Postdoc position in epigenetic and metabolic regulation of early mouse development at DanStem, University of Copenhagen

The Danish Stem Cell Center (DanStem) at Faculty of Health & Medical Sciences at the University of Copenhagen is looking for a Postdoctoral candidate to join the Żylicz group starting July 2020 or upon agreement with the chosen candidate.

A postdoctoral position is available in the group of Jan Żylicz at DanStem. The team studies fundamental mechanisms of early mouse development and stem cell biology. The Żylicz group wants to understand how metabolic and epigenetic mechanisms cooperate to regulate transcription during early development. In particular the team is interested in how metabolism regulates histone modifiers, and how these in turn affect lineage choice and embryo growth at around the time of implantation. To achieve this, the group utilizes both in vivo mouse models as well as in vitro stem cell culture systems and state-of the-art ultrasensitive transcriptomic, epigenomic and metabolomic techniques. This research project will employ high-throughput screening methods to uncover metallic regulators underpinning chromatin states of mouse stem cell models. Starting date for this position is the 1 June 2020, or upon agreement with the chosen candidate.

Job description:
We are seeking a highly motivated and ambitious post-doctoral candidate with a strong background in either stem cell and developmental biology and/or metabolomic research. The candidate implement high-throughput screening techniques to identify key metabolic players regulating chromatin states in vitro and in vivo. By using functional assays in combination with live imaging and ultra-sensitive chromatin mapping and metabolomic techniques the candidate will get at the underlying principles of epi-metabolic regulation.

About DanStem
The Novo Nordisk Foundation Center for Stem Cell Biology – DanStem – addresses basic research questions in stem cell and developmental biology and translates results from basic research into new strategies and targets for the development of new therapies for diabetes and cancer. DanStem was established as a result of a series of international recruitments coupled with internationally recognized research groups focused on insulin producing beta cells and cancer research already located at the University of Copenhagen.

Qualifications:

• Candidates must hold a PhD degree in cell/developmental/stem cell biology/metabolomics or similar, with a track-record of successful scientific work.
• Candidates should have a strong background in mouse genetics, cell biology and/or live cell imaging. Alternatively candidates with a background in metabolomics applied to animal models are also encouraged to apply.
• Previous experience in metabolomics, bioinformatics, next-generation sequencing, mouse embryology and/or stem cell culture are considered an advantage.
• Good English communication skills, both oral and written, are prerequisite for the successful candidate.

Terms of salary, work, and employment :
The employment is planned to start 1 July 2020 or upon agreement with the chosen candidate. The employment is initially for 2 years. The terms of employment are set according to the Agreement between the Ministry of Finance and The Danish Confederation of Professional Associations or other relevant professional organization. The position will be at the level of postdoctoral fellow and the basic salary according to seniority. Currently, the salary starts at 34.360 DKK/approx. 4,.590 Euro (October 2019-level). A supplement could be negotiated, dependent on the candidate ́s experiences and qualifications. In addition a monthly contribution of 17.1% of the salary is paid into a pension fund.

Non-Danish and Danish applicants may be eligible for tax reductions, if they hold a PhD degree and have not lived in Denmark the last 10 years.
The position is covered by the “Memorandum on Job Structure for Academic Staff at the Universities” of December 11, 2019.

Questions:
For further information contact Associate Professor Jan Żylicz, jan.zylicz@sund.ku.dk.

Foreign applicants may find the following links useful: www.ism.ku.dk (International Staff Mobility) and www.workingconditions.ku.dk.

How to apply
The application, in English, must be submitted electronically by clicking APPLY below.

The application must include:

1. Motivation letter
2. Curriculum vitae incl. education, experience, previous employments, language skills and other relevant skills
3. List of two references (full address, incl. email and phone number)
4. List of publications
5. Copy of diplomas/degree certificate(s)

Application deadline: April 14, 2020

The University of Copenhagen wishes to reflect the diversity of society and welcomes applications from all qualified candidates regardless of personal background.

Only applications received in time and consisting of the above listed documents will be considered.

Applications and/or any material received after deadline will not be taken into consideration.

The application will be assessed according to the Ministerial Order no. 284 of 25 April 2008 on the Appointment of Academic Staff at Universities.

Assessment procedure
After the expiry of the deadline for applications, the authorized recruitment manager selects applicants for assessment on the advice of the Appointments Committee. All applicants are then immediately notified whether their application has been passed for assessment by an expert assessment committee. Selected applicants are notified of the composition of the committee and each applicant has the opportunity to comment on the part of the assessment that relates to the applicant him/herself.

You can read about the recruitment process at http://employment.ku.dk/faculty/recruitment-process/

Interviews are expected to be held in weeks 20

University of Copenhagen wish to reflect the diversity of society and welcome applications from all qualified candidates regardless of age, disability, gender, nationality, race, religion or sexual orientation. Appointment will be based on merit alone.

 APPLY ONLINE

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