the community site for and by developmental biologists
the community site for and by developmental biologists
Posted by Chii J Chan on June 26th, 2019
In this article I share with you a more personal, chronological account of how our story unfolds (recently published in Nature), and highlight some key events and insights that help guide the direction of the study, which are not described in the publication. Readers are welcome to refer to the publication for more technical details.[…]
Posted by the Node Interviews on April 9th, 2018
Cell fate commitment relies on both activation of appropriate genes and suppression of inappropriate ones. Polycomb group proteins are known to be crucial epigenetic silencers of developmental genes, but the manner by which they control fate in vivo, and the relative roles of different Polycomb proteins in silencing, have remained unclear. A new paper in Development[…]
Posted by the Node Interviews on April 5th, 2018
Development and homeostasis depend crucially on the maintenance of cell identity, and in gamete-producing tissues the somatic/germline distinction is paramount. A recent paper in Development explores how cell identity is secured in the Drosophila ovary by studying the function of the conserved tumour suppressor L(3)mbt. To find out more about the story, we caught up with first author Rémi-Xavier[…]
Posted by Andras on October 27th, 2017
Andras Paldi, Daniel Stockholm, Alice Moussy How do phenotypic differences between cells of the same clonal origin emerge? How exactly does the transition between the initial and final phenotypes occur? What happens in the cell during the transition? When there are two or more options, how is the choice made between them? How long does[…]
Posted by the Node on August 17th, 2017
This interview by Aidan Maartens originally appeared in Development, Volume 143, Issue 16. Jennifer Nichols is a Principal Investigator at the Cambridge Stem Cell Institute and Department of Physiology, Development and Neuroscience at the University of Cambridge, UK. Her lab works on lineage segregation and the establishment of pluripotency in the mammalian embryo. In 2017 she was[…]
