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New embryo phenotype data from the DMDD programme

Posted by on June 15th, 2018

Following our latest data release, the DMDD website (dmdd.org.uk) now contains detailed phenotype data for nearly 700 embryos from 82 different knockout mouse lines. Highlights include the identification of limb defects and cysts in Col4a2 knockouts and replication of the major features of Meckel syndrome in B9d2 knockouts. We have begun to add immunohistochemistry image[…]

Biocurator position at Xenbase

Posted by on August 9th, 2017

Curator position at Xenbase, the Xenopus Model Organism database Xenbase (www.xenbase.org) is the Xenopus bioinformatics and genomics resource. Xenopus is a major model for fundamental cell and developmental biology and a model for human disease. Xenbase is a totally free, and globally accessible database, used by Xenopus researchers worldwide, and is funded by the National[…]

Enabling research with human embryonic and fetal tissue resources

Posted by on September 24th, 2015

This Spotlight article was written by Dianne Gerrelli, Steven Lisgo, Andrew J. Copp and Susan Lindsay, and was first published in Development.   Congenital anomalies are a significant burden on human health. Understanding the developmental origins of such anomalies is key to developing potential therapies. The Human Developmental Biology Resource (HDBR), based in London and Newcastle, UK, was established to provide embryonic[…]

An illustrated anatomical ontology of the developing mouse lower urogenital tract

Posted by on May 25th, 2015

Georgas et al. have presented a comprehensive update to the anatomical ontology of the murine urogenital system. These updates pertain to the lower urinary tract, genital tubercle and associated reproductive structures, covering stage E10.5 through to adult. The updates have been based on recently published insights into the cellular and gross anatomy of these structures,[…]

Report on GUDMAP Outreach at ISN World Congress of Nephrology (ISN WCN)

Posted by on March 30th, 2015

Report on GUDMAP Outreach at ISN World Congress of Nephrology (ISN WCN) March 13-17, 2015 Cape Town, South Africa Author: Chris Armit Date: 23rd March 2015 Introduction The International Society of Nephrology (ISN) holds biennial meetings throughout the world, and this was the first ISN WCN to be held in Africa. There was attention brought[…]

Mapping the Embryo for Developmental Biologists & Stem Cell Researchers; LifeMap Discovery® – a Roadmap of Mammalian Cell Ontology

Posted by on March 30th, 2014

Understanding how cells differentiate during embryonic development is invaluable for the in vitro derivation of functional cells from stem cells. However, mapping the human embryo, including characterization of all the cell types that make up the developing and mature human body, and of all embryonic progenitor cell types that appear in intermediate developmental stages, is[…]

GUDMAP – an online resource for genitourinary research

Posted by on February 26th, 2014

GUDMAP (Harding et al., 2011, McMahon et al., 2008) is an open-access atlas-based on-line resource developed by a consortium of laboratories to provide the scientific and medical community with resources to facilitate research and teaching focussed on the murine genitourinary (GU) system. Gene expression data, descriptors of new mouse lines, and other tools can be[…]

Data mining with Manteia

Posted by on November 15th, 2013

Following the publication in Nucleic Acids Research of my new database that I developed in Olivier Pourquié’s lab, I would like to introduce you to Manteia http://manteia.igbmc.fr/. This database contains a lot of information (genomic, regulation, interaction, phenotype, disease etc …) for animal models (mouse, chicken, zebrafish) and man. These data are all formatted so[…]