In the last thirty years, tremendous progress has been made in the elucidation of the molecular and cellular mechanisms regulating membrane trafficking and turnover in mammalian cells, e.g., exocytosis, endocytosis and the lysosomal clearance of proteins and lipids through autophagy. The field is now able to explore how defects of membrane trafficking can lead to diseases, particularly neurodevelopmental and neurodegenerative disorders. The school will overview the last decades of seminal advances in the field: the lessons learned about regulated and unconventional exocytosis, the role of lysosomes in degradation and secretion, the dynamics, metabolism and signalling of lipids, and the role of the immune system in regulating the synapse and neuronal function.
Program
Day 1. Monday 14th
11-12. welcoming
13.00. Lunch
Secretion and degradation I
14:30. Thierry Galli: “Unconventional Secretion in the Nervous System”
16:00. Silvia Coco: “Mesenchymal Stem Cell Extracellular Vesicles: A New Challenge for Brain Diseases?”
Social Dinner.
Day 2. Tuesday 15th
Membrane Trafficking and neurodegeneration
9:00. Shawn Ferguson: “Lysosome Dysfunction in Neurodegenerative Disease”
10:30. Peter McPherson: “DENN-Domain-Mediated Regulation of Rab GTPases in Neurological Disease
Social Event: Visit of Como and Museum
13.30. Lunch
Membrane dynamics at the synapse
14:30. Kohji Takei: “Interplay between Membrane Dynamics and Cytoskeletal Dynamics”
16:00. Ira Milosevic “Towards understanding synaptic transmission in the ageing brain”
17:15. Coffee Break
17:30. Student Session I
Day 3. Wednesday 16th
Secretion and degradation I
9:00. Michele Solimena: “Secretory Granules/Large Dense Core Vesicles: The Other Side of Regulated Exocytosis. Lessons from the Pancreatic Islet Beta Cells””
10:30. Roberto Zoncu: “Lysosomes in Nutrient Sensing and Cellular Growth Control”
Social Event: visit of the Villa of Grumello and botanical Garden
13.30. Lunch
Membrane Trafficking and neurodegeneration II
14:30. Volker Haucke: “Lipid Switches in Cell Physiology: From Membrane Dynamics to Disease”
16:00. Gilbert Di Paolo: “Role of Lipids in Neurodegeneration”
17:15. Coffee Break
17:30. Student Session II
Day 4. Thursday 17th
Neuroimmunology
9:30. Michela Matteoli: “The Synapse as a Target of the Immune System: Role of Microglia”
10:30. Evelina Gatti: “Unconventional Secretion Linking Cellular Stress and Innate Sensing: Lessons for the Neuroimmune Dialogue”
Social Event: Sailing on the lake
Lunch
16:30. Davide Pozzi: “The Synapse as a Target of the Immune System: Role of Cytokines”
Day 5. Friday 18th
10:00. Keynote Lecture: Pietro De Camilli.
Introduced by Prof. Maria Paola Canevini
11:00. Final discussion with all speakers and students
13:00. Lunch
Departure
Organizing Committee
Michela Matteoli: Institute of Neuroscience (IN-CNR), National Research Council of Italy, Milan, Italy, Department of Biomedical Sciences, Humanitas University, Milan, Italy.
Thierry Galli: Université Paris Cité, Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM, Membrane Traffic in Healthy & Diseased Brain, Paris, France; GHU Paris psychiatrie neurosciences, Paris, France
Michele Solimena: Department of Molecular Diabetology, University Hospital and Faculty of Medicine, Technische Universität Dresden, Dresden, Germany
Davide Pozzi: Department of Biomedical Sciences, Humanitas University, Milan, Italy
Maria Paola Canevini: Department of Health Sciences, University of Milan, Milan, Italy.