PhD position in Nephrology in Freiburg, Germany

Studying mechanisms of genetic renal disease in Drosophila and mouse

The Renal Division of the University Medical Center Freiburg is offering a PhD position (DFG-funded). The position is available for three years and should be filled as soon as possible (starting in fall 2018).

Project:

• The lab is interested in studying mechanisms of genetic renal disease with a focus on monogenic causes of nephrotic syndrome.
• To this end we are utilizing the Drosophila and mouse animal models in conjunction with approaches in vitro.
• The podocyte-like Drosophila nephrocytes will be employed to characterize disease genes functionally and for whole-animal drug screening to develop novel therapeutic strategies.
• The candidate will work in diverse scientific environment with intensive supervision and support.

Requirements:

• We are looking for a highly motivated and ambitious candidate with a strong interest in basic research with clinical relevance.
• The applicant should hold a master’s degree in Biology, Molecular Medicine or an equivalent discipline.
• Experience in cell biology, mice and/or Drosophila is desirable but not mandatory.

Application: Interested candidates should send an application including a CV, a brief motivation letter and two references to

Dr. Tobias Hermle (tobias.hermle[at]uniklinik-freiburg[dot]de).

Selected References:

1. Hermle, T, Schneider, R, Schapiro, D, Braun, DA, van der Ven, AT, Warejko, JK, et al.: GAPVD1 and ANKFY1 Mutations Implicate RAB5 Regulation in Nephrotic Syndrome. J Am Soc Nephrol, 2018.

2. Helmstadter, M, Huber, TB, Hermle, T: Using the Drosophila Nephrocyte to Model Podocyte Function and Disease. Front Pediatr, 5: 262, 2017.

3. Hermle, T, Braun, DA, Helmstadter, M, Huber, TB, Hildebrandt, F: Modeling Monogenic Human Nephrotic Syndrome in the Drosophila Garland Cell Nephrocyte. J Am Soc Nephrol,28: 1521-1533, 2017.

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