the community site for and by developmental biologists

2nd International FishMed Conference on Zebrafish Research (FishMed2018)

Posted by on August 18th, 2017

Dear Researchers, it is our great pleasure to announce the 2nd International FishMed Conference on Zebrafish Research (FishMed2018), which will be held on March 25-27, 2018 at the International Institute of Molecular and Cell Biology in Warsaw (IIMCB), Poland. We organize this event to share with you the most recent knowledge and developments in zebrafish research[…]

An interview with Jenny Nichols

Posted by on August 17th, 2017

This interview by Aidan Maartens originally appeared in Development, Volume 143, Issue 16. Jennifer Nichols is a Principal Investigator at the Cambridge Stem Cell Institute and Department of Physiology, Development and Neuroscience at the University of Cambridge, UK. Her lab works on lineage segregation and the establishment of pluripotency in the mammalian embryo. In 2017 she was[…]

The people behind the papers: Alaa Hachem and John Parrington

Posted by on August 16th, 2017

Embryogenesis begins with fertilisation, and defective activation of the egg by the sperm is implicated in human infertility. Today’s paper, published in the most recent issue of Development, investigates the role of the sperm protein PLCζ in egg activation and the calcium oscillations that accompany it. We caught up with co-first author Alaa Hachem and his[…]

On Growth and Form centenary conference

Posted by on August 15th, 2017

The full programme and booking information for the On Growth and Form 100 conference are now online at https://www.ongrowthandform.org/conference/ The three-day conference takes place in the University of Dundee and the University of St Andrews on 13-15 October and features speakers from around the world, exploring the many aspects and influences of D’Arcy Thompson’s landmark[…]

In Development this Week (Vol. 144, Issue 15)

Posted by on August 15th, 2017

Here are the highlights from the current issue of Development:   PLCζ ‘waves in’ mammalian oocyte activation At fertilisation, fusion of the sperm with the oocyte activates a slew of downstream processes to kick-start embryogenesis. This ‘oocyte activation’ event induces the cortical reaction to prevent polyspermy, triggers oocyte metabolic and DNA synthesis pathways, and reactivates meiosis. In[…]

Baby cichlids working out their jaws

Posted by on August 14th, 2017

I joined Dr. Craig Albertson’s lab as a graduate student in 2009, where I quickly became fascinated by these cute cichlid fishes. They’re colorful, they breed their young in the mouth, and some of them have funny looking faces like this blue mbuna (Labeotropheus fuelleborni):     My research started on the genetic control of[…]

Discovery Through Collaboration: Brain Lymphatic Endothelial Cells

Posted by on August 8th, 2017

Looking back on the journey: Intracellular uptake of macromolecules by brain lymphatic endothelial cells during zebrafish embryonic development eLife van Lessen et al., 2017   Just over two years ago, while I was a Masters of Neuroscience student at University College London, I became interested in the emerging concepts of brain lymphatics and sleep dependent macromolecule[…]

Making time matter: how hormone pulses direct chromatin accessibility during development

Posted by on August 8th, 2017

Each of our cells has the same genetic information and thus the same potential to become a part of a heart, brain, or a finger. Somehow though, during development our cells manage to figure out exactly which type of cell they should be and which body parts they should help compose. The key to making[…]

Workshop on HREM imaging and mouse phenotyping

Posted by on August 8th, 2017

Deciphering the Mechanisms of Developmental Disorders (DMDD) is a large-scale imaging and phenotyping  programme for genetically modified mouse embryos. For embryos at E14.5, the key imaging technique is High Resolution Episcopic Microscopy (HREM), and the resulting images are used to comprehensively phenotype the embryos using a systematic approach.     With a combination of lectures,[…]