![Figure 1 Schematic of the clock model as proposed by Thorogood (1991). (A) The bold arrow represents the timing of the AER-to-AF transition in the developmental process. (B-D) Hypothesized representations of fin/limb development in the clock model (above) with endochondral skeletal patterns of the fin/limb (below,). (B) Fin development in a teleost, demonstrating a short period of time with AER signaling prior to the AER-to-AF transition. (C) Fin development in lobe-finned fishes, showing a longer relative time with AER signaling prior to AF transformation. (D) Limb development in a tetrapod, in which AER signaling persists throughout limb development. Figure modified from Yano et al. [3]; based on Thorogood [2]; with fossil form representations in C-D from Long et al. [4].](http://thenode.biologists.com/wp-content/uploads/2013/04/node1-70x45.png){kind=small}
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Biography:
- I'm a developmental biologist who grew up in the United States, moved to France during my Ph.D. and have stayed here ever since. I've been working in human genetics divisions since 2002 and am currently studying the implication of neural crest cells in cardiac malformations in Marseille. I play the clarinet, I sing alto on occasion and I'm bilingual, of course.
Website:
- http://www.zaffranlab.com/
Posts by Heather:
- Conference announcement: Advances in stem cell research: Development, Regeneration & Disease in Paris, France
- Nothing beats a movie for developmental biologists
- A primer or two in collegiality and mutual benefit
- Meeting report from the 2nd joint meeting of the SFBD AND JSDB 2010 - "From Cells to Organs"
- Write your next article with your head in a cloud
