Postdoc and PhD positions – Stem Cell Modeling of Development and Disease, Berlin

Postdoc and PhD positions are currently available in the Gouti Lab at Max Delbrück Centre for Molecular Medicine in the Helmholtz Association (MDC), Berlin.

The Gouti lab uses human and mouse pluripotent stem cells to model embryo development in vitro and unravel the mechanisms that regulate cell fate decisions during neuromuscular system development. During embryonic development spinal cord motor neurons are generated with high precision along the anterior-posterior (AP) axis and establish connections with skeletal muscles to control movement. We seek to understand how these two tissues are generated and interact in space and time during neuromuscular system development. 

We have recently succeeded in generating neuromesodermal progenitors (NMP) cells in vitro from mouse and human pluripotent stem cells that can be further differentiated to spinal cord neurons and/or muscle cells. The in vitro generation of NMP cells opens up new opportunities for the study and treatment of neuromuscular diseases as it gives unprecedented access to the simultaneous development of both neural and mesodermal cell types in the “dish” (Gouti et al, Plos Biology 2014; Gouti et al, Trends Genet, 2015;).

We are looking for  highly motivated, talented Postdoctoral fellows and Ph.D students to contribute to the research area of neuromuscular system development and disease. 
Our lab uses, stem cell modeling in parallel with genetic engineering techniques (Crispr/Cas9), next generation sequencing (single cell RNA-seq, ChiP-seq) and live cell imaging.

The MDC provides a state of the art human iPS cell core facility and the opportunity to work in an interdisciplinary environment of research excellence.

The Gouti Lab is actively involved in iMed, which includes five other Helmholtz centers in the Research Field Health besides the MDC. The program aims to interlink and coordinate the research activities of the centers in the field of personalized medicine and, through collaboration with local clinical partners, to promote the rapid transfer of research results into clinical practice.

For the Ph.D. positions interested applicants are encouraged to apply through the MDC Ph.D. program. The deadline for the current open Ph.D. call is 1st of July.  For more information please visit : Ph.D at MDC

For the Postdoc positions, interested applicants should have previous experience in stem cell biology, muscle biology, developmental biology, live cell imaging and/ or analysis of high-throughput  data. Strong publication record and ability to communicate research findings in English are essential.

To apply for a postdoc position, please send a letter of scientific interest along with your CV, publication list and contact information of 2 -3 referees to Mina Gouti (mina.gouti@mdc-berlin.de.). Closing date : 31st of August

For more information please visit: Gouti Lab, Diseases of the Nervous System, MDC

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