Marchantia square

A day in the life of a Marchantia lab

J Knoblich square

An interview with Juergen Knoblich

brain sex differences squared

Adventures in Studying Brain Sex Differences

lung organoids

Three dimensional human lung tissue in a dish

How The Bird Got Its Beak

Posted by on May 28th, 2015

Nature’s most interesting secrets can sometimes be found in our own backyards. One such secret is related to all birds, those pigeons, thrushes and sparrows that we see everyday. This familiarity means that we do not think too much of birds passing them by on our way to work or school. However, if the birds […]
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In Development this week (Vol. 142, Issue 11)

Posted by on May 26th, 2015

Here are the highlights from the current issue of Development:   Hippo signalling: not just for growth The Hippo signalling pathway regulates organ growth: activation of the pathway inhibits proliferation and promotes apoptosis. The core pathway consists of two kinases, Hippo and Warts, along with their adaptor proteins. Warts phosphorylates and thus inactivates the transcriptional […]
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An illustrated anatomical ontology of the developing mouse lower urogenital tract

Posted by on May 25th, 2015

Georgas et al. have presented a comprehensive update to the anatomical ontology of the murine urogenital system. These updates pertain to the lower urinary tract, genital tubercle and associated reproductive structures, covering stage E10.5 through to adult. The updates have been based on recently published insights into the cellular and gross anatomy of these structures, […]
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Molecular Control of Embryonic Development

Posted by on May 22nd, 2015

On the twentieth anniversary of the Nobel Prize for research in fly embryonic development By Peng Kate Gao 2015 marks the twentieth year since developmental biologists Edward B. Lewis, Christiane Nüsslein-Volhard and Eric F. Wieschaus won the Nobel Prize for their discoveries on the genetic control of early embryonic development (Figure 1). This anniversary is […]
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From our sister journals- May 2015

Posted by on May 19th, 2015

Here is some developmental biology related content from other journals published by The Company of Biologists.       Xenopus as a developmental model of neuroblastoma Neuroblastoma (NB) is a paediatric form of cancer derived from the sympathetic nervous system. Recent genome-wide sequencing data suggest that often NB does not have a clear genetic cause, […]
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Camelid antibodies go fishing

Posted by on May 18th, 2015

Figure 1. “Cytoplasm”, illustration by David S. Goodsell, the Scripps Research Institute.   When contemplating the illustrations by David S. Goodsell (Figure 1), the first thing that stands out is how cells are packed full with those wonderful little machines we call proteins. They move, interact and change shape to produce cellular functions, so our ability […]
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Cell motion associated with stemness

Posted by on May 14th, 2015

Stem cells play crucial roles in development as well as tissue homeostasis, repair, and regeneration, and their dysregulation is involved in diseases and aging of the tissues. The stem cell is defined as a cell that has the ability to self-renew and also to produce differentiated progeny for a long-term. Yet, stem cells require other […]
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In Development this week (Vol. 142, Issue 10)

Posted by on May 12th, 2015

Here are the highlights from the current issue of Development:   Capping off sesamoid bone development Sesamoid bones are small, flat bones that are embedded within tendons. To date, it has been thought that these bones develop within tendons in response to mechanical signals, but now (on p. 1831) Elazar Zelzer and colleagues challenge this […]
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Adventures in Studying Brain Sex Differences

Posted by on May 8th, 2015

by Peg McCarthy and Bridget Nugent The biological phenomenon of hormonally induced sexual differentiation of the brain has been an empirical topic of study for over 50 years1 but much remains to be discovered in terms of both mechanism and functional impact. In the McCarthy lab we exploit the many advantages of the laboratory rat […]
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Three dimensional human lung tissue in a dish

Posted by on May 6th, 2015

Pioneering efforts by others have made enormous strides in our ability to generate human lung tissue from human pluripotent stem cells (hPSCs); however, these efforts have largely focused on deriving lung-specific cells as flat monolayer cultures or growing these cells on scaffolds 1-7. In our paper, published recently in the open access journal eLife 8, […]
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