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About: basile

Biography:
How do we perceive sounds, gravity or head movements? It all starts during development, when sensory cells in the inner ear acquire a crown of motion detectors known as the stereocilia bundle. Our laboratory investigates the molecular mechanisms that corral and layer stereocilia into a functional bundle, a highly polarized architectural process that, when defective, results in deafness. My scientific experience is rooted in developmental biology using the mouse as a model system. Focusing on Hox gene regulation, my graduate research addressed axial identity along body axes, including neuron organization in the spinal cord and asymmetric digit formation in appendages (University of Geneva, Switzerland; Denis Duboule). My postdoctoral work identified Insc-LGN/Gpsm2-Galphai as a new protein complex responsible for the planar polarization of sensory hair cells in the inner ear (Institut de recherches cliniques de Montréal, Canada; Michel Cayouette). This latter work is the foundation for my independent research program at The Jackson Laboratory (Maine, USA), where I have a laboratory since 2015. http://tarchini-lab.org/
Website:
http://tarchini-lab.org/

Posts by basile:

Postdoctoral Associate – Cell Polarity and Development of the Inner Ear

Posted by on May 28th, 2017

    How do we perceive sounds, gravity or head movements? It all starts during development, when sensory cells in the inner ear acquire a crown of motion detectors known as the stereocilia bundle. The Tarchini laboratory investigates the molecular mechanisms that corral and layer stereocilia into a functional bundle, a highly polarized architectural process that,[…]