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In Development this week (Vol. 142, Issue 15)

Posted by on August 4th, 2015

Here are the highlights from the current issue of Development:   CHD4 restrains gene expression during lineage specification The first lineage-specification event in the early embryo generates the inner cell mass (ICM), which later gives rise to the embryo proper, and the trophectoderm (TE), which then develops into extra-embryonic tissues. This fate decision is known[…]

From our sister journals- July 2015

Posted by on July 28th, 2015

Here is some developmental biology related content from other journals published by The Company of Biologists.         Drosophila helps to elucidate the effects of radiation therapy Children who are exposed to cranial radiation therapy (CRT) to treat brain tumours are at increased risk later in life for neurocognitive, motor and seizure disorders.[…]

In Development this week (Vol. 142, Issue 14)

Posted by on July 21st, 2015

Here are the highlights from the current issue of Development:   HIF1α muscles in on regeneration During early development, skeletal muscle stem/progenitor cells (SMSPCs) are thought to reside in low O2 levels but how this hypoxic environment affects myogenesis in vivo is unclear. Here, Celeste Simon and colleagues investigate the role of hypoxia inducible factor[…]

In Development this week (Vol. 142, Issue 13)

Posted by on June 30th, 2015

Here are the highlights from the current issue of Development:   Controlling Traffic jam for niche specification Tissue stem cells are dependent on their local microenvironment – the niche – for regulation of self-renewal and differentiation. In the Drosophila male germline, the niche comprises a set of 8-10 somatic cells called hub cells, which are[…]

Nerves read the electrical topography of their microenvironment in making growth decisions

Posted by on June 29th, 2015

A really interesting recent paper on bioartificial limbs underscored the prospect of transplantation for problems in regenerative medicine. One key issue facing transplant technology is establishing appropriate innervation to the host. What factors control the amount of nerve emanating from an organ graft and the paths that this innervation takes? Alongside the familiar diffusible signaling[…]

Cellular Senescence in Regeneration

Posted by on June 28th, 2015

Salamanders are remarkable organisms. Following the amputation or loss of complex structures such as parts of their eyes, hearts and brains, tails -including the spinal cord-, jaws and even full limbs, they are able to set up a regeneration programme which leads to the exact replacement of the missing structure, even as adults. As such,[…]

Friendly hello and a bit about stress & adult hippocampal neurogenesis

Posted by on June 27th, 2015

This is my first post for the Node, so I thought I would introduce myself a little bit… I just finished my MSc in Experimental Psychology (Behavioural Neuroscience) and now I am striving towards becoming a science communicator. Although, I would like to share the research that I am interested in and was involved in,[…]

From our sister journals- June 2015

Posted by on June 22nd, 2015

Here is some developmental biology related content from other journals published by The Company of Biologists.       Elucidating pulmonary hypoplasia in ciliopathies Ciliopathies are developmental disorders caused by mutations in components of the primary cilium (a microtubule-based mechanosensor organelle present in many mammalian cells), and are usually characterised by multi-organ abnormalities. Congenital lung[…]

In Development this week (Vol. 142, Issue 12)

Posted by on June 16th, 2015

Here are the highlights from the current issue of Development:   New tool for myelin formation in vitro The myelination of axons by oligodendrocytes in the nervous system is crucial for neuron function and survival. Its disruption leads to permanent functional defects, as seen in numerous severe neurological pathologies. In order to study the developmental principles[…]

MorphoGraphX: A platform for quantifying morphogenesis in 4D

Posted by on June 15th, 2015

Quantifying shape, growth and gene expression at the cellular level are key to understanding morphogenesis, i.e. how organs are shaped. Many image processing tools have been developed towards this goal that operate on either 2D or 3D images. 2D tools are fast, easy to use, and typically involve datasets of modest size. However organs and[…]