the community site for developmental biologists

Displaying posts in the category: Research [Clear Filter]

In Development this week (Vol. 142, Issue 13)

Posted by on June 30th, 2015

Here are the highlights from the current issue of Development:   Controlling Traffic jam for niche specification Tissue stem cells are dependent on their local microenvironment – the niche – for regulation of self-renewal and differentiation. In the Drosophila male germline, the niche comprises a set of 8-10 somatic cells called hub cells, which are[…]

Nerves read the electrical topography of their microenvironment in making growth decisions

Posted by on June 29th, 2015

A really interesting recent paper on bioartificial limbs underscored the prospect of transplantation for problems in regenerative medicine. One key issue facing transplant technology is establishing appropriate innervation to the host. What factors control the amount of nerve emanating from an organ graft and the paths that this innervation takes? Alongside the familiar diffusible signaling[…]

Cellular Senescence in Regeneration

Posted by on June 28th, 2015

Salamanders are remarkable organisms. Following the amputation or loss of complex structures such as parts of their eyes, hearts and brains, tails -including the spinal cord-, jaws and even full limbs, they are able to set up a regeneration programme which leads to the exact replacement of the missing structure, even as adults. As such,[…]

Friendly hello and a bit about stress & adult hippocampal neurogenesis

Posted by on June 27th, 2015

This is my first post for the Node, so I thought I would introduce myself a little bit… I just finished my MSc in Experimental Psychology (Behavioural Neuroscience) and now I am striving towards becoming a science communicator. Although, I would like to share the research that I am interested in and was involved in,[…]

From our sister journals- June 2015

Posted by on June 22nd, 2015

Here is some developmental biology related content from other journals published by The Company of Biologists.       Elucidating pulmonary hypoplasia in ciliopathies Ciliopathies are developmental disorders caused by mutations in components of the primary cilium (a microtubule-based mechanosensor organelle present in many mammalian cells), and are usually characterised by multi-organ abnormalities. Congenital lung[…]

In Development this week (Vol. 142, Issue 12)

Posted by on June 16th, 2015

Here are the highlights from the current issue of Development:   New tool for myelin formation in vitro The myelination of axons by oligodendrocytes in the nervous system is crucial for neuron function and survival. Its disruption leads to permanent functional defects, as seen in numerous severe neurological pathologies. In order to study the developmental principles[…]

MorphoGraphX: A platform for quantifying morphogenesis in 4D

Posted by on June 15th, 2015

Quantifying shape, growth and gene expression at the cellular level are key to understanding morphogenesis, i.e. how organs are shaped. Many image processing tools have been developed towards this goal that operate on either 2D or 3D images. 2D tools are fast, easy to use, and typically involve datasets of modest size. However organs and[…]

Active hematopoietic sites in Drosophila Adult

Posted by on June 11th, 2015

Studies in the last decade have established Drosophila as the best invertebrate model to study hematopoiesis. Blood cell development in the fruitfly has been shown to have similarities to that of vertebrates both at the level of its origins and important signaling molecules necessary for their formation and differentiation (Evans et al., 2003). It was believed[…]

Cortical Microcircuit Assembly: The Migratory Path Matters

Posted by on June 10th, 2015

By Peng Kate Gao Developmental neuroscience has traditionally focused on understanding the structural assembly of the nervous system. However, recently it has increasingly been recognized that development also plays a key role in orchestrating the functional assembly of neural circuits1. The neocortex, the center of higher functions in the mammalian brain, can be characterized by its stereotypic lamination at[…]

The human sex ratio at conception and the conception of scientific “facts”

Posted by on June 9th, 2015

Few things interest many people more than sex. For some, this means interest in practices and partners. For others, it means producing a son. There is an ocean of claims about how to do this. A quick Google search reveals claims that a woman can up the odds of a son by taking cough syrup,[…]