the community site for and by developmental biologists

Transparent mouse embryos and hematopoietic cell clusters

Posted by on November 8th, 2010

I was lucky in graduate school and my postdoctoral research—I was a microscopist working on a transparent organism (C. elegans).  Some microscopists don’t have that luxury, but have developed amazing techniques in order to visualize development in organisms such as mice.  In the November 1 issue of Development, Yokomizo and Dzierzak use a technique that[…]

the Node update – writers, thumbs, polls, and emails

Posted by on November 8th, 2010

Writing for the Node Have any of the entries on the Node inspired you to add something yourself? Go ahead! We’d like to remind you that you don’t need to ask permission to write for the Node. You also don’t need to wait for us to ask you to write something – although we might.[…]

SfN meeting: a 21st century event

Posted by on November 3rd, 2010

The annual meeting of the Society for Neuroscience kicks off in San Diego at the end of next week, and there are a lot of interesting updates even for people who, like me, are sadly *not* attending. First of all, if you’re planning to go but haven’t yet registered, you can register on site, but[…]

A primer or two in collegiality and mutual benefit

Posted by on November 2nd, 2010

Who wants to reinvent the wheel? Resources for finding or judging the worth of PCR primers, particularly for quantitation or amplification of cDNA.

An interview with Shinichi Aizawa: President of the Japanese Society of Developmental Biologists

Posted by on October 29th, 2010

(This interview previously appeared in Development) This August, the Society for Developmental Biology (SDB) held their annual meeting in Albuquerque, New Mexico, USA, jointly with the Japanese Society of Developmental Biologists (JSDB). The JSDB has recently increased their international profile under the presidency of Dr Shinichi Aizawa from the RIKEN Center for Developmental Biology (CDB).[…]

WormBase: It’s not just for C. elegans anymore

Posted by on October 29th, 2010

WormBase — — is the central data repository for Caenorhabditis elegans and related nematodes. C. elegans is a well-known system for studying problems in developmental biology, the benefits of which I will quickly rehash here. Its rapid generation time from fertilized egg to gravid adult (3.5 days) and small size (1mM) permit 1000’s of[…]

Making life out of noise: “Stochasticity in cell and developmental processes”. Cumberland Lodge, Windsor, UK, 17-20 October, 2010. Organized by The Company of Biologists.

Posted by on October 28th, 2010

I always travel with my suitcase packed with genes. Airports, planes and trains offer me the only instances where I find two hours solid of work, and they (genes) are then my best companions. However, in my discipline – developmental biology – it seems lately that, by simply analysing more genes, we are not getting[…]

Grant writing in Africa

Posted by on October 27th, 2010

Today I gave a grant writing seminar for about 25 participants and went through the general structure and preparation as well as the expectations of reviewers and granting agencies.  The whole presentation went really well, and I clearly had an interested audience actively taking notes and asking really insightful questions.  A good conversation followed about[…]


Posted by on October 26th, 2010

ReplicationDomain is an online database resource for storing, sharing and visualizing DNA replication timing and transcription data, as well as other numerical epigenetic data types. Data is typically obtained from DNA microarrays or DNA sequencing. Our site has a user registration system that allows registered users to upload their own data sets. While non-registered users[…]

In Development this week (Vol. 137, Issue 22)

Posted by on October 26th, 2010

Research highlights from the current issue of Development: Novel Hh targets fly in Hedgehog (Hh), a secreted morphogen, acts in a paracrine fashion to regulate tissue patterning during embryogenesis. Its tissue-specific effects are mediated by the transcription factor Cubitus interruptus (Ci), but how it exerts such effects is unclear. On p. 3887, Thomas Kornberg and[…]