the community site for and by developmental biologists

ISSCR 2017 Award Winners Announced

Posted by on February 16th, 2017

Each year the International Society for Stem Cell Research (ISSCR) recognises the stem cell researchers driving the field forward in their annual awards. You can learn more about the awards here, and watch short videos of the awardees discussing their work below.   Elaine Fuchs McEwen Award for Innovation    Jayaraj Rajagopal Dr. Susan Lim Outstanding Young[…]

The people behind the papers #14

Posted by on February 15th, 2017

Embryonic stem cells express genes necessary for self-renewal, and also ‘prime’ lineage-specific genes which stay silent until differentiation; the molecular players and pathways that govern the timely gene expression are still being delineated. Today’s paper comes from the most recent issue of Development and reveals a role for the histone demethylase Jmjd2c in gene activation in stem cell[…]

Meet Our Scientists VIDEO: Marco Milán: “To study how cells communicate with each other, perhaps the best model organism is the fruit fly”

Posted by on February 15th, 2017

The “Meet Our Scientists” video entitled “Our relative the fly” presents the research performed by Marco Millán on the cellular and molecular mechanisms underlying the regulation of tissue growth during normal development, tissue homeostasis, and tumorigenesis.     Marco Milán, ICREA research professor, leads the Development and Growth Control Laboratory at IRB Barcelona. In the[…]

Gene editing stem cells with CRISPR could help understand brain tumours

Posted by on February 14th, 2017

This report written by Justine Alford and highlighting a recent Development paper originally appeared on the CRUK Science Blog.      Over the past 12 months, the acronym CRISPR has been popping up in science news left, right and centre. And for good reason. Hailed as a revolution in genetic engineering, this molecular toolbox lets[…]

Uncovering Non-canonical Roles of E-cadherin Beyond Cell Adhesion

Posted by on February 14th, 2017

Broad perspective Successful division was an essential criterion for establishing the cell as the basic unit of life on earth. Later, cell-cell adhesion made possible the evolution of multicellular life forms. These two fundamental cellular processes co-function throughout the life of an organism, during development, wound healing and tissue regeneration. In epithelial tissues this results[…]

In Development this week (Vol. 144, Issue 4)

Posted by on February 14th, 2017

Here are the highlights from the new issue of Development:   A new mechanism in ESC lineage priming Histone demethylases have recognized roles in the control of gene expression during development and disease, and are typically associated with the remodelling of the chromatin environment. Jmjd2/Kdm4 H3K9-demethylases cooperate in promoting mouse embryonic stem cell (ESC) identity,[…]

Meeting review: BSDB/Anne McLaren Memorial Trust 2016 Autumn Meeting

Posted by on February 10th, 2017

The use of chimaeras to study developmental mechanisms: from lineage tracing to disease models   Under the sponsorship of the Anne McLaren Memorial Trust Fund and The Company of Biologists, the BSDB Autumn meeting organised by Jenny Nichols and Tristan Rodriguez took place in the Pollock Halls at the University of Edinburgh. The topic this[…]

Transposons in Embryo Space – TRACER maps in EMAGE

Posted by on February 9th, 2017

A recent publication in Developmental Biology by (Armit et al., 2017) describes how the TRACER dataset can be spatially compared with in situ hybridisation gene expression profiles.   The TRACER dataset of transposon-associated regulatory sensors (Chen et al., 2013) utilises Sleeping Beauty lacZ transposons that have been randomly integrated into the mouse genome Hundreds of[…]

YEN Conference 2017: Registration open now!

Posted by on February 8th, 2017

Young Embryologist Network 9th Annual Conference. 9th May 2017 at the Institute of Child Health, UCL, London. This year, YEN is honoured to have Dr Darren Gilmour from EMBL Heidelberg present the Sammy Lee Memorial Lecture. We are also pleased to host two invited speakers, Dr Karen Liu (King’s College London), and Professor Michael Stumpf (Imperial College London). As well as three abstract-selected talk sessions and a poster[…]