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Layered patterning systems in hair development

Posted by on September 28th, 2017

The story behind our recent paper  ‘Hierarchical patterning modes orchestrate hair follicle morphogenesis‘ , finding that distinct patterning mechanisms can co-exist during embryonic organ formation.   From the spots of a leopard and stripes on a zebra to the pigmentation of sea shells and arrangement of sand dunes in a desert, repeating patterns are present[…]

Specifying stem cells, specifically

Posted by on February 5th, 2015

Bone marrow transplants save lives. It’s as simple as that. The reason bone marrow transplants are so effective is because this squishy tissue is home to haematopoietic stem cells (HSCs), which spend their lives happily producing every single blood cell that will ever circulate around your body. As a result, if anything goes wrong with[…]

GATA6 and the power of single cells

Posted by on May 29th, 2014

Any mammal who celebrated Mother’s Day earlier this month realizes how important mothers are for us and the tight bond between them and their children. Forget clean shirts and packed lunch every day; for us developmental biologists, there is no better reflection of this bond than the extraembryonic membranes that support the growth of the[…]

Postdoctoral position – MRC Department of Biomedical/Developmental Genetics, University of Sheffield, UK

Posted by on October 26th, 2011

Overview The Research Associate will work in the MRC Centre for Developmental and Biomedical Genetics within the Department of Biomedical Science.  The department has an active community of researchers specialising in different aspects of developmental biology.  You will take part in a project aiming to understand how cell proliferation is temporally integrated with digit patterning[…]

Cinematic Highlights at the BSDB Meeting 2011

Posted by on July 5th, 2011

As promised, in this final part of my meeting report on the BSCB-BSDB Spring Conference 2011 I will highlight a couple of talks which came with visual effects – studies involving live imaging. I prefer to watch these movies in seminars rather than downloading them with a paper because getting live explanations can make things[…]

In Development this week (Vol. 137, Issue 22)

Posted by on October 26th, 2010

Research highlights from the current issue of Development: Novel Hh targets fly in Hedgehog (Hh), a secreted morphogen, acts in a paracrine fashion to regulate tissue patterning during embryogenesis. Its tissue-specific effects are mediated by the transcription factor Cubitus interruptus (Ci), but how it exerts such effects is unclear. On p. 3887, Thomas Kornberg and[…]

In Development this week (Volume 137, Issue 18)

Posted by on August 24th, 2010

Non-muscle myosin II translates cilia polarity In the brain, cilia on the multiciliated ependymal cells that line the brain ventricles circulate cerebrospinal fluid over the brain surface. To generate this directional fluid flow, the ependymal cell cilia and their basal bodies must be orientated in one direction. This ‘rotational’ polarity is regulated by the planar[…]