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Scientists shed light on how cells with an incorrect number of chromosomes lead to tumour development

Posted by on February 9th, 2016

Aneuploid cells—that is to say those with an abnormal number of chromosomes—are found in most human tumours. A study conducted at IRB Barcelona on the fly Drosophila reveals how surviving aneuploid cells favour tumour development. Barcelona, Thursday 9th February 2016.- A recent analysis of 43,205 human tumours unveiled that 68% of solid tumours are aneuploid,[…]

Pluripotency in the mouse and beyond…

Posted by on February 4th, 2016

Preimplantation development establishes the founding cell population of the adult mammal in the epiblast. This naïve pluripotent state employs a unique hand of transcription factors to ensure epigenetic resetting and unbiased embryonic potential. In rodents, naïve pluripotency can be captured in the form of embryonic stem (ES) cells1-4, however other mammals have proven more refractory.[…]

Using the mouse to model human disease: increasing validity and reproducibility

Posted by on February 3rd, 2016

This editorial by Monica J. Justice and Paraminder Dhillon was first published in Disease Models & Mechanisms.   ABSTRACT Experiments that use the mouse as a model for disease have recently come under scrutiny because of the repeated failure of data, particularly derived from preclinical studies, to be replicated or translated to humans. The usefulness of[…]

In Development this week (Vol. 143, Issue 3 )

Posted by on February 2nd, 2016

Here are the highlights from the current issue of Development:   New insights into human neural crest induction Human neural crest (NC) cells are the precursors for a wide range of ectodermal and mesenchymal cell derivatives. Due to the inherent difficulties associated with early human embryonic studies, it is currently unclear exactly when NC cells[…]

From our sister journals- January 2016

Posted by on January 26th, 2016

Here is some developmental biology-related content from other journals published by The Company of Biologists.     Characterisation of Slc9a6 knockout heterozygous female mice Mutations in SLC9A6 are responsible for X-linked Christianson syndrome, a neurodevelopmental disease. Sikora and colleagues demonstrate that female mice heterozygous for a Slc9a6 knockout present mosaic neuropathology and similar but milder behavioural traits to those of affected[…]

Natural Pluripotency vs. Artificial Pluripotency

Posted by on January 20th, 2016

Pluripotency is the developmental potential of cells to become various types of mature cells in the body. During development, a pluripotent embryo progressively differentiates to give rise to mature cell types in the organism that form major organs such as the brain, heart, and kidneys. The transient nature of pluripotent cells, however, also makes it[…]

In Development this week (Vol. 143, Issue 2)

Posted by on January 20th, 2016

Here are the highlights from the current issue of Development:   Fishing out a role for Caveolin 1 in heart regeneration Unlike the adult mammalian heart, the adult zebrafish heart is able to regenerate lost muscle tissue following injury. The epicardial sheet covering the heart is required for this regeneration but the genes that underlie[…]

Regeneration thwarts ageing in newts

Posted by on January 17th, 2016

Konstantinos Sousounis and Panagiotis A. Tsonis   The human eye is built to deliver the sense of vision. The eye lens is one of the organs playing role in focusing the light to the retina. Lens injury or disease leads to blurriness or even blindness in human patients. This is not the case for newts.[…]

In Memory of Marcos Vidal (1974-2016)

Posted by on January 13th, 2016

This obituary was written by Ross Cagan and Eyal Gottlieb, and first appeared in Disease Models & Mechanisms.   With the untimely death of Marcos Vidal, we have lost a good friend and a creative, brilliant colleague who made important contributions to the field of cancer biology through fruit fly research. Marcos began his research into Drosophila at Ross Cagan’s laboratory in[…]

Forgotten classics- Cell layers in the shoot meristem

Posted by on January 12th, 2016

  Satina, S., Blakeslee, A.F., and Avery, A.G. (1940) Demonstration of the Three Germ Layers in the Shoot Apex of Datura by Means of Induced Polyploidy in Periclinal Chimeras. American Journal of Botany 27, 895-905 Recommended by Jane Langdale (University of Oxford)   If you read about plant development in textbooks you will be told[…]