the community site for and by developmental biologists

In vivo profiling of chromatin accessibility with CATaDa

Posted by on March 13th, 2018

The following post is an introduction into the technnique described in our recent paper: Aughey, G.N., et al., CATaDa reveals global remodelling of chromatin accessibility during stem cell differentiation in vivo. Elife, 2018. 7.   Attempting to understand the biology of a complex organ, like the brain, comes with an array of technical challenges. Those[…]

Manipulating the Mouse Embryo: Yesterday, today, and tomorrow… Symposium in honor of Professor Brigid Hogan

Posted by on March 13th, 2018

Last Friday March 9, a research symposium was held at Duke University in Durham, North Carolina to honor the career and retirement of Professor Brigid Hogan, Chair of the Department of Cell Biology (Hogan Lab Webpage: Current and former Hogan Lab members, colleagues, and friends came from across America, Japan, and the United Kingdom[…]

The people behind the papers – You Wu & Mineko Kengaku

Posted by on March 12th, 2018

Neuronal migration is critical for mammalian brain development. In many migrating neurons, the nucleus translocates from the trailing to the leading edge of the cell in a manner dependent on the actin and microtubule cytoskeletons, but how these cytoskeletons interact and their relative contribution to the forces that move the nucleus has remained unclear. This[…]

The Curious Case of Protocadherin 19 Epilepsy

Posted by on March 12th, 2018

Daniel Pederick & Paul Thomas Comment on our paper: Pederick, et al. 2018. Abnormal Cell Sorting Underlies the Unique X-Linked Inheritance of PCDH19 Epilepsy. Neuron 97 (1).   Here we discuss the curious case of female-restricted epilepsy, an unusual disorder caused by mutations in the Protocadherin 19 (PCDH19) gene. How changes in this cell adhesion[…]

Team work, good science

Posted by on March 8th, 2018

You can find our recently published eLife paper here.   At the Euro-Evo-Devo meeting in Lisbao I saw a talk by Sylvie Rétaux and became hooked by a blind and unpigmented cavefish: the evo-devo model Astyanax mexicanus. I then had the chance to join Sylvie’s group in Gif-sur-Yvette (France) in 2013, for a post-doc. Four[…]

Funded places for early-career researchers at a human brain development & evolution workshop

Posted by on March 8th, 2018

This summer, the Company of Biologists, the not-for-profit publisher of Development, is running a Workshop on ‘Development and evolution of the human neocortex‘, organised by Victor Borrell, Wieland Huttner and Arnold Kriegstein. The Company of Biologists Workshops provide leading experts and early career scientists from a diverse range of scientific backgrounds with a stimulating environment for the cross-fertilisation[…]

Stem cell fate choice: determined in an instant

Posted by on March 6th, 2018

Jun Chen National Institute of Biological Sciences, Beijing A discussion of our recent paper: Chen J, Xu N, Wang C, Huang P, Huang H, Jin Z, Yu Z, Cai T, Jiao R, Xi R. Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells. Nat Cell Biol. 2018[…]

Conformation of the insulin receptor

Posted by on March 5th, 2018

A few days back over dinner at a CNV gathering, Theresia Gutmann from the Coskun lab casually told me about her PhD work. In collaboration with the Rockefeller University NYC, Theresia had visualized the changing conformation of the human insulin receptor upon insulin binding (paper). I made a sketchnote summarizing their discovery of a conformational[…]

February in preprints

Posted by on March 1st, 2018

Our latest monthly trawl for developmental biology (and other cool) preprints. Let us know if we missed anything.   On February 20th, The Company of Biologists launched preLights, a community-led preprint highlighting service. A panel of early career researchers (the ‘preLighters’) select and comment on recent preprints that caught their eye, and encourage preprint authors[…]