Founded in 1978, Genesis Research Trust, based at Imperial College London, is the largest collaboration of reproductive health researchers in the UK. It is the only charity of its kind to lie consistently at the heart of original leading-edge research investigating why and how things can go wrong with conception, pregnancy and birth; delivering real evidence-based results for medical treatments and outcomes of worldwide significance. Having already transformed the lives of many parents-to-be, we know that there is the potential to achieve far more and an urgent need to do so.