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In Development this week (Vol. 144, Issue 20)

Posted by on October 17th, 2017

Here are the highlights from the current issue of Development:   Sequencing sheds light on human spermatogenesis In order to produce sperm, progenitor germ cells in the testes must undergo mitosis, meiosis, differentiation, and alter their chromatin structure to give rise to functional gametes. Much of our knowledge about how this complex process is controlled[…]

In Development this Week (Vol. 144, Issue 17)

Posted by on August 29th, 2017

Here are the highlights from the current issue of Development:   AdamTS-A keeps the CNS in shape The Drosophila central nervous system (CNS) is covered by a thick basement membrane that mediates interactions with glial cells and governs the shape of the tissue. Basement membranes are formed from a meshwork of secreted extracellular matrix (ECM) proteins and must be[…]

In Development this Week (Vol. 144, Issue 16)

Posted by on August 15th, 2017

Here are the highlights from the current issue of Development:   PLCζ ‘waves in’ mammalian oocyte activation At fertilisation, fusion of the sperm with the oocyte activates a slew of downstream processes to kick-start embryogenesis. This ‘oocyte activation’ event induces the cortical reaction to prevent polyspermy, triggers oocyte metabolic and DNA synthesis pathways, and reactivates meiosis. In[…]

In Development this Week (Vol. 144, Issue 15)

Posted by on August 1st, 2017

Here are the highlights from the current issue of Development:   X-citing insights into dosage compensation The non-coding RNA Xist plays a key role in the process of X chromosome inactivation (XCI) and is thus essential for dosage compensation of X-linked genes in females. The 5′ region of Xist RNA contains a conserved element termed the A-repeat that is required for[…]

In Development this week (Vol. 143, Issue 15)

Posted by on August 2nd, 2016

Here are the highlights from the current issue of Development:   Defining Polycomb complexes with AEBP2 Polycomb repressive complex 2 (PRC2) directs methylation of histone H3 K27 (H3K27me), a repressive histone mark. Mutations in PRC2 complex components cause a spectrum of developmental defects, including posterior transformation of the skeleton due to misexpression of Hox cluster[…]

In Development, Vol 137 (Issue 14)

Posted by on June 23rd, 2010

Here are the research highlights from the current issue of Development. You can find these on the Development site but we thought it would be useful to have them posted on the Node, too. Brainy signals for actin dynamics During brain development, neurite outgrowth and neuronal migration establish the brain architecture needed for brain function.[…]