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Displaying posts with the tag: cytoskeleton [Clear Filter]

The people behind the papers – Samira Benhamouche-Trouillet, Evan O’Loughlin & Andrea McClatchey

Posted by on May 21st, 2018

Intrahepatic bile ducts (IHBDs) are epithelial tubular structures that transport bile from the liver to the intestine, but the molecules and mechanisms controlling IHBD morphogenesis have remained largely unclear. A a recent paper in Development reports an investigation into IHBD development and the role the tumour suppressor and cytoskeletal regulator Merlin plays in the process. We caught[…]

The people behind the papers – You Wu & Mineko Kengaku

Posted by on March 12th, 2018

Neuronal migration is critical for mammalian brain development. In many migrating neurons, the nucleus translocates from the trailing to the leading edge of the cell in a manner dependent on the actin and microtubule cytoskeletons, but how these cytoskeletons interact and their relative contribution to the forces that move the nucleus has remained unclear. This[…]

A journey towards uncovering the mechanics of embryonic polarization

Posted by on February 17th, 2018

The key results of our recent paper in Nature Cell Biology   Cell polarization defines the spatial biological specificities in a cell. During the first cell cycle of a C. elegans zygote, its symmetry is broken by local remodeling of the cortical actomyosin network. This leads to a segregation of the dedicated polarity regulators, the PAR[…]

Manchester PhD position on neuronal development, ageing & degeneration

Posted by on October 17th, 2017

The University of Manchester, 2018/19 BBSRC DTP PhD Project Understanding tubulin regulation during neuronal development, ageing and degeneration Axons are slender, up-to-a-meter long, cable-like extensions of neurons which form the nerves and nerve tracts that wire our bodies and brain. These delicate cellular structures have to be maintained for an organism’s life time and are[…]

The people behind the papers – Diane Shakes & friends

Posted by on September 20th, 2017

Development often involves the asymmetric partitioning of cellular components to daughters, and this process is crucial for successful gametogenesis. Today’s paper, published in the current issue of Development, explores the cytoskeletal mechanisms of spermatogenesis in different nematode species. We met the multi-lab team behind the work, starting with Diane Shakes (The College of William and Mary in[…]

Nuclear sponges in embryonic stem cells

Posted by on June 17th, 2014

Once upon a time, physicists got curious about the cytoskeleton. They characterised the cytoskeleton – using tools of soft matter, statistical and polymer physics – as a mesoscale material whose physical properties govern its dynamics. They showed that the cytoskeleton is an interconnected scaffold that, depending on the time scale, can behave like a shape-morphing[…]

Cellular Architectures at the Nuit Blanche 2013 in Paris

Posted by on April 9th, 2014

The “Nuit Blanche” in Paris. A city wide exposition of contemporary arts from dusk till dawn. Performances, light shows, dance, installations. Along the Canal Saint-Martin the visitors stroll from one exhibition to the next or sit down and take a break, chatting and drinking. A bit further up Boulevard Avenue Richerand the south-west entrance to[…]