the community site for and by developmental biologists

The right information

Posted by on October 19th, 2017

Oscar H. Ocaña and M. Angela Nieto Comment on “A right-handed signalling pathway drives heart looping in vertebrates”. Nature 549, 86-90 (2017).   A fundamental aspect of vertebrates is their external bilateral symmetry, which has to some extent shaped evolutionary success. Not only is beauty associated with symmetry, enhancing an individual’s chance of mating but[…]

Lab technicians in Human Pluripotent Stem Cell-based Cell Therapy in Type 1 Diabetes

Posted by on October 19th, 2017

The goal of this project is to engineer therapeutically active islet-like aggregates for future cell therapy phase 1 trials in Type 1 Diabetes (T1D) Job description  The laboratory technicians will be responsible for the maintenance of the human pluripotent stem cell (hPSC) lab. The work will include expansion of human embryonic and induced pluripotent stem[…]

The people behind the papers – Sabrina Jan, Tinke Vormer, Sjoerd Repping and Ans MM van Pelt

Posted by on October 18th, 2017

During spermatogenesis, progenitor cells must undergo tightly regulated changes to produce functional gametes. However, the genetic control of this process in humans has eluded researchers. This week we feature a paper published in the latest issue of Development that describes the changing genetic expression of cell during spermatogenesis. The co-first authors Sabrina Jan and Tinke[…]

Copenhagen Bioscience PhD: Application for 2018 is open

Posted by on October 18th, 2017

The CPH Bioscience PhD programme is designed for international talents to come to Denmark and start their research careers at one of the NNF Research Centers. The Copenhagen Bioscience PhD programme recruits up to 16 motivated international students annually to launch their careers in the vibrant scientific environment of the Novo Nordisk Foundation Research Centers in Copenhagen.[…]

Manchester PhD position on neuronal development, ageing & degeneration

Posted by on October 17th, 2017

The University of Manchester, 2018/19 BBSRC DTP PhD Project Understanding tubulin regulation during neuronal development, ageing and degeneration Axons are slender, up-to-a-meter long, cable-like extensions of neurons which form the nerves and nerve tracts that wire our bodies and brain. These delicate cellular structures have to be maintained for an organism’s life time and are[…]

Forgotten classics: Making a monotreme

Posted by on October 17th, 2017

T. Thomson Flynn and J.P. Hill. 1939. The Development of the Monotrema – Part IV. Growth of the Ovarian Ovum, Maturation, Fertilisation and Early Cleavage. Transactions of the Zoological Society of London, 24, 445-623. T. Thomson Flynn and J.P. Hill. 1947. The Development of the Monotrema – Part VI. The Later Stages of Cleavage and[…]

SWBioDTP BBSRC PhD studentship open to work on Marchantia plant shape determination.

Posted by on October 17th, 2017

Supervisors: Dr Jill Harrison and Dr Martin Homer. Plant shapes range from tiny string or mat-like forms to massive multilayered upright forms with complex organ systems such as shoots, roots and leaves. Despite these wide differences in shape, many plant gene families are very ancient, predating shape diversification. We can therefore study mechanisms for shape[…]

BBSRC EASTBIO-funded PhD: Control of the ParaHox genes in chordate evolution and development

Posted by on October 17th, 2017

Supervisors: Dr David Ferrier (University of St Andrews) and Prof Kate Storey (University of Dundee)   This project will dissect the regulatory mechanisms of the chordate ParaHox genes (Gsx, Xlox/Pdx1 and Cdx), analysing regulatory elements of these genes in both the invertebrate sea squirt Ciona intestinalis and the vertebrate Gallus gallus (chicken). ParaHox genes are[…]

In Development this week (Vol. 144, Issue 20)

Posted by on October 17th, 2017

Here are the highlights from the current issue of Development:   Sequencing sheds light on human spermatogenesis In order to produce sperm, progenitor germ cells in the testes must undergo mitosis, meiosis, differentiation, and alter their chromatin structure to give rise to functional gametes. Much of our knowledge about how this complex process is controlled[…]

Postdoctoral positions to perform in vivo neural imaging at Northeastern University

Posted by on October 17th, 2017

We are accepting candidates for a postdoctoral research associate in our multidisciplinary research group. The Clark group at Northeastern University detects ions (Na, K, Ca, etc.) and small molecules (glucose, acetylcholine, etc.) as well as proteins, and we are working with the Monaghan group in Biology to detect chemicals in vivo.  In particular, we are[…]