the community site for and by developmental biologists

About: DMDD

Biography:
DMDD is a systematic study of embryonic-lethal mouse gene knockouts. We provide a database of high-resolution images and phenotype data - a valuable resource for developmental biologists.
Website:
http://dmdd.org.uk

Posts by DMDD:

Workshop on HREM imaging and mouse phenotyping

Posted by on August 8th, 2017

Deciphering the Mechanisms of Developmental Disorders (DMDD) is a large-scale imaging and phenotyping  programme for genetically modified mouse embryos. For embryos at E14.5, the key imaging technique is High Resolution Episcopic Microscopy (HREM), and the resulting images are used to comprehensively phenotype the embryos using a systematic approach.     With a combination of lectures,[…]

9.5 million knockout mouse embryo images now available

Posted by on July 20th, 2017

A new set of DMDD embryo and placenta data has been released, taking our total dataset to 9.5 million images of around 1300 embryos. DMDD is a primary screen of embryonic lethal knockout mice, and all data can be freely accessed at dmdd.org.uk. Detailed phenotypes are available for embryos from 73 different knockout lines, and[…]

New complexities in relationship between gene mutation and embryo development

Posted by on April 11th, 2017

  A large-scale study of DMDD data has shown that inactivating the same gene in mouse embryos that are virtually genetically identical can result in a wide range and severity of physical abnormalities. This suggests that the relationship between gene mutation and embryo development is more complex than previously thought.     The study considered[…]

Why are geneticists measuring the webbing between mouse embryo fingers?

Posted by on February 21st, 2017

A new paper published in Journal of Anatomy shows that measuring the amount of inter-digital webbing in mouse embryos between 14 and 15 days gestation is the best way to find out their exact stage of development. So why is this important to a geneticist? If we want to discover a causal link between a gene[…]

New data reveals how gene knockouts affect whole embryo gene expression

Posted by on February 7th, 2017

New DMDD data released on Expression Atlas reveals the effect of single gene knockouts on the expression of all other genes in the mouse genome. The gene expression profiles of 11 knockout lines have been derived from whole embryos harvested at E9.5, and the results can be compared with wild-type controls using an interactive online[…]

New phenotype dataset available for embryonic-lethal mouse knockouts

Posted by on December 1st, 2016

    This post originally appeared on Annotations, the DMDD blog.   New image and phenotype data for embryos and placentas from embryonic lethal knockout mouse lines has been made available on the DMDD website today. The knockout data includes the ciliary gene Rpgrip1l as well as Atg16l1, a gene encoding a protein that forms[…]

New phenotype screen examines causes of neonatal death

Posted by on October 4th, 2016

This post first appeared on Annotations, the DMDD blog (blog.dmdd.org.uk). Around a third of targeted gene knockouts in mice are embryonic-lethal. But not all deaths occur during gestation – a significant number of gene knockouts result in death at or shortly after the time of birth. Mice from these knockout lines provide a valuable animal[…]

New data reveals gene expression during mouse embryo development

Posted by on September 29th, 2016

This article was originally posted on the DMDD website dmdd.org.uk Knowing the ‘normal’ expression of genes during embryo development is key to understanding the differences that occur due to genetic mutations. As part of work to understand the underlying transcriptional processes for developing embryos from knockout mouse lines, DMDD has now released a gene expression[…]

New DMDD embryonic-lethal mouse data now available

Posted by on August 15th, 2016

  This post was originally posted on the DMDD blog.   New embryonic-lethal knockout mouse lines are now available on the DMDD database. If you haven’t previously taken a look at our data (or even if you have) now would be a good time to explore our website.  We’ve added new embryo phenotype data and[…]

The Zika Virus and Systematic Screens of Mouse Mutations

Posted by on July 14th, 2016

  This post was originally published on the DMDD blog.     The Zika virus has raised global awareness of birth defects more than at any time in the last 50 years [1]. A recent Nature Editorial explores the opportunities this presents to increase support for vaccination programmes, compulsory fortification of food staples and investment[…]