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About: Seema Grewal

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Reviews Editor at Development
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Posts by Seema Grewal:

In Development this week (Vol. 143, Issue 24)

Posted by on December 13th, 2016

Here are the highlights from the new issue of Development…the last one of the year!   SETting chromatin state through transcription Setd5 is a poorly characterised murine member of the SET domain family, generally associated with histone methyltransferase activity. However, the closest homologues of Setd5 are thought to be catalytically inactive, and have instead been[…]

In Development this week (Vol. 143, Issue 23)

Posted by on November 29th, 2016

Here are the highlights from the current issue of Development:   Syndecan 4 lets lymphatic endothelial cells go with the flow Fluid flow is known to play a role in the development and remodelling of both blood and lymphatic vessels. But how is fluid flow sensed and transduced into a response? Here, Michael Simons and[…]

In Development this week (Vol. 143, Issue 21)

Posted by on November 1st, 2016

Here are the highlights from the current issue of Development:   Signalling cross-talk in the plant root In plants, root architecture is responsive to environmental changes. The plant hormones cytokinin, auxin and ethylene are known to regulate root growth: cytokinin signalling, acting via type-B ARR effectors, inhibits both proliferation and elongation of root cells, while[…]

In Development this week (Vol. 143, Issue 20)

Posted by on October 18th, 2016

Here are the highlights from the new issue of Development:   Glucocorticoid and STAT3: tipping the balance in the lung The epithelial cells found at the distal tips of the developing lung comprise a multipotent progenitor population. During development, these cells first give rise to bronchiolar cells, which form the conducting airways, but then switch[…]

In Development this week (Vol. 143, Issue 19)

Posted by on October 4th, 2016

Here are the highlights from the current issue of Development:   Defining digit number in the limb During vertebrate limb development, multiple mechanisms act to ensure the appropriate number, identity and positioning of digits. In both the chick and the mouse, Sonic hedgehog (Shh) signalling emanating from the posterior polarising region provides positional information and[…]

In Development this week – Special Issue on Plant Development

Posted by on September 13th, 2016

The current issue of Development – our ‘Special Issue on Plant Development’ – contains a collection of review- and research-based articles focusing on plant development.   Below, you can find details of the review-based articles in this Special Issue:   Plant development: a Special Issue Ottoline Leyser introduces this Special Issue focusing on plant developmental biology,[…]

In Development this week (Vol. 143, Issue 17)

Posted by on August 30th, 2016

Here are the highlights from the current issue of Development:   Coordinating neuronal specification and differentiation Neurogenesis – the process of making new neurons – is indispensable for normal development and for adult homeostasis and repair. Many of the signalling and transcriptional events that regulate the specification and differentiation of neural progenitor cells (NPCs) into[…]

In Development this week (Vol. 143, Issue 15)

Posted by on August 2nd, 2016

Here are the highlights from the current issue of Development:   Defining Polycomb complexes with AEBP2 Polycomb repressive complex 2 (PRC2) directs methylation of histone H3 K27 (H3K27me), a repressive histone mark. Mutations in PRC2 complex components cause a spectrum of developmental defects, including posterior transformation of the skeleton due to misexpression of Hox cluster[…]

In Development this week (Vol. 143, Issue 14)

Posted by on July 19th, 2016

Here are the highlights from the current issue of Development:   Gestational stress: at the heart of birth defects Congenital heart disease (CHD) is the most common form of human birth defect, yet the genetic and environmental factors that contribute to CHD remain poorly understood. Here, Sally Dunwoodie and colleagues investigate how gestational hypoxia affects[…]

In Development this week (Vol. 143, Issue 13)

Posted by on July 5th, 2016

Here are the highlights from the current issue of Development:   A pioneer role for PBX1 in neurogenesis The adult rodent subventricular zone (SVZ) is a neurogenic niche that provides new neurons and glia to the brain. A number of transcription factors, including MEIS2 and PAX6, are known to be required to promote the neuronal[…]