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Off and On: it’s more complicated than we thought.

Posted by on January 23rd, 2020

We learn fairly early on when becoming biologists that both development and an organism’s response to environmental stressors require turning the right set of genes on in the right cells, at the right time. Clearly, for “on” to be meaningful, other genes have to be “off,” and many disordered conditions are associated with misexpression of[…]

BSDB Gurdon/The Company of Biologists 2019 Summer Studentship Report – Lauren Mulcahy

Posted by on January 18th, 2020

Established by the British Society for Developmental Biology in 2014, The Gurdon/The Company of Biologists Summer Studentship scheme provides financial support to allow highly motivated undergraduate students an opportunity to engage in practical research during their summer vacation. Each year, ten successful applicants spend eight weeks in the research laboratories of their choices, and the feedback[…]

Chromatin and epigenetics in development: a Special Issue

Posted by on October 15th, 2019

This editorial was recently published in Development and written by our editors Benoit Bruneau, Haruhiko Koseki, Susan Strome, Maria-Elena Torres-Padilla. Check out the Special Issue’s full table of contents here. The development of an organism is regulated by tightly coordinated changes in gene expression. From zygotic gene activation, through to lineage specification and organogenesis, and into[…]

Meeting report: “Chromatin-based regulation of development”, an excellent Workshop by the Company of Biologists

Posted by on April 26th, 2019

How can a genome’s cis-regulatory potential drive robust gene expression throughout embryonic development? Do topologically associating domains (TADs) truly contribute to gene expression by spatially constraining the regulatory actions of cis-sequences? And might phase separation by multi-valent proteins also be involved in the regulation of genes and genomic regions? The recent Company of Biologists Workshop on[…]

Functional interrogation of the C-terminal domain of RNA polymerase II in fruit flies

Posted by on April 24th, 2019

Feiyue Lu and David Gilmour tell the story behind their recent paper in Molecular Cell RNA polymerase II (Pol II) is the enzyme responsible for transcribing most genes in eukaryotes. The C-terminal domain (CTD) is a highly repetitive, unstructured domain on the largest Pol II subunit, Rpb1. It consists of numerous repeats of seven amino acids[…]

Of Arms and Legs: Shedding light onto developmental gene regulation

Posted by on November 19th, 2018

Written and illustrated by: Bjørt K. Kragesteen, Malte Spielmann, and Guillaume Andrey.   In early development, the forelimb and hindlimb buds of tetrapods are morphologically uniform. However, as limb development proceeds, each individual tissue attains a characteristic morphology that ultimately defines the identity of a forelimb (arm) or a hindlimb (leg). How do undifferentiated limbs[…]

Chromatin-based regulation of development: Funded early-career places available

Posted by on November 19th, 2018

In April 2019, The Company of Biologists Workshop ‘Chromatin-based regulation of development‘ will be held in Wiston House, a 16th century Grade I listed building located at the foot of the South Downs in West Sussex. Organised by Benoit Bruneau and Joanna Wysocka, the workshop will foster discussion of what mechanisms related to chromatin biology are informing[…]

‘Chromatin-based regulation of development’ – Early-career researcher places available

Posted by on October 15th, 2018

The Company of Biologists’ Workshops provide leading experts and early career scientists from a diverse range of scientific backgrounds with a stimulating environment for the cross fertilization of interdisciplinary ideas. The April 2019 Workshop looks a treat for fans of developmental gene regulation. Co-organised by Benoit Bruneau and Joanna Wysocka, ‘Chromatin-based regulation of development‘ will bring together scientists who[…]

Evo-chromo: towards an integrative approach of chromatin dynamics across eukaryotes

Posted by on July 18th, 2018

***Deadline to apply for funded ECR places is July 20!***   In November, the Company of Biologists is hosting the latest in its series of Workshops. ‘Evo-chromo’ aims to integrate skills and interests of the fields of chromatin biology and evolutionary biology – if you are an early career researcher and this all sounds appealing[…]

Postdoctoral Positions – RNA pathways in development and disease – NIH/NCI

Posted by on April 19th, 2018

We have open postdoctoral positions in our lab. We are looking for researchers interested in understanding the mechanisms through which non-coding RNAs and RNA metabolic pathways regulate gene expression in mammals and how these mechanisms impact animal development and disease. Our lab uses a combination of mouse models and genetic tools together with biochemical and[…]