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About: Seema Grewal

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Reviews Editor at Development
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Posts by Seema Grewal:

In Development this week (Vol. 144, Issue 6) – SPECIAL ISSUE ON ORGANOIDS

Posted by on March 14th, 2017

The current issue of Development – our Special Issue on Organoids – features a collection of review- and research-based articles focusing on organoids. Here are some of the highlights. Happy reading (and thanks to everyone who contributed)!   Organoids: a Special Issue In her Editorial, Melissa Little provides an overview of the entire contents of the[…]

In Development this week (Vol. 144, Issue 5)

Posted by on February 28th, 2017

Here are the highlights from the new issue of Development:   Adding a new layer of complexity to pre-eclampsia Pre-eclampsia (PE) is a pregnancy complication associated with abnormal formation of the placenta. To date, most studies of PE have focussed on cytotrophoblasts (CTBs) within the villous placenta (the chorion frondosum); the deficient invasion of these[…]

In Development this week (Vol. 144, Issue 4)

Posted by on February 14th, 2017

Here are the highlights from the new issue of Development:   A new mechanism in ESC lineage priming Histone demethylases have recognized roles in the control of gene expression during development and disease, and are typically associated with the remodelling of the chromatin environment. Jmjd2/Kdm4 H3K9-demethylases cooperate in promoting mouse embryonic stem cell (ESC) identity,[…]

In Development this week (Vol. 144, Issue 3)

Posted by on January 31st, 2017

Here are the highlights from the current issue of Development:   Evolving an atypical developmental programme with IMM The brown alga Ectocarpus has alternating haploid (gametophyte) and diploid (sporophyte) generations. Morphologically, these are distinguished by a more complex system of basal filaments in the sporophyte, initiated via symmetric divisions before the apical-basal axis is defined[…]

In Development this week (Vol. 144, Issue 2)

Posted by on January 17th, 2017

Here are the highlights from the current issue of Development:   ECM: bridging the gap between germ layers The extracellular matrix (ECM) plays crucial roles during morphogenesis but how it is assembled and patterned in vivo is poorly understood. Here, Yuki Sato, Rusty Lansford and colleagues investigate this by examining the distribution of the ECM[…]

In Development this week (Vol. 144, Issue 1)

Posted by on January 3rd, 2017

Here are the highlights from the new issue of Development – the first one of the year. Happy reading…and Happy New Year!   Embryos rewired: the changing metabolome of early embryogenesis During early mammalian embryogenesis, the developing embryo must adapt to changing metabolic demands and substrate availability. It has long been thought that a metabolic[…]

In Development this week (Vol. 143, Issue 24)

Posted by on December 13th, 2016

Here are the highlights from the new issue of Development…the last one of the year!   SETting chromatin state through transcription Setd5 is a poorly characterised murine member of the SET domain family, generally associated with histone methyltransferase activity. However, the closest homologues of Setd5 are thought to be catalytically inactive, and have instead been[…]

In Development this week (Vol. 143, Issue 23)

Posted by on November 29th, 2016

Here are the highlights from the current issue of Development:   Syndecan 4 lets lymphatic endothelial cells go with the flow Fluid flow is known to play a role in the development and remodelling of both blood and lymphatic vessels. But how is fluid flow sensed and transduced into a response? Here, Michael Simons and[…]

In Development this week (Vol. 143, Issue 21)

Posted by on November 1st, 2016

Here are the highlights from the current issue of Development:   Signalling cross-talk in the plant root In plants, root architecture is responsive to environmental changes. The plant hormones cytokinin, auxin and ethylene are known to regulate root growth: cytokinin signalling, acting via type-B ARR effectors, inhibits both proliferation and elongation of root cells, while[…]

In Development this week (Vol. 143, Issue 20)

Posted by on October 18th, 2016

Here are the highlights from the new issue of Development:   Glucocorticoid and STAT3: tipping the balance in the lung The epithelial cells found at the distal tips of the developing lung comprise a multipotent progenitor population. During development, these cells first give rise to bronchiolar cells, which form the conducting airways, but then switch[…]