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The people behind the papers – Ximena Anleu Gil & Dominique Bergmann

Posted by on July 18th, 2018

Asymmetric division is a widespread mechanism for generating cellular diversity during developmental patterning. The stomata of flowering plants are epidermal valves that regulate gas exchange, and provide an accessible system to investigate the mechanisms of asymmetric cell division both within and across species. A paper in the new issue of Development reports an investigation of the molecular control of this[…]

The people behind the papers – Martina Nagel & Rudolf Winklbauer

Posted by on July 6th, 2018

Contact inhibition of locomotion is a widespread phenomenon in migrating cells. However, cells often migrate collectively as a sheet, raising the question of how contact inhibition is overcome in these scenarios. A new paper in Development addresses this problem by studying the signals that regulate collective migration in Xenopus leading edge mesendoderm (LEM) cells. We[…]

The people behind the papers – Kana Ishimatsu, Tom Hiscock & Sean Megason

Posted by on June 12th, 2018

Somites are segmented structures  which give rise to numerous tissues in the vertebrate body. It has long been observed that somites scale in size with the overall size of the embryo, both as development proceeds and between individuals of different sizes, but the molecular underpinnings of this process have remained controversial. A new paper in[…]

The people behind the papers – Pauline Anne & Christian Hardtke

Posted by on May 25th, 2018

Short CLE peptides regulate a wide variety of processes during plant development. In the developing root, the receptors and co-receptors for CLEs have remained largely unclear, as have the relationships between different CLEs and different (co-)receptors. A new paper in Development addresses this problem by reporting a new receptor kinase involved in CLE signaling. We caught[…]

The people behind the papers – Cathy Pichol-Thievend, Natasha Harvey & Mathias Francois

Posted by on May 22nd, 2018

The vertebrate lymphatic vascular network provides crucial circulatory and immune functions but its developmental origin has been a contentious issue, in particular the question of whether lymphatic endothelial cells have an exclusively venous origin. A new paper in Development addresses this issue in the dermis of the mouse embryo. To find out more about the[…]

The people behind the papers – Samira Benhamouche-Trouillet, Evan O’Loughlin & Andrea McClatchey

Posted by on May 21st, 2018

Intrahepatic bile ducts (IHBDs) are epithelial tubular structures that transport bile from the liver to the intestine, but the molecules and mechanisms controlling IHBD morphogenesis have remained largely unclear. A a recent paper in Development reports an investigation into IHBD development and the role the tumour suppressor and cytoskeletal regulator Merlin plays in the process. We caught[…]

The people behind the papers – Sa Geng & James Umen

Posted by on April 19th, 2018

The transition to multicellularity in eukaryotes appears to be intimately linked to the transition from isogamy (gametes of the same size) to anisogamy (gametes of distinct sizes), and indeed to oogamy, a form of anisogamy with a large, immotile egg and a motile sperm. Volvocine algae provide a useful and fascinating model to study how[…]

The people behind the papers – Jinjin Zhu & Justin Kumar

Posted by on April 9th, 2018

Cell fate commitment relies on both activation of appropriate genes and suppression of inappropriate ones. Polycomb group proteins are known to be crucial epigenetic silencers of developmental genes, but the manner by which they control fate in vivo, and the relative roles of different Polycomb proteins in silencing, have remained unclear. A new paper in Development[…]

The people behind the papers – Rémi-Xavier Coux & Ruth Lehmann

Posted by on April 5th, 2018

Development and homeostasis depend crucially on the maintenance of cell identity, and in gamete-producing tissues the somatic/germline distinction is paramount. A recent paper in Development explores how cell identity is secured in the Drosophila ovary by studying the function of the conserved tumour suppressor L(3)mbt. To find out more about the story, we caught up with first author Rémi-Xavier[…]

The people behind the papers – You Wu & Mineko Kengaku

Posted by on March 12th, 2018

Neuronal migration is critical for mammalian brain development. In many migrating neurons, the nucleus translocates from the trailing to the leading edge of the cell in a manner dependent on the actin and microtubule cytoskeletons, but how these cytoskeletons interact and their relative contribution to the forces that move the nucleus has remained unclear. This[…]