the community site for and by developmental biologists

YEN Conference 2018: Abstract submission and registration is open!

Posted by on April 11th, 2018

***Abstract Deadline is Saturday, 14th April!*** Young Embryologist Network Conference 2018 14th May 2018 The Francis Crick Institute, London, UK   This year we are pleased to announce Professor Wolf Reik as our keynote speaker. His research group, based at the Babraham Institute, investigates the roles of epigenetic gene regulation in mammalian development. We are also honoured to[…]

deadline tomorrow – EMBO practical course on 3D Developmental Imaging (July 2018 – Portugal)

Posted by on April 10th, 2018 Dear colleagues, Last day tomorrow to apply for the EMBO practical course on 3D Developmental Imaging (April 11th!). Are you a developmental biologist struggling with 3D imaging (confocal, 2p, light-shet, OPT)? Don’t miss this opportunity: registration fee INCLUDES meals, course materials, hotel and local transport, all made possible by generous sponsorship from EMBO, the[…]

The people behind the papers – Jinjin Zhu & Justin Kumar

Posted by on April 9th, 2018

Cell fate commitment relies on both activation of appropriate genes and suppression of inappropriate ones. Polycomb group proteins are known to be crucial epigenetic silencers of developmental genes, but the manner by which they control fate in vivo, and the relative roles of different Polycomb proteins in silencing, have remained unclear. A new paper in Development[…]

A tribute to parrots

Posted by on April 5th, 2018

In a previous blog, I have disgraced parrots by associating them with P-values and discrediting them for their mechanic repetition. Nevertheless, I admire the vivid colours of these multifaceted birds. Here, I want to make it up by dedicating a pseudo-colour look-up table (LUT) to parrots. The images produced by fluorescence microscopy are best displayed[…]

The people behind the papers – Rémi-Xavier Coux & Ruth Lehmann

Posted by on April 5th, 2018

Development and homeostasis depend crucially on the maintenance of cell identity, and in gamete-producing tissues the somatic/germline distinction is paramount. A recent paper in Development explores how cell identity is secured in the Drosophila ovary by studying the function of the conserved tumour suppressor L(3)mbt. To find out more about the story, we caught up with first author Rémi-Xavier[…]

March in preprints

Posted by on April 4th, 2018

One of the most talked about preprints this month was a corrigendum to that Nature Methods paper reporting widespread off-target mutations following CRISPR-Cas9 editing in  mice. The paper was challenged quickly on bioRxiv, and four days after the corrigendum went up, it was retracted, as reported by Retraction Watch! Blink and you’ll miss it. Otherwise this month[…]

James Briscoe announced as Development’s new Editor-in-Chief – Editorial & Interview

Posted by on March 27th, 2018

This editorial and interview appeared in Development, Vol 145 Issue 6   A new Editor-in-Chief for Development Sarah Bray, Kate Storey, Katherine Brown   As many of you will be aware, The Company of Biologists initiated a search last year for a new Editor-in-Chief for Development, after Olivier Pourquié announced his intention to step down[…]

Sensing and making sense of clonal fragmentation in developing tissues

Posted by on March 23rd, 2018

Steffen Rulands and Benjamin Simons A discussion of our recent paper: Rulands S et al., Universality of clone dynamics during tissue development. Nature Physics | doi:10.1038/s41567-018-0055-6   Often, the most enjoyable research projects are the ones that were never planned; and so it was with the current study.   In developmental biology, genetic lineage tracing[…]

Mechanical cues as developmental pacers that orchestrate morphogenesis

Posted by on March 22nd, 2018

In these lines I share with you some details of our recently published Nature paper. I will comment how this project was started and details which are not included in the manuscript. Finally, I will briefly comment on some questions we are working on today and others we believe are worth addressing in the future.[…]

From stem cells to human development: meeting reporter competition

Posted by on March 22nd, 2018

In September, Development is hosting the third of its highly successful series of meetings focusing on human developmental biology. Held in the Wotton House estate near Dorking in Surrey and organised by Paola Arlotta, Ali Brivanlou, Olivier Pourquié and Jason Spence, the meeting will cover the latest developments and future prospects for this rapidly evolving field (you[…]