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The Node is a place to share news about and with the developmental biology community around the world. If this is your first time on the site, check out this introduction to the Node. You can also find out more about us, and sign up to contribute.
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This month on the Node – January 2013
Posted by the Node on January 31st, 2013
Let’s start this monthly summary with two fantastic posts that were left out of last month’s roundup due to the holiday period (and scheduled posts). Idoia Quintana studies shark brain development in Spain, and travelled to Scotland recently to learn how to work with mouse brains, so she could do some cross-species comparison. “At the […]
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Post-doc position in evolution and development in Paris
Posted by MichelVervoort on January 31st, 2013
A two-year post-doctoral positionis available in the group of Guillaume Balavoine and Michel Vervoort (http://www.ijm.fr/en/ijm/research/research-groups/metazoaires/) at the Institut Jacques Monod (IJM) in Paris (France). The IJM is a leading French biological research institute, comprising about 25 interactive research groups and high-quality technological facilities, including a cutting-edge imaging platform. The primary research focus of the group is to […]
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Vote for a Development cover – Woods Hole 2012 class round 1
Posted by the Node on January 30th, 2013
Each year, students of the Woods Hole Embryology course produce some amazing images. Last year, readers of the Node selected four images from the 2011 course to appear on the cover of Development. Now it’s time to do the same with the images from the 2012 course. Here’s the first batch of […]
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In Development this week (Vol. 140, Issue 4)
Posted by Seema Grewal on January 29th, 2013
Here are the highlights from the current issue of Development: Pancreatic injury unlocks cell potential Identifying methods by which pancreatic β-cells can be produced is of major therapeutic importance. Whether there are adult pancreatic cells with the potential to make new β-cells is a matter of much debate. During embryonic development, the transcription factor […]
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Stem cells at school, plus new fact sheets on EuroStemCell
Posted by Emma Kemp on January 29th, 2013
Happy 2013 everyone! I hope you’re all settling into the year nicely.We sent out our EuroStemCell January newsletter last week and I thought some of you might be interested in our latest schools activities and fact sheets on stem cell research. Highlights this month include a new lesson for 12-14 year olds on Stem cell […]
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Woods Hole course application deadline extended
Posted by the Node on January 28th, 2013
The Woods Hole image voting posts are some of the most popular posts on the Node (and yes, there will be a new one up VERY soon!). These images are all made by students of the Woods Hole Embryology course, and you still have a chance to be part of the 2013 class! The application […]
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Microinjection of preimplantation mouse embryos
Posted by svanderweide on January 28th, 2013
Hello, my name is Stephanie and I’m a graduate student in Dr. Amy Ralston’s lab at the University of California Santa Cruz. I just returned from a trip to Dr. Yojiro Yamanaka’s lab at McGill University in Montreal, Quebec. This trip was funded by the Development Travelling Fellowship from Company of Biologists. I highly recommend checking […]
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PhD opportunity available in Dundee
Posted by Marios on January 17th, 2013
O-GlcNAc signalling during embryonic stem cell differentiation My lab is studying the signalling mechanisms governing the onset of differentiation of pluripotent embryonic stem (ES) cells. Work from this and other labs (e.g. 1, 2) has revealed a critical role for autocrine FGF signalling and consequent sustained phosphorylation of the kinase Erk during the differentiation process. […]
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PhD position in the UK for a Developmental Geneticist
Posted by Andre on January 16th, 2013
PhD project title: Non-genetic mechanisms of inheritance influenced by the maternal environment Project description: In the last few decades, it has been becoming increasingly clear that organisms can express phenotypes that are inherited in a non-Mendelian fashion. Studies in humans, for example, show that grandfathers who experienced dramatic diet fluctuations as children influenced the incidence […]
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Early mouse development seen in real time
Posted by Heather Ray on January 15th, 2013
Developmental biologists have long relied on the power of observation to understand how embryos develop. In addition, pharmacologic and genetic manipulation of embryos gives us clues as to the mechanisms involved in proper developmental processes. The ability to combine embryo manipulation with observation of embryonic development in real time has been possible for quite some […]
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- Invadosomes: aiding axonal invasion [IN THIS ISSUE]
- Taking the strain out of stem cell renewal [IN THIS ISSUE]
- Reporting on {beta}-catenin in the vasculature [IN THIS ISSUE]
- PUB4 calls time on root cell division [IN THIS ISSUE]
- Reaching out - the many faces of science outreach [SPOTLIGHT]
- Mathematically guided approaches to distinguish models of periodic patterning [HYPOTHESIS]
- Building a plant: cell fate specification in the early Arabidopsis embryo [REVIEW]
- Regulation of ECM degradation and axon guidance by growth cone invadosomes [RESEARCH ARTICLES]
- {beta}-catenin-dependent transcription is central to Bmp-mediated formation of venous vessels [RESEARCH ARTICLES]
- DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos [RESEARCH ARTICLES]
- ERBB3-mediated regulation of Bergmann glia proliferation in cerebellar lamination [RESEARCH ARTICLES]
- A transient wave of BMP signaling in the retina is necessary for Muller glial differentiation [RESEARCH ARTICLES]
- Surrounding tissues canalize motile cardiopharyngeal progenitors towards collective polarity and directed migration [RESEARCH ARTICLES]
- Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea [RESEARCH ARTICLES]
- A dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face [RESEARCH ARTICLES]
- SMAD2 and p38 signaling pathways act in concert to determine XY primordial germ cell fate in mice [RESEARCH ARTICLES]
- Selective synaptic targeting of the excitatory and inhibitory presynaptic organizers FGF22 and FGF7 [Articles of interest in other COB journals]
- The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence by targeting Par4 [Articles of interest in other COB journals]
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- Editorial Board
- Differential pleiotropy and HOX functional organization
- A method for using direct injection of plasmid DNA to study cis-regulatory element activity in F0 Xenopus embryos and tadpoles
- Developmental alterations of the C. elegans male anal depressor morphology and function require sex-specific cell autonomous and cell non-autonomous interactions
- PLR-1, a putative E3 ubiquitin ligase, controls cell polarity and axonal extensions in C. elegans
- Mechanics of blastopore closure during amphibian gastrulation
- CSN maintains the germline cellular microenvironment and controls the level of stem cell genes via distinct CRLs in testes of Drosophila melanogaster
- Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT
- Nf2–Yap signaling controls the expansion of DRG progenitors and glia during DRG development
- Three-dimensional cultures of trophoblast stem cells autonomously develop vascular-like spaces lined by trophoblast giant cells
- Molecular characterization of the apical organ of the anthozoan Nematostella vectensis
- Fgf10 is required for specification of non-sensory regions of the cochlear epithelium
- Ecdysone response gene E78 controls ovarian germline stem cell niche formation and follicle survival in Drosophila
- Gene expression ontogeny of spermatogenesis in the marmoset uncovers primate characteristics during testicular development
- Pluripotent stem cell derived cardiovascular progenitors – a developmental perspective
- Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP dependent mechanisms
- RhoGAP68F controls transport of adhesion proteins in Rab4 endosomes to modulate epithelial morphogenesis of Drosophila leg discs
- The heparan sulfate-modifying enzyme glucuronyl C5-epimerase HSE-5 controls Caenorhabditis elegans Q neuroblast polarization during migration
- Loss of function of the yellow-e gene causes dehydration-induced mortality of adult Tribolium castaneum
- Co-expression of the transcription factors CEH-14 and TTX-1 regulates AFD neuron-specific genes gcy-8 and gcy-18 in C. elegans
- microRNAs regulate β-catenin of the Wnt signaling pathway in early sea urchin development
- Ontogeny of the mouse vocal fold epithelium
- Semi-solid tumor model in Xenopus laevis/gilli cloned tadpoles for intravital study of neovascularization, immune cells and melanophore infiltration
- The organizer in evolution–gastrulation and organizer gene expression highlight the importance of brachyury during development of the coral, Acropora millepora
- Editorial Board
- The BED finger domain protein MIG-39 halts migration of distal tip cells in Caenorhabditis elegans
- Pox neuro control of cell lineages that give rise to larval poly-innervated external sensory organs in Drosophila
- Pax8 and Pax2 are specifically required at different steps of Xenopus pronephros development
- Ptch2 shares overlapping functions with Ptch1 in Smo regulation and limb development
- The ABC transporter, AbcB3, mediates cAMP export in D. discoideum development
- Zebrafish Rab5 proteins and a role for Rab5ab in nodal signalling
- A function for the Joubert syndrome protein Arl13b in ciliary membrane extension and ciliary length regulation
- Sox21 regulates the progression of neuronal differentiation in a dose-dependent manner
- Stochasticity and stereotypy in the Ciona notochord
- Huntingtin interacting proteins 14 and 14-like are required for chorioallantoic fusion during early placental development
- Nucleolus-like bodies of fully-grown mouse oocytes contain key nucleolar proteins but are impoverished for rRNA
- Evolutionarily conserved role for SoxC genes in neural crest specification and neuronal differentiation
- A gene expression map of the larval Xenopus laevis head reveals developmental changes underlying the evolution of new skeletal elements
- Embryonic development of the nervous system in the planarian Schmidtea polychroa
- Pentimento: Neural Crest and the origin of mesectoderm
- The many faces of cell adhesion during Drosophila muscle development
- Lizard tail regeneration: regulation of two distinct cartilage regions by Indian hedgehog
- Loss of cftr function leads to pancreatic destruction in larval zebrafish
- Hanging on for the ride: Adhesion to the extracellular matrix mediates cellular responses in skeletal muscle morphogenesis and disease
- The boule gene is essential for spermatogenesis of haploid insect male
- The cochlear sensory epithelium derives from Wnt responsive cells in the dorsomedial otic cup
- Diverse ETS transcription factors mediate FGF signaling in the Ciona anterior neural plate
- Tie1 is required for lymphatic valve and collecting vessel development
- Insulin-independent role of adiponectin receptor signaling in Drosophila germline stem cell maintenance
- Wnt7b is required for epithelial progenitor growth and operates during epithelial-to-mesenchymal signaling in pancreatic development
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- From equator to pole: splitting chromosomes in mitosis and meiosis [Reviews]
- A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation [Research Communications]
- The transcription factor Nerfin-1 prevents reversion of neurons into neural stem cells [Research Papers]
- Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2 [Research Papers]
- Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth [Research Papers]
- ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis [Research Papers]
- FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation [Research Papers]
- Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination [Research Papers]
- Genome-wide chromatin footprinting reveals changes in replication origin architecture induced by pre-RC assembly [Research Papers]
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- A Role for the Ancient SNARE Syntaxin 17 in Regulating Mitochondrial Division
- Endocytosis of Hedgehog through Dispatched Regulates Long-Range Signaling
- Actin-Delimited Adhesion-Independent Clustering of E-Cadherin Forms the Nanoscale Building Blocks of Adherens Junctions
- Interkinetic Nuclear Migration Is Centrosome Independent and Ensures Apical Cell Division to Maintain Tissue Integrity
- Salvador-Warts-Hippo Pathway in a Developmental Checkpoint Monitoring Helix-Loop-Helix Proteins
- Phosphorylation of Cohesin Rec11/SA3 by Casein Kinase 1 Promotes Homologous Recombination by Assembling the Meiotic Chromosome Axis
