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Visualizing our ‘gut instinct’

Posted by on May 19th, 2016

How on earth do we turn into a living, breathing, singing, speaking being, from just the fusion of two cells? Development is fascinating and mysterious. Stem cells are one component of how this intricate process unfolds, allowing the embryo to not have every type of cell from the start. Imagine if the only way our[…]

In Development this week (Vol. 143, Issue 10)

Posted by on May 17th, 2016

Here are the highlights from the current issue of Development:   How the zebrafish got its tail Posterior axis elongation is a crucial process during metazoan development. In principle, axial extension can be driven either by tissue growth or by tissue rearrangement – or by a combination of the two. In vertebrates, studies based primarily[…]

Postdoctoral Position in Anatomical Networks, Evo-Devo and Macroevolution

Posted by on May 17th, 2016

A Postdoctoral researcher is sought to join the Rui Diogo lab (www.ruidiogolab.com), at the Howard University College of Medicine, Department of Anatomy (Washington DC). For more details on the research done at the lab, and the papers/chapters/books published in recent years, see also: https://www.researchgate.net/profile/Rui_Diogo Diogo’s books: http://www.amazon.com/Rui-Diogo/e/B001JS2K96 We are interested in a candidate that will[…]

Forgotten classics- Genetic mosaics in Drosophila

Posted by on May 11th, 2016

Bryant, P.J., Schneiderman, H. A. (1969). Cell lineage, growth, and determination in the imaginal leg discs of Drosophila melanogaster. Developmental Biology 20, 263–290   Recommended by Peter Lawrence (University of Cambridge)     The first article in this series was the 1940 paper that first identified the number of cell layers in the shoot meristem.[…]

The Inaugural Sainsbury Lab Symposium on Induced Plant Development 2016

Posted by on May 9th, 2016

By: Erin Sparks and Matthias Benoit Set in the idyllic location of the Sainsbury Laboratory Cambridge University (SLCU) building adjacent to the Cambridge University Botanic Garden, the inaugural Sainsbury Lab Symposium (#SLS16 on Twitter) attracted over 100 researchers from across the world. This three-day symposium focused on the topic of Induced Plant Development and featured[…]

Back to basics: Unraveling the mystery of mammalian germ cell connectivity using lineage analysis

Posted by on May 9th, 2016

Lei Lei and Allan Spradling           Germ cells are unique among all metazoan cells in their ability to persist from one generation to the next. In seeking to understand how germ cells acquire and maintain immortality, a logical place to start with is the distinctive cell biological properties these cells display.[…]

Insights into the pathogenic role of UVRAG in intestinal dysplasia

Posted by on May 4th, 2016

This post highlights the approach and findings of a new research article published in Disease Models & Mechanisms: ‘Stem cell-specific endocytic degradation defects lead to intestinal dysplasia in Drosophila’. This feature was written by Elan Strange as part of a graduate level seminar at The University of Alabama (taught by DMM Editorial Board member, Prof.[…]

In Development this week (Vol. 143, Issue 9)

Posted by on May 3rd, 2016

Here are the highlights from the current issue of Development:   Making inroads into spermatogonial differentiation Differentiation of spermatogonial cells is a crucial part of spermatogenesis. Many of the key signalling pathways and molecules that are involved in spermatogonial differentiation have been identified, but their precise function at the cellular level as well as their[…]

From our sister journals- April 2016

Posted by on April 29th, 2016

Here is some developmental biology related content from other journals published by The Company of Biologists.           New neural crest EMT reporter Stewart and colleagues describe a novel neural crest EMT reporter for rapid in vivo drug screening in zebrafish. They use to identify a small-molecule EMT inhibitor that blocks this process by activating retinoic[…]

Untangling developmentally programmed obesity: role of the serotonin system

Posted by on April 27th, 2016

This post highlights the approach and findings of a new research article published in Disease Models and Mechanisms (DMM): ‘5-HT2A and 5-HT2C receptors as hypothalamic targets of developmental programming in male rats’. This feature was written by Richard Seeber as part of a graduate level seminar at The University of Alabama (taught by DMM Editorial Board[…]