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Displaying posts with the tag: epigenetics [Clear Filter]

Postdoc – Epigenomics of spiral cleavage

Posted by on December 19th, 2018

An ERC-funded Postdoctoral Research Assistant position is available at Queen Mary University of London (QMUL) in Dr José M (Chema) Martín-Durán’s group, to work on the epigenetic regulation of conditional and autonomous development in spiral cleaving animals (e.g. annelid worms, molluscs, and nemerteans).   Queen Mary is one of the top research-led universities in the[…]

PhD – DNA methylation in annelids

Posted by on December 19th, 2018

DNA methylation is a major mechanism for regulating gene expression in mammals, and it is often altered in prevalent human diseases like cancers. While common invertebrate biomedical systems, such as Drosophila melanogaster and C. elegans, lack this epigenetic mark, spiralians (e.g. molluscs and annelids) exhibit significant levels of DNA methylation. In collaboration with Dr Robert[…]

‘Chromatin-based regulation of development’ – Early-career researcher places available

Posted by on October 15th, 2018

The Company of Biologists’ Workshops provide leading experts and early career scientists from a diverse range of scientific backgrounds with a stimulating environment for the cross fertilization of interdisciplinary ideas. The April 2019 Workshop looks a treat for fans of developmental gene regulation. Co-organised by Benoit Bruneau and Joanna Wysocka, ‘Chromatin-based regulation of development‘ will bring together scientists who[…]

Postdoc – The evolution of spiral cleavage

Posted by on October 4th, 2018

An ERC-funded Postdoctoral Research Assistant position is available at Queen Mary University of London in Dr José M (Chema) Martín-Durán’s group. The project focuses on the epigenetic regulation of conditional and autonomous development in spiral cleavage. Queen Mary is one of the top research-led universities in the UK and was ranked 9th among the UK[…]

The people behind the papers – Anjali Rao & Carole LaBonne

Posted by on August 9th, 2018

The neural crest is a progenitor population with the capacity to contribute to all vertebrate germ layers. The transcription factor and signalling pathway activity underlying this remarkable pluripotency have been well studied, but the role of the epigenetic state is less well understood. A new paper in Development examines the role of histone acetylation in regulating[…]

Postdoctoral Position in Pluripotency, Signaling and Epigenetics, Washington University School of Medicine

Posted by on July 13th, 2018

A postdoctoral position is available in the lab of Thorold Theunissen at Washington University School of Medicine in St. Louis, Missouri, USA (theunissenlab.wustl.edu). Our research program is dedicated to exploring the molecular regulation of pluripotent stem cells and their applications in regenerative medicine. We have developed methods for inducing and maintaining human embryonic stem cells[…]

PostDoc Position on Ageing and Fertility in the Payer Lab (CRG Barcelona)

Posted by on July 11th, 2018

We are looking for a highly skilled and motivated candidate to join our group for a PostDoc position. In the Payer lab (http://www.crg.eu/bernhard_payer), we study epigenetic reprogramming in the mammalian germ line and the effects of ageing on fertility. In this project the prospective candidate will study the molecular links between ageing and oocyte quality decline[…]

The people behind the papers – Jinjin Zhu & Justin Kumar

Posted by on April 9th, 2018

Cell fate commitment relies on both activation of appropriate genes and suppression of inappropriate ones. Polycomb group proteins are known to be crucial epigenetic silencers of developmental genes, but the manner by which they control fate in vivo, and the relative roles of different Polycomb proteins in silencing, have remained unclear. A new paper in Development[…]

In vivo profiling of chromatin accessibility with CATaDa

Posted by on March 13th, 2018

The following post is an introduction into the technnique described in our recent paper: Aughey, G.N., et al., CATaDa reveals global remodelling of chromatin accessibility during stem cell differentiation in vivo. Elife, 2018. 7.   Attempting to understand the biology of a complex organ, like the brain, comes with an array of technical challenges. Those[…]

Silencing transposons during epigenetic reprogramming

Posted by on November 8th, 2017

Molecules called endosiRNAs help us avoid genetic chaos, according to a new study from a team at the Babraham Institute. Much of the human genome contains pieces of DNA called transposons, a form of genetic parasite. When active, transposons can damage genes so it is important to keep them inactive. At a certain point early[…]