Karel Dorey

I did my PhD in the laborarory of Giulio Superti-Furga (EMBL-Heidelberg, Germany) working on the regulation of the proto-oncogene c-Abl is regulated. I then wanted to apply my expertise in signalling in the context of an organism. I moved to Caroline Hill’s laboratory (Cancer Research UK, London Research Institute) to study the regulation of TGFb signalling in Xenopus. As the era of genomics was starting, I moved to Enrique Amaya’s laboratory (Gurdon Institute, Cambridge) to work with the diploid species Xenopus tropicalis. When I started my lab, I became interested in spinal cord development and regeneration. We were the first to report bulk and single-cell RNAseq studies on isolated spinal cords during regeneration. We generated the first knockout line in Xenopus deficient for spinal cord regeneration. We are now interested in the mechanisms regulating neurogenesis during regeneration and to translate this knowledge in a mammalian model of spinal cord injury to improve repair.