neural stem cells. Loss of this barrier or fence results in[…]

NC3Rs 2019 Funding Highlight Notice Launch

Posted by on July 13th, 2018

The National Centre for the Replacement, Refinement and Reduction of Animals in Research (NC3Rs) is running a workshop bringing together rodent and non-mammalian model organism users, facilitating research partnerships and encouraging the development of new and innovative applications of non-mammalian organisms.     There will be an opportunity to: Hear from rodent and non-mammalian model organism users. Learn[…]

A day in the life of a Capitella teleta lab

Posted by on July 10th, 2018

It’s undoubtedly the middle of summer here in Saint Augustine, Florida. Daily temperatures are soaring into the 90s, and we’re grateful if the humidity dips below 70%. Thankfully, the Seaver lab doesn’t have to contend with much of this heat. Instead, our members are inside, comfortable though busier than ever, mentoring summer interns, piloting new[…]

All beauty must die

Posted by on July 9th, 2018

Anna Daneva, Zhen Gao and Moritz Nowack tell the story behind their recent paper in Nature Plants   The transience of flowers is proverbial. Degeneration of flowers is elicited after successful pollination by the onset of seed and fruit development. However, also unpollinated flowers do not last forever – on the contrary, the life span[…]

C. elegans Development, Cell Biology and Gene Expression and 2018 European Worm Meeting report

Posted by on July 9th, 2018

I recently attended the biennial Development, Cell Biology and Gene Expression C. elegans Meeting, this time in combination with the 2018 European Worm Meeting, in Barcelona. C. elegans meetings are always pretty special, defined more than anything else by the strong sense of community between researchers, or, as well like to call ourselves, ‘Worm People’.[…]

Stem cell makes its own niche: the story behind the paper

Posted by on July 7th, 2018

In our recent paper published in Nature, we unravel a new mechanism of an extracellular matrix protein secreted by muscle satellite (stem) cells, thereby playing the unusual role of acting as a signaling molecule to maintain the stem cell population. Here, I share the story behind this discovery and discuss the questions related to niche[…]

The people behind the papers – Martina Nagel & Rudolf Winklbauer

Posted by on July 6th, 2018

Contact inhibition of locomotion is a widespread phenomenon in migrating cells. However, cells often migrate collectively as a sheet, raising the question of how contact inhibition is overcome in these scenarios. A new paper in Development addresses this problem by studying the signals that regulate collective migration in Xenopus leading edge mesendoderm (LEM) cells. We[…]