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The people behind the papers – Sabrina Jan, Tinke Vormer, Sjoerd Repping and Ans MM van Pelt

Posted by on October 18th, 2017

During spermatogenesis, progenitor cells must undergo tightly regulated changes to produce functional gametes. However, the genetic control of this process in humans has eluded researchers. This week we feature a paper published in the latest issue of Development that describes the changing genetic expression of cell during spermatogenesis. The co-first authors Sabrina Jan and Tinke[…]

An interview with Jayaraj Rajagopal

Posted by on October 5th, 2017

This interview by Aidan Maartens appeared in Development, Vol 144 Issue 19   Jayaraj (Jay) Rajagopal is a Principal Investigator at the Center for Regenerative Medicine at Massachusetts General Hospital and an Associate Professor of Medicine at Harvard Medical School. A Howard Hughes Medical Institute Faculty Scholar, his lab works on the development and regeneration of[…]

The people behind the papers – Simon Lane and Keith Jones

Posted by on October 4th, 2017

Checkpoints ensure that mouse oocytes with DNA damage arrest in meiosis I, preventing non-viable embryo formation, however the mechanisms which activate this checkpoint have so far eluded researchers. This week we feature a paper published in the latest issue of Development that reveals that the unique ability of mouse oocytes to sense DNA damage by[…]

The people behind the papers – Dan Dickinson

Posted by on September 29th, 2017

Cell polarisation is crucial for normal development and controlled by complex molecular interactions in the cytoplasm and at the membrane. Today we feature a paper recently published in Developmental Cell that describes  a single-cell biochemistry technique and its insights into polarity protein dynamics the developing worm embryo. We caught up with first author Dan Dickinson, who carried out the work as a postdoc[…]

An interview with George Daley

Posted by on September 22nd, 2017

This interview by Aidan Maartens appeared in Development, Vol 144 Issue 18 George Daley is Dean of the Faculty of Medicine, Professor of Biological Chemistry and Molecular Pharmacology, and Caroline Shields Walker Professor of Medicine at Harvard Medical School. A former Howard Hughes Medical Institute Investigator and President of the International Society for Stem Cell[…]

The people behind the papers – Diane Shakes & friends

Posted by on September 20th, 2017

Development often involves the asymmetric partitioning of cellular components to daughters, and this process is crucial for successful gametogenesis. Today’s paper, published in the current issue of Development, explores the cytoskeletal mechanisms of spermatogenesis in different nematode species. We met the multi-lab team behind the work, starting with Diane Shakes (The College of William and Mary in[…]

An interview with Jenny Nichols

Posted by on August 17th, 2017

This interview by Aidan Maartens originally appeared in Development, Volume 143, Issue 16. Jennifer Nichols is a Principal Investigator at the Cambridge Stem Cell Institute and Department of Physiology, Development and Neuroscience at the University of Cambridge, UK. Her lab works on lineage segregation and the establishment of pluripotency in the mammalian embryo. In 2017 she was[…]

The people behind the papers: Alaa Hachem and John Parrington

Posted by on August 16th, 2017

Embryogenesis begins with fertilisation, and defective activation of the egg by the sperm is implicated in human infertility. Today’s paper, published in the most recent issue of Development, investigates the role of the sperm protein PLCζ in egg activation and the calcium oscillations that accompany it. We caught up with co-first author Alaa Hachem and his[…]

An interview with Jim Smith

Posted by on August 3rd, 2017

To interview Jim Smith I took a train to London and visited the Francis Crick Institute for the first time. The building had opened in 2016 and, by the time I visited, most if not all of the labs had settled in. Architecturally it was quite stunning, especially looking down from one of the higher[…]

The people behind the papers – Giri Dahal, Sarala Pradhan & Emily Bates

Posted by on August 2nd, 2017

Ion channels are famous for their roles in neurons and muscles, but the spectrum of phenotypes seen in ion channel mutants indicate a diversity of roles in development; the underlying mechanisms, however, have remained opaque. This week we feature a paper published in the latest issue of Development that reveals a link between potassium channels and morphogen[…]