avian featured

From SNPs to starlings: Avian Model Systems 2014, 5th-8th March

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Learning to Inject Platynereis Embryos

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Studying genealogy in cell clones

C.elegans featured

A day in the life of a C. elegans lab

Flippase recognition target: orientation matters, so why care?

Posted by on April 16th, 2014

FRT sites are used often (at least in Drosophila) for inducing deletions or “flipping out” of markers in transgenic constructs. When there are two FRTs sequences in tandem, after inducing flippase the DNA sequence that is between these two sites will be deleted. If two FRT sites are facing each other (or looking away), the […]
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Stone Soup Eyes

Posted by on April 16th, 2014

Another installment from the Developmental Neurobiology Students at Reed College. Hope you enjoy! It’s not often that you get to recount the classic tale of Stone Soup when thinking about developmental biology, but that’s exactly what we did when discussing an almost classic 2011 Nature paper from Yoshiki Sasai’s group. In the story, a grumpy […]
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Regenerating the aged thymus

Posted by on April 9th, 2014

The latest issue of Development includes a paper by Clare Blackburn and colleagues at the Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, showing that the aged mouse thymus can be regenerated in vivo by the upregulation of a single transcription factor, FOXN1. This work has generated quite a lot of interest in […]
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Identified a new possible target to combat muscle wasting

Posted by on April 9th, 2014

The pathological atrophy of skeletal muscle is a serious biomedical problem for which no effective treatment is currently available. Those most affected populations are the elderly diagnosed with sarcopenia and patients with cancer, AIDS, and other infectious diseases that develop cachexia. A study by scientists at the Institute for Research in Biomedicine (IRB), headed by […]
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In Development this week (Vol. 141, Issue 8)

Posted by on April 8th, 2014

Here are the highlights from the current issue of Development:   Spine-tingling new role for Sall4 Wnt, Fgf and retinoic acid signalling play a key role in patterning the posterior neural plate to form the midbrain, hindbrain and spinal cord. Despite intense study of Wnt signalling and neural patterning, only a few target transcription factors […]
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Green Eggs and Serrano Ham

Posted by on April 4th, 2014

Scenes from Seville (my pics) and a transgenic embryo  (A. Fernandez-Miñan)After over a decade working in Europe, I recently returned to Costa Rica to start a lab at the University of Costa Rica (UCR), in San José. Life in the Tropics has its perks, such as regular sightings of sloths and raccoons from my office […]
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Approaching limb regeneration in an emerging model crustacean

Posted by on April 1st, 2014

My name is Nikos. I just finished my PhD in the lab of Michalis Averof , starting my thesis at IMBB, in Crete and completing it at IGFL, in Lyon. My project aimed to introduce a new arthropod model to regeneration studies. Its main part was published recently (http://www.sciencemag.org/content/343/6172/788.abstract). In this Node post, I would […]
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Learning to Inject Platynereis Embryos

Posted by on March 31st, 2014

Hello!  My name is Maggie Pruitt and I am a postdoc in Dr. Stephan Schneider’s laboratory at Iowa State University.  At the beginning of this year, I had the wonderful opportunity to visit Dr. Detlev Arendt’s laboratory at EMBL in Heidelberg, Germany for two weeks.  This experience was possible due to a Development Travelling Fellowship […]
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Planarians…the key to regenerative medicine?

Posted by on March 31st, 2014

  Of all the animal models used in biology, the freshwater planarian flatworm is one of the most fascinating: first because roughly 10% of all planarian cells are stem cells, second because these worms can regenerate from almost any injury. This ability to regenerate entire organs (including their own heads!) makes them very popular for […]
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Mapping the Embryo for Developmental Biologists & Stem Cell Researchers; LifeMap Discovery® – a Roadmap of Mammalian Cell Ontology

Posted by on March 30th, 2014

Understanding how cells differentiate during embryonic development is invaluable for the in vitro derivation of functional cells from stem cells. However, mapping the human embryo, including characterization of all the cell types that make up the developing and mature human body, and of all embryonic progenitor cell types that appear in intermediate developmental stages, is […]
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