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New data reveals gene expression during mouse embryo development

Posted by on September 29th, 2016

This article was originally posted on the DMDD website Knowing the ‘normal’ expression of genes during embryo development is key to understanding the differences that occur due to genetic mutations. As part of work to understand the underlying transcriptional processes for developing embryos from knockout mouse lines, DMDD has now released a gene expression[…]

Exciting news on neural stem cell niches: stunning research from Fiona Doetsch’s lab

Posted by on August 26th, 2016 Sense & Sensibility: niche signals regulate neural stem cells in an age-dependent manner paper feature by Thomas Schwarz-Romond Tissue specific stem cell niches provide lifelong support for adult stem cells. The cell-biological dissection of (adult neural) stem cell – niche interactions uncovered unexpected regulatory functions. These new results imply that stem cell niches actively[…]

FaceBase: An online resource for craniofacial research

Posted by on August 16th, 2016

In 2009, FaceBase was launched in response to the need for more comprehensive analysis of craniofacial development: with so much craniofacial data being generated, there is a danger of relevant datasets being buried in the avalanche of genomic and other data. FaceBase is a curated, one-stop shop for facial development and research offering the community input and[…]

New DMDD embryonic-lethal mouse data now available

Posted by on August 15th, 2016

  This post was originally posted on the DMDD blog.   New embryonic-lethal knockout mouse lines are now available on the DMDD database. If you haven’t previously taken a look at our data (or even if you have) now would be a good time to explore our website.  We’ve added new embryo phenotype data and[…]

July in preprints

Posted by on August 1st, 2016

Our latest monthly trawl for preprints. See June’s post for background, and let us know if we missed anything This month we found preprints on various themes in developmental biology, as well as a lot of work that we hope will be of general interest to the community. One of July’s most talked-about preprints tackled a subject felt keenly by most scientists,[…]

June in preprints

Posted by on July 6th, 2016

In this new feature, we conduct a trawl for preprints to find the latest developmental biology and related research from the previous month. Scientists are increasingly using preprints as a way of releasing research to the community without having to wait for the peer review process, and we want to promote this content here. Several sites host[…]

Model Organism Database funding is in trouble: Let your voice be heard

Posted by on June 23rd, 2016

  Model Organisms such as yeast, worm, fly, fish, rat, and mouse are key drivers of biological research, providing manipulable and cost-effective experimental systems that continuously yield fundamental insights into human biology and health. These discoveries rely on the accumulated wealth of genetic, genomic and cellular knowledge for each organism, which is made accessible via[…]

Sweetening with a pinch of salt: maximized Cas9 efficiency in zebrafish

Posted by on June 14th, 2016

  Alexa Burger, Mosimann lab, Institute of Molecular Life Sciences, University of Zürich, Switzerland. When I first heard about the “new” genome editing method in early 2013 called CRISPR-Cas9, I thought: “Never ever again will I work with targeted nucleases!” Now it’s mid-2016, we published our approaches to maximize Cas9 effectiveness in zebrafish with Development[…]

Improving the design of animal experiments: Introducing the Experimental Design Assistant (EDA)

Posted by on June 7th, 2016

This post was originally published as a Newsletter article from ShARM (Shared Ageing Research Models) Scientists using animals in research have a responsibility to ensure that the studies are appropriately designed, conducted, analysed and reported so that they impartially and robustly answer the question they are intended to, and truly add to the knowledge base. Unfortunately there[…]

Geometrical models of tissue as tools for uncovering rules underlying tissue organization

Posted by on May 27th, 2016

A major challenge in cell and developmental biology is to understand the mechanisms whereby cells interact with each other to form the variety of complex tissue forms present in organisms. This requires visualizing and analysing different cellular processes across multiple scale levels -from the subcellular to the tissue, i.e. generating cell and tissue models at[…]