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The Node is a place to share news about and with the developmental biology community around the world. If this is your first time on the site, check out this introduction to the Node. You can also find out more about us, and sign up to contribute.
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This month on the Node – January 2013
Posted by the Node on January 31st, 2013
Let’s start this monthly summary with two fantastic posts that were left out of last month’s roundup due to the holiday period (and scheduled posts). Idoia Quintana studies shark brain development in Spain, and travelled to Scotland recently to learn how to work with mouse brains, so she could do some cross-species comparison. “At the […]
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Post-doc position in evolution and development in Paris
Posted by MichelVervoort on January 31st, 2013
A two-year post-doctoral positionis available in the group of Guillaume Balavoine and Michel Vervoort (http://www.ijm.fr/en/ijm/research/research-groups/metazoaires/) at the Institut Jacques Monod (IJM) in Paris (France). The IJM is a leading French biological research institute, comprising about 25 interactive research groups and high-quality technological facilities, including a cutting-edge imaging platform. The primary research focus of the group is to […]
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Vote for a Development cover – Woods Hole 2012 class round 1
Posted by the Node on January 30th, 2013
Each year, students of the Woods Hole Embryology course produce some amazing images. Last year, readers of the Node selected four images from the 2011 course to appear on the cover of Development. Now it’s time to do the same with the images from the 2012 course. Here’s the first batch of […]
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In Development this week (Vol. 140, Issue 4)
Posted by Seema Grewal on January 29th, 2013
Here are the highlights from the current issue of Development: Pancreatic injury unlocks cell potential Identifying methods by which pancreatic β-cells can be produced is of major therapeutic importance. Whether there are adult pancreatic cells with the potential to make new β-cells is a matter of much debate. During embryonic development, the transcription factor […]
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Stem cells at school, plus new fact sheets on EuroStemCell
Posted by Emma Kemp on January 29th, 2013
Happy 2013 everyone! I hope you’re all settling into the year nicely.We sent out our EuroStemCell January newsletter last week and I thought some of you might be interested in our latest schools activities and fact sheets on stem cell research. Highlights this month include a new lesson for 12-14 year olds on Stem cell […]
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Woods Hole course application deadline extended
Posted by the Node on January 28th, 2013
The Woods Hole image voting posts are some of the most popular posts on the Node (and yes, there will be a new one up VERY soon!). These images are all made by students of the Woods Hole Embryology course, and you still have a chance to be part of the 2013 class! The application […]
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Microinjection of preimplantation mouse embryos
Posted by svanderweide on January 28th, 2013
Hello, my name is Stephanie and I’m a graduate student in Dr. Amy Ralston’s lab at the University of California Santa Cruz. I just returned from a trip to Dr. Yojiro Yamanaka’s lab at McGill University in Montreal, Quebec. This trip was funded by the Development Travelling Fellowship from Company of Biologists. I highly recommend checking […]
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PhD opportunity available in Dundee
Posted by Marios on January 17th, 2013
O-GlcNAc signalling during embryonic stem cell differentiation My lab is studying the signalling mechanisms governing the onset of differentiation of pluripotent embryonic stem (ES) cells. Work from this and other labs (e.g. 1, 2) has revealed a critical role for autocrine FGF signalling and consequent sustained phosphorylation of the kinase Erk during the differentiation process. […]
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PhD position in the UK for a Developmental Geneticist
Posted by Andre on January 16th, 2013
PhD project title: Non-genetic mechanisms of inheritance influenced by the maternal environment Project description: In the last few decades, it has been becoming increasingly clear that organisms can express phenotypes that are inherited in a non-Mendelian fashion. Studies in humans, for example, show that grandfathers who experienced dramatic diet fluctuations as children influenced the incidence […]
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Early mouse development seen in real time
Posted by Heather Ray on January 15th, 2013
Developmental biologists have long relied on the power of observation to understand how embryos develop. In addition, pharmacologic and genetic manipulation of embryos gives us clues as to the mechanisms involved in proper developmental processes. The ability to combine embryo manipulation with observation of embryonic development in real time has been possible for quite some […]
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- talpid2: a mystery finally solved [IN THIS ISSUE]
- Starvation MESses up the egg [IN THIS ISSUE]
- A taste for something new [IN THIS ISSUE]
- Cell heterogeneity and multilineage priming in the kidney [IN THIS ISSUE]
- The POU-er of gene nomenclature [SPOTLIGHT]
- The dynamics of plant plasma membrane proteins: PINs and beyond [REVIEW]
- Retinoic acid controls body axis extension by directly repressing Fgf8 transcription [RESEARCH REPORTS]
- The F-box protein Slmb restricts the activity of aPKC to polarize epithelial cells [RESEARCH REPORTS]
- Slmb antagonises the aPKC/Par-6 complex to control oocyte and epithelial polarity [RESEARCH ARTICLES]
- Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium [RESEARCH ARTICLES]
- The cellular and molecular etiology of the craniofacial defects in the avian ciliopathic mutant talpid2 [RESEARCH ARTICLES]
- Starvation induces FoxO-dependent mitotic-to-endocycle switch pausing during Drosophila oogenesis [RESEARCH ARTICLES]
- A crucial role for polysialic acid in developmental interneuron migration and the establishment of interneuron densities in the mouse prefrontal cortex [RESEARCH ARTICLES]
- The origin and loss of periodic patterning in the turtle shell [RESEARCH ARTICLES]
- Congenital heart disease protein 5 associates with CASZ1 to maintain myocardial tissue integrity [RESEARCH ARTICLES]
- Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis [RESEARCH ARTICLES]
- Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice [RESEARCH ARTICLES]
- Loss of focal adhesions in glia disrupts both glial and photoreceptor axon migration in the Drosophila visual system [RESEARCH ARTICLES]
- Islet is a key determinant of ascidian palp morphogenesis [RESEARCH ARTICLES]
- NF-kB controls axonal regeneration and degeneration through cell-specific balance of RelA and p50 in the adult CNS [Articles of interest in other COB journals]
- The conserved transmembrane proteoglycan Perdido/Kon-tiki is essential for myofibrillogenesis and sarcomeric structure in Drosophila [Articles of interest in other COB journals]
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- Editorial Board
- The basal position of nuclei is one pre-requisite for asymmetric cell divisions in the early mouse embryo
- The fat-like cadherin CDH-4 acts cell-non-autonomously in anterior–posterior neuroblast migration
- Staufen targets coracle mRNA to Drosophila neuromuscular junctions and regulates GluRIIA synaptic accumulation and bouton number
- Multiple tissue-specific requirements for the BMP antagonist Noggin in development of the mammalian craniofacial skeleton
- Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast
- Transcriptional regulation of Drosophila gonad formation
- Direct functional consequences of ZRS enhancer mutation combine with secondary long range SHH signalling effects to cause preaxial polydactyly
- Cdc42 is required in a genetically distinct subset of cardiac cells during Drosophila dorsal vessel closure
- Setdb2 controls convergence and extension movements during zebrafish gastrulation by transcriptional regulation of dvr1
- Functional characterization of Prickle2 and BBS7 identify overlapping phenotypes yet distinct mechanisms
- Daughterless homodimer synergizes with Eyeless to induce Atonal expression and retinal neuron differentiation
- SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans
- GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development
- Migratory neural crest cell αN-catenin impacts chick trigeminal ganglia formation
- Specific pattern of cell cycle during limb fetal myogenesis
- Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development
- Nemo promotes Notch-mediated lateral inhibition downstream of proneural factors
- Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression
- Gtpbp2 is required for BMP signaling and mesoderm patterning in Xenopus embryos
- Hectd1 is required for development of the junctional zone of the placenta
- Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation
- miR-203 regulates progenitor cell proliferation during adult zebrafish retina regeneration
- Dynamics of F-actin prefigure the structure of butterfly wing scales
- Germ cells of the centipede Strigamia maritima are specified early in embryonic development
- The expansion of body coloration involves coordinated evolution in cis and trans within the pigmentation regulatory network of Drosophila prostipennis
- Emergence of tissue sensitivity to Hox protein levels underlies the evolution of an adaptive morphological trait
- Long bone development requires a threshold of Hox function
- Enhancer diversity and the control of a simple pattern of Drosophila CNS midline cell expression
- A distant downstream enhancer directs essential expression of Tbx18 in urogenital tissues
- Editorial Board
- Development of the lateral line canal system through a bone remodeling process in zebrafish
- NEDD4L regulates convergent extension movements in Xenopus embryos via Disheveled-mediated non-canonical Wnt signaling
- Protein kinase CK2 both promotes robust proliferation and inhibits the proliferative fate in the C. elegans germ line
- TAF4b promotes mouse primordial follicle assembly and oocyte survival
- Regulation of broad by the Notch pathway affects timing of follicle cell development
- Cited2 is required in trophoblasts for correct placental capillary patterning
- Polyspermy block in jellyfish eggs: Collaborative controls by Ca2+ and MAPK
- The role of Bro1- domain-containing protein Myopic in endosomal trafficking of Wnt/Wingless
- Phosphorylation of CDK2 at threonine 160 regulates meiotic pachytene and diplotene progression in mice
- Transcriptional co-regulation of evolutionarily conserved microRNA/cone opsin gene pairs: Implications for photoreceptor subtype specification
- Corrigendum to “prdm12b Specifies the p1 progenitor domain and reveals a role for V1 interneurons in swim movements” [Dev. Biol. 390 (2014) 247–260]
- Abnormal cerebellar development and Purkinje cell Defects in Lgl1-Pax2 conditional knockout mice
- Specification of the mouse cardiac conduction system in the absence of Endothelin signaling
- Identification of genes driving lineage divergence from single-cell gene expression data in C. elegans
- The dystroglycan: Nestled in an adhesome during embryonic development
- Developmental regulation of glial cell phagocytic function during drosophila embryogenesis
- Editorial Board
- Resident progenitors, not exogenous migratory cells, generate the majority of visceral mesothelium in organogenesis
- A gene expression atlas of early craniofacial development
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- Wnt some lose some: transcriptional governance of stem cells by Wnt/{beta}-catenin signaling [Reviews]
- Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling [Reviews]
- Two waves of de novo methylation during mouse germ cell development [Research Communications]
- TRF2, but not TBP, mediates the transcription of ribosomal protein genes [Research Communications]
- Healing for destruction: tRNA intron degradation in yeast is a two-step cytoplasmic process catalyzed by tRNA ligase Rlg1 and 5'-to-3' exonuclease Xrn1 [Research Communications]
- The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages [Research Papers]
- Lineage of origin in rhabdomyosarcoma informs pharmacological response [Research Papers]
- Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions [Research Papers]
- A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication [Research Papers]
- MicL, a new {sigma}E-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein [Research Papers]
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- Spatial Regionalization and Heterochrony in the Formation of Adult Pallial Neural Stem Cells
- SAS-6 Assembly Templated by the Lumen of Cartwheel-less Centrioles Precedes Centriole Duplication
- High-Resolution Mapping of Chromatin Packaging in Mouse Embryonic Stem Cells and Sperm
- Uniformity of Nucleosome Preservation Pattern in Mammalian Sperm and Its Connection to Repetitive DNA Elements
- Regulation of Plant Stem Cell Quiescence by a Brassinosteroid Signaling Module
- Multiple Mechanisms Modulate Distinct Cellular Susceptibilities toward Apoptosis in the Developing Eye
- Independent Genomic Control of Neuronal Number across Retinal Cell Types
- Distinct Chemokine Signaling Regulates Integrin Ligand Specificity to Dictate Tissue-Specific Lymphocyte Homing
- Live Free or Die: Cell-Cell Adhesion Regulates Sensitivity to Trail-Induced Apoptosis
- The LC3 Acts Downstream of GABARAP to Degrade Autophagosomes by Interacting with the HOPS Subunit VPS39
- Finding a Common Path: Predicting Gene Function using Inferred Evolutionary Trees
- With NuRD, HDACs Go “Nerdy”
- Paternal Nucleosomes: Are They Retained in Developmental Promoters or Gene Deserts?
- Mitochondria Are Clamped to Vacuoles for Lipid Transport
- A Dynamic Interface between Vacuoles and Mitochondria in Yeast
- Cellular Metabolism Regulates Contact Sites between Vacuoles and Mitochondria
- Autophagosome Biogenesis in Primary Neurons Follows an Ordered and Spatially Regulated Pathway
