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Introducing ACME: the species-versatile fixation and dissociation solution for single cell analysis

Posted by on July 1st, 2020

This post highlights the approach and findings of a new research article available in preprint on BioRxiv. This feature was written by members of the Solana lab, authors of that paper. Single cell techniques are revolutionising biology, but at the moment they are largely limited to traditional model organisms and require access to specialised equipment[…]

Now we need arrest… A long journey into the end-of-flowering

Posted by on June 29th, 2020

By Tom Bennett & Catriona Walker   25th May 2020: Publication TB: The joy of seeing an article finally published is always slightly tempered by the long-drawn out process of peer review, re-writing, re-submission, re-review, proof-reading, required to get to that point. But the publication of our article ‘Auxin export from proximal fruit drives arrest[…]

Conversations with my parents (about adult chondrogenesis and spontaneous cartilage repair in the skate, Leucoraja erinacea)

Posted by on June 23rd, 2020

One night, during the summer of 2012, I found myself sitting in a cottage in Woods Hole, trying to explain to my parents why I’d spent much of my professional life studying the little skate (Figure 1). I was a postdoctoral fellow at Dalhousie University at the time, and working almost exclusively with skate as[…]

The story of my heart, from the bottom of my heart (says the Zebrafish)

Posted by on June 23rd, 2020

I started off as quite little—just one cell, in fact. No heart, no brain, no blood flowed in me and yet, somehow I found the motivation in me to divide. One me made two and two mes made four, till many tiny mes made me a full-fledged embryo with a heart full of hope. As[…]

An evolutionary fable: the black pencil and the rubber.

Posted by on June 18th, 2020

By Héloïse Dufour, Shigeyuki Koshikawa and Cédric Finet In this post we will discuss our recent paper entitled “Temporal flexibility of gene regulatory network underlies a novel wing pattern in flies” [1]. We initiated the present project in Sean Carroll’s lab where the pigmentation in drosophilids was used as a model to study evolutionary genetics.[…]

Postdoctoral research fellow position in stem cells and regeneration- Patel lab U. of Bristol

Posted by on June 12th, 2020

We are looking for a highly motivated, intellectually curious and creative postdoctoral research fellow with a strong interest in tissue maintenance, regeneration and ageing to join our lab.   The Patel lab at the School of Cellular and Molecular Medicine, University of Bristol studies how tissues regenerate themselves after damage and how they maintain themselves[…]

Pregnancy complications in assisted reproduction linked to a specific process

Posted by on June 9th, 2020

A Press Release from the University of Pennsylvania School of Medicine – see the Development paper by Lisa Vrooman, Marisa Bartolomei and colleagues here. An experimental study from researchers in the Perelman School of Medicine at the University of Pennsylvania links a specific procedure – embryo culture – that is part of the assisted reproduction[…]

Research Highlight #5: Leukemic stem cells from iPSCs

Posted by on June 9th, 2020

Today let’s delve into a curious case involving induced pluripotent stem cells (iPSCs) and leukemic stem cells (LSCs). Most blood cells derived from iPSCs are unable to engraft in immunodeficient mice. However, Wesely and colleagues observed an exceptionally high engraftment efficiency of cell lines derived from an individual affected by acute myeloid leukemia (AML). In[…]

Catch Me if You Can: An elusive underpinning for Arx(GCG)10+7-mediated apoptosis in X-linked infantile spasms syndrome

Posted by on June 3rd, 2020

This post highlights the approach and finding of a new research article published by Disease Models and Mechanisms (DMM). This feature is written by Olivia Howell as apart of a seminar at The University of Alabama (taught by DMM Editorial Board member, Prof. Guy Caldwell) on current topics related to use of animal and cellular[…]

Stripe by stripe, zebrafish model provides transparent look into Fibrolamellar Carcinoma mechanism

Posted by on June 3rd, 2020

This post highlights the approach and finding of a new research article published by Disease Models and Mechanisms (DMM). This feature is written by Joseph I. Kaluzny as apart of a seminar at The University of Alabama (taught by DMM Editorial Board member, Prof. Guy Caldwell) on current topics related to use of animal and[…]