postdoctoral fellow position: Hedgehog control of neuronal activity.

We invite applications for a postdoctoral position to join a multidisciplinary project in the Alenius group at Umeå university. The project is based on our recent discovery that Hedgehog control neuronal activity in both Drosophila and mouse^{1. 2}  The approach is to combine Drosophila genetics, biochemistry with imaging in order to investigate the fundamental mechanisms that control neuronal activity and communication.

We are now looking for a highly motivated candidate, with a strong background in either Drosophila molecular biology or cell signalling. Additional skills in Drosophila neuroscience, imaging, and cryo-EM are considered a plus. The position involves using Drosophila genomic tools, biochemistry and live cell imaging, which in combination with cryo-EM and super-resolution microscopy and cutting-edge neuroscience approaches to identify the mechanisms by which hedgehog regulate neuronal activity.

Candidates are encouraged to send applications (cover letter, CV, and contact information of 3 references) to mattias.alenius@umu.se. Recommended application deadline is May 15th, 2018. Application review will start immediately until the position is filled. Openings are available immediately and the position is funded until the end of 2020.

Umeå and the Department of molecular biology: Umeå is a very metropolitan city with an international, welcoming and open attitude. The university and the department of molecular biology has a long standing tradition of big discoveries and is the birth place of the CRISPR/Cas9 technology. The university has several highly advanced technical platforms, including imaging and correlative electron microscopy platforms. The Department is creative, interdisciplinary and cutting edge and you will be part of one of the strongest Drosophila research environments in Sweden.

1. 1. Hedgehog signaling regulates ciliary localization of mouse odorant receptors. PNAS, Kumar Maruya D., Bohm S. and Alenius M. 2017
2. Hedgehog signaling regulates the ciliary transport of odorant receptors in Drosophila. Cell Reports, Sanchez G. M., Alkhori L., Hatano E., Schultz S. W., Kuzhandaivel A., Jafari S., Granseth B., and Alenius M. 2016

Group page: (http://www.molbiol.umu.se/english/research/researchers/mattias-alenius/)

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