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Journal club on the Node

Figure 1 Schematic of the clock model as proposed by Thorogood (1991). (A) The bold arrow represents the timing of the AER-to-AF transition in the developmental process. (B-D) Hypothesized representations of fin/limb development in the clock model (above) with endochondral skeletal patterns of the fin/limb (below,). (B) Fin development in a teleost, demonstrating a short period of time with AER signaling prior to the AER-to-AF transition. (C) Fin development in lobe-finned fishes, showing a longer relative time with AER signaling prior to AF transformation. (D) Limb development in a tetrapod, in which AER signaling persists throughout limb development. Figure modified from Yano et al. [3]; based on Thorogood [2]; with fossil form representations in C-D from Long et al. [4].

If I could turn back time: an embryological look at the fin-to-limb transition

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Stem Cells in Developmental Biology: a debate at the BSDB

On how odd critters can answer important questions

Select a Development cover image from the Woods Hole course

Posted by on February 28th, 2011

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Last summer you’ve been able to follow the experiences of a few of the students of the Woods Hole embryology course on the Node. You could tell from their stories that they learned different imaging techniques and studied a range of unique organisms.

The images produced in this course deserve a much wider audience, so Development has reserved some covers for images from the Woods Hole embryology course. The problem: there were far too many great images! We’ve made a selection, together with course co-director Nipam Patel, to narrow it down to the images that pass all the technical requirements for a cover, and now it’s down to you, the readers of the Node, to choose which ones you’d like to see as a journal cover.

There are four batches of images, so we’ll ask again a few more times, but here is the first group. Which of these images would you like to see on the cover of Development? Please vote in the poll below the images. (Click any image to see a larger version.) You can vote until March 8, 12:00 (noon) GMT

1. Mouth of an adult sea urchin feeding on a fragment of seaweed.


2. Germband extended stage Drosophila embryo.  Confocal image (extended focus) showing the expression of Engrailed (orange) and Vasa (green).  Dividing cells are highlighted in pink (PhosphoH3), and remaining nuclei are blue (DAPI).


3. Zebrafish embryo with cells of the gut highlighted in purple.


4. Squid embryo visualized by a combination of brightfield and fluorescence imaging (DAPI in blue and phalloidin in red).



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  1. Kalin D Narov says:
    February 28, 2011 at 12:24 PM
    my vote was partly biased of course for so little we know in regard to cephalopodan developmental processes, while the rest of the photos, despite their beauty, represent well known model systems :)


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    • Eva Amsen says:
      February 28, 2011 at 1:26 PM
      For fans of squid, I can tell you there’ll be more cephalopods coming up in future voting rounds, as well as a few other uncommonly studied organisms.


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  2. Billie Swalla says:
    February 28, 2011 at 6:36 PM
    I love these beautiful photos! The squid is so unusual, though, it was my favorite - and many others, as it turned out.


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  3. Susan says:
    March 7, 2011 at 9:40 PM
    Team Squid!!!!!!


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