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The right information

Posted by on October 19th, 2017

Oscar H. Ocaña and M. Angela Nieto Comment on “A right-handed signalling pathway drives heart looping in vertebrates”. Nature 549, 86-90 (2017).   A fundamental aspect of vertebrates is their external bilateral symmetry, which has to some extent shaped evolutionary success. Not only is beauty associated with symmetry, enhancing an individual’s chance of mating but[…]

Copenhagen Bioscience PhD: Application for 2018 is open

Posted by on October 18th, 2017

The CPH Bioscience PhD programme is designed for international talents to come to Denmark and start their research careers at one of the NNF Research Centers. The Copenhagen Bioscience PhD programme recruits up to 16 motivated international students annually to launch their careers in the vibrant scientific environment of the Novo Nordisk Foundation Research Centers in Copenhagen.[…]

Forgotten classics: Making a monotreme

Posted by on October 17th, 2017

T. Thomson Flynn and J.P. Hill. 1939. The Development of the Monotrema – Part IV. Growth of the Ovarian Ovum, Maturation, Fertilisation and Early Cleavage. Transactions of the Zoological Society of London, 24, 445-623. T. Thomson Flynn and J.P. Hill. 1947. The Development of the Monotrema – Part VI. The Later Stages of Cleavage and[…]

In Development this week (Vol. 144, Issue 20)

Posted by on October 17th, 2017

Here are the highlights from the current issue of Development:   Sequencing sheds light on human spermatogenesis In order to produce sperm, progenitor germ cells in the testes must undergo mitosis, meiosis, differentiation, and alter their chromatin structure to give rise to functional gametes. Much of our knowledge about how this complex process is controlled[…]

Adhesion and signaling by Collagen IV intercellular concentrations (CIVICs)

Posted by on October 16th, 2017

The Great Wall of Collagen IV During the long history of evolution, the key innovation that gave rise to animals with true tissues was the extracellular matrix, very conserved from sponges to humans [1]. Before I started my PhD in the lab of Jose C. Pastor-Pareja at Tsinghua University in Beijing, he had described how[…]

Switch the career after PhD

Posted by on October 16th, 2017

Dear Colleagues, I am PhD graduate in Biotechnology focusing on Insect Molecular Biology and Plant Virology. After completion of my PhD in Agriculture sector, I would like to switch my career to medical sciences or advance biotech tools like studies in stem cells, or CRISPR. Should I repeat PhD in medical sciences or is there[…]

A 10-Step “Protocol” for Antibody Search

Posted by on October 12th, 2017

I remember when I first started grad school. I was pumped about my project, examining the signaling and physiological role of a novel dopamine receptor complex. We had experienced research associates, state-of-the-art equipment, and bold hypotheses. I was ready to take the first step on the road of biomedical discoveries. Then I faced my first[…]

Two birds with one stone: CTCF control of dynamic gene expression during heart development.

Posted by on October 9th, 2017

CTCF binds to chromatin and is thought of as an architectural protein in the genome. If the genome were a text, CTCF would act like the punctuation marks, so that words are grouped together becoming meaningful sentences. When I started my PhD, the Manzanares lab had been fruitfully collaborating with that of Jose Luis Gómez-Skarmeta at[…]

Converting excellent spreadsheets to tidy data

Posted by on October 6th, 2017

Structuring data according to the ‘tidy data‘ standard simplifies data analysis and data visualisation. But understanding the structure of tidy data does not come naturally (in my experience), since it is quite different from the structure of data in spreadsheets or tables. Here, I explain how to convert typical spreadsheet data to tidy data to[…]

Why Independent Antibody Reviews? 5 Problems They Overcome to Facilitate Rigor & Reproducibility

Posted by on October 5th, 2017

  In the internet age, what’s the first thing you do before spending money on anything? Right: Go online and read reviews. Well, the same behavior applies with buying antibodies. We look to publications like “reviews,” to ensure antibodies have produced reliable data in similar experimental contexts.   While sifting through publications is the gold standard for finding[…]