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About: Seema Grewal

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Reviews Editor at Development
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In Development this week (Vol. 138, Issue 4)

Posted by on January 26th, 2011

Here are the research highlights from the current issue of Development: New moves in haematopoiesis: rumba and samba Vertebrate haematopoiesis relies on a pool of haemetopoietic stem/progenitor cells (HSPCs) that can self-renew and differentiate into all haematopoietic lineages. But what are the molecular mechanisms that regulate this process? Here, Zilong Wen and co-workers (p. 619)[…]

In Development this week (Vol. 138, Issue 3)

Posted by on January 4th, 2011

Here are the research highlights from the new issue of Development: Wnt/PCP signalling, microtubules and gastrulation During vertebrate gastrulation, convergence and extension (C&E) movements shape the germ layers to form the anterioposteriorly elongated body axis of vertebrate embryos. Non-canonical Wnt/planar cell polarity (Wnt/PCP) signalling regulates C&E by polarising the morphology and behaviour of cells, which[…]

In Development this week (Vol. 138, Issue 2)

Posted by on December 21st, 2010

Boning up on stem cell Igf2-P2 function The insulin-like growth factor (IGF)/insulin signalling pathway regulates cell proliferation, differentiation, aging and life span. During embryonic development, transcription of the mouse and human Igf2 gene is tightly regulated by four alternative promoters whose specific roles are unclear. Now, Sylvie Nathalie Hardouin and colleagues reveal that the transcriptional[…]

In Development this week (Vol. 138, Issue 1)

Posted by on December 7th, 2010

The first issue of 2011 is out now…here are the highlights: Geminin control of lineage commitment The transition between pluripotency and multi-lineage commitment during early embryogenesis must be closely regulated to ensure correct spatial and temporal patterning of the embryo. But what regulates this crucial transition? According to Kristen Kroll and co-workers, part of the[…]

In Development this week (Vol. 137, Issue 24)

Posted by on November 23rd, 2010

Pak1-ing a punch in lumen formation The generation and maintenance of correct lumen size and shape is essential for the function of tubular organs. Now, Monn Monn Myat and co-workers report that p21-activated kinase (Pak1) plays a novel role during lumen formation in Drosophila embryonic salivary glands (see p. 4177). The researchers show that Pak1[…]

In Development this week (Vol. 137, Issue 23)

Posted by on November 9th, 2010

The current issue of Development is now online! Here are the research highlights: Klf5: a multifaceted regulator of cell fate Kruppel-like transcription factors (Klfs) induce and maintain pluripotency in embryonic stem cells (ESCs), and Klf4 is one of the factors used to create reprogrammed iPS cells. The role of Klfs in the specification of the[…]

In Development this week (Vol. 137, Issue 22)

Posted by on October 26th, 2010

Research highlights from the current issue of Development: Novel Hh targets fly in Hedgehog (Hh), a secreted morphogen, acts in a paracrine fashion to regulate tissue patterning during embryogenesis. Its tissue-specific effects are mediated by the transcription factor Cubitus interruptus (Ci), but how it exerts such effects is unclear. On p. 3887, Thomas Kornberg and[…]

In Development this week (Vol. 137, Issue 21)

Posted by on October 12th, 2010

Here are the research highlights from the current issue of Development: Oct1: essential for trophoblast development Most POU family transcription factors are temporally and spatially restricted during development and play pivotal roles in specific cell fate determination events. Oct1 (Pou2f1), however, is ubiquitously expressed in embryonic and adult mouse tissues; so, does Oct1 have a[…]

In Development this week (Vol 137, Issue 20)

Posted by on September 28th, 2010

A fateful look at early mouse lineage specification The first cell lineages specified in the mouse embryo are the trophectoderm (TE), which generates the embryonic portion of the placenta, and the inner cell mass (ICM). The ICM subsequently forms the pluripotent epiblast (EPI, which produces the embryo) and the primitive endoderm (PrE, which generates other[…]

In Development this week (Vol 137, Issue 19)

Posted by on September 7th, 2010

Here are the research highlights from the current issue of Development: Nr5a receptors reset EpiSC pluripotency Rodent embryonic stem (ES) cells that are derived from blastocysts self-renew without mitogenic growth factors and robustly colonize chimaeras, whereas egg cylinder-derived stem cells (EpiSCs) require fibroblast growth factor and contribute poorly to chimaeras. Nevertheless, expression of a single[…]