This is the latest dispatch from a recipient of a Development Travelling Fellowship, funded by our publisher The Company of Biologists. Learn more about the scheme, including how to apply, here, and read more stories from the Fellows here. Estefanía Sánchez-Vásquez (Peruvian woman doing a PhD in Argentina) Lately there is much discussion of[…]
This is the latest dispatch from a recipient of a Development Travelling Fellowship, funded by our publisher The Company of Biologists. Learn more about the scheme, including how to apply, here, and read more stories from the Fellows here. Barbara Swierczek I am a PhD student at the University of Warsaw in Poland. In[…]
SCHOOL OF BIOLOGICAL SCIENCES, UNIVERSITY OF EAST ANGLIA PhD POSITION AVAILABLE The role of microRNAs in neural crest development MicroRNAs (miR) are short, non-coding RNAs around 22 nucleotides long. They block gene expression either by translational repression or by causing the degradation of the mRNAs they bind to. They are involved in[…]
Here are the highlights from the current issue of Development: The skin-healing touch of Lhx2 Skin repair after injury involves the recruitment of undifferentiated progenitor cells from nearby hair follicles (HFs) into the regenerating epidermis. The bulge and the secondary hair germ of HFs contain distinct populations of epithelial stem cells, and now Vladimir Botchkarev[…]
Here are the research highlights from the current issue of Development: Cranial neural crest development: p53 faces up The tumour suppressor p53 plays multiple roles in the prevention of cancer but its developmental functions are less clear. Here (see p. 1827), Eldad Tzahor and colleagues elucidate the key role that p53 plays in craniofacial development.[…]
Here are the research highlights from the current issue of Development: A breath of fresh air: miRNAs regulate lung development Throughout development, a proper balance between the proliferation and differentiation of progenitor cells is essential but the gene regulatory networks that control this balance are only partly understood. Here, Edward Morrisey and colleagues report that[…]
Animals and Plants have hundreds of miRNAs with diverse roles in gene regulation. In humans, each miRNA family can control up to several hundred genes (or 500 to be exact, in humans). A loss of function in one, can lead to array of developmental defects. Similarly in plants, an miRNA mutant can have a variety of phenotypes. However, interestingly, many miRNAs only have one target, which is frequently a transcription factor that in turn, controls many genes itself. It’s really like a house of cards.
The Bicoid gradient, epigenetic control of BMP signalling, haematopoietic stem cells and more…here are the highlights from the current issue of Development: The Bicoid gradient gets into shape without nuclei Morphogen gradients provide key positional information during embryogenesis but how they are established is not well understood. A gradient of the transcription factor Bicoid is[…]