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Displaying posts with the tag: phenotype [Clear Filter]

9.5 million knockout mouse embryo images now available

Posted by on July 20th, 2017

A new set of DMDD embryo and placenta data has been released, taking our total dataset to 9.5 million images of around 1300 embryos. DMDD is a primary screen of embryonic lethal knockout mice, and all data can be freely accessed at dmdd.org.uk. Detailed phenotypes are available for embryos from 73 different knockout lines, and[…]

New complexities in relationship between gene mutation and embryo development

Posted by on April 11th, 2017

  A large-scale study of DMDD data has shown that inactivating the same gene in mouse embryos that are virtually genetically identical can result in a wide range and severity of physical abnormalities. This suggests that the relationship between gene mutation and embryo development is more complex than previously thought.     The study considered[…]

Why are geneticists measuring the webbing between mouse embryo fingers?

Posted by on February 21st, 2017

A new paper published in Journal of Anatomy shows that measuring the amount of inter-digital webbing in mouse embryos between 14 and 15 days gestation is the best way to find out their exact stage of development. So why is this important to a geneticist? If we want to discover a causal link between a gene[…]

New phenotype dataset available for embryonic-lethal mouse knockouts

Posted by on December 1st, 2016

    This post originally appeared on Annotations, the DMDD blog.   New image and phenotype data for embryos and placentas from embryonic lethal knockout mouse lines has been made available on the DMDD website today. The knockout data includes the ciliary gene Rpgrip1l as well as Atg16l1, a gene encoding a protein that forms[…]

New phenotype screen examines causes of neonatal death

Posted by on October 4th, 2016

This post first appeared on Annotations, the DMDD blog (blog.dmdd.org.uk). Around a third of targeted gene knockouts in mice are embryonic-lethal. But not all deaths occur during gestation – a significant number of gene knockouts result in death at or shortly after the time of birth. Mice from these knockout lines provide a valuable animal[…]

New DMDD embryonic-lethal mouse data now available

Posted by on August 15th, 2016

  This post was originally posted on the DMDD blog.   New embryonic-lethal knockout mouse lines are now available on the DMDD database. If you haven’t previously taken a look at our data (or even if you have) now would be a good time to explore our website.  We’ve added new embryo phenotype data and[…]

Colouring the Mouse Embryo

Posted by on August 13th, 2012

48 anatomical structures of the presented mouse embryo atlas are shown in 3D. Here is the backdrop for our recent paper in Development, “A novel 3D mouse embryo atlas based on micro-CT”.   With the human genome project complete, the sequence and the location of each gene in the genome is understood.  However, the understanding of[…]

The IMPC: a new era in mouse genetics

Posted by on April 26th, 2012

The sophistication of genetic tools and the relative ease of breeding and housing mean that the mouse is the most widely used mammalian organism for basic and biomedical research. The genotype-phenotype information that will emerge from the efforts of the International Mouse Phenotyping Consortium (IMPC), now well into its first year, will advance all areas[…]

WormBase: It’s not just for C. elegans anymore

Posted by on October 29th, 2010

WormBase — wormbase.org — is the central data repository for Caenorhabditis elegans and related nematodes. C. elegans is a well-known system for studying problems in developmental biology, the benefits of which I will quickly rehash here. Its rapid generation time from fertilized egg to gravid adult (3.5 days) and small size (1mM) permit 1000’s of[…]