Applications are invited from outstanding individuals to work under the supervision of Dr Rui Monteiro, Birmingham Fellow, on a BHF funded research project to study the role of TGFb signalling in angiogenic and haemogenic endothelial cell programming. The Monteiro Lab are interested in learning how extrinsic signalling impinges on lineage fate decisions in development and how progenitors and stem cells carry out those decisions, with a particular emphasis on the Transforming Growth Factor β (TGFβ) pathway. Previous work in the lab demonstrated that TGFb1 and TGFb3 play different roles in programming haemogenic endothelium to become of blood stem cells in vivo (Monteiro et al, 2016). The Research Fellow will study the gene regulatory network that carries out the ligand-specific functions for TGFb1 and TGFb3 ligands in haemogenic and angiogenic endothelium in vivo. They will make use of several approaches, including genome editing with CRISPR/Cas9, transgenesis, fluorescence activated cell sorting and transcriptional and epigenetic profiling using zebrafish as a model.
The successful applicant will have a first degree and a PhD in developmental biology, molecular genetics, biology or in a related discipline relevant to the project. They will also have a strong background in molecular biology and previous experience with model organism and/or analysis of transcriptomic and epigenetic data.
Informal enquiries should be directed to Dr. Rui Monteiro (R.Monteiro@bham.ac.uk)
Starting salary is normally on Grade 7 according to experience.
Closing date: 10 March 2018 Reference: 58652
To download the details of this position and submit an electronic application online please go to https://www.birmingham.ac.uk/staff/jobs/index.aspx. Please quote the appropriate Job Ref in all enquiries, alternatively information can be obtained from www.hr.bham.ac.uk