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About: passinhas

I am interested in two essential aspects of regenerative medicine: vascular and blood stem cell biology. Blood stem cells arise from a specialised subset of endothelal cells, the haemogenic endothelium (HE). Thus, correct programming of the endothelial cell fate is crucial for the normal development of blood stem cells, but also of the endothelium itself.

Posts by passinhas:

2-year Postdoctoral position (University of Birmingham) – Research Fellow in Cardiovascular genetics and development

Posted by on February 13th, 2018

Applications are invited from outstanding individuals to work under the supervision of Dr Rui Monteiro, Birmingham Fellow, on a BHF funded research project to study the role of TGFb signalling in angiogenic and haemogenic endothelial cell programming. The Monteiro Lab are interested in learning how extrinsic signalling impinges on lineage fate decisions in development and[…]

Where does blood come from in the first place and how is it made?

Posted by on September 14th, 2016

Commentary on Transforming Growth Factor β Drives Hemogenic Endothelium Programming and the Transition to Hematopoietic Stem Cells in Developmental Cell, Volume 38, Issue 4, p358–370, 22 August 2016   Each of us has around 6 pints of blood. The blood contains a number of different types of cells, including oxygen-transporting red blood cells, disease-protecting white[…]