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Question Of The Month- developmental biology funding

In Development this week (Vol. 142, Issue 8)

Posted by on April 7th, 2015

Here are the highlights from the current issue of Development:   Getting to the heart of human epicardial differentiation The epicardium is crucial for heart development and function, and it has also emerged as a potential source of multipotent progenitors that can contribute to heart repair. But how epicardial cells develop in humans and how […]
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Best method to measure force transmission between cells

Posted by on April 6th, 2015

We have been trying to implement FRET in the lab and transfect our cells with mechanical biosensors, but so far we haven’t managed to successfully force our cells to express our constructs. After some digging, we realised that this technique does not work for all cell types. Its success seems to be highly dependent on cell […]
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The small beginnings of gastruloids

Posted by on April 1st, 2015

Mouse embryonic stem cells (mESCs) are by definition cells that can self-renew (make identical copies of themselves) and specialize into any cell type of the body. Since their discovery, scientists have used them to produce various specialized cell types in culture but also to produce transgenic mouse lines. When injected into a mouse early embryo, […]
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Report on GUDMAP Outreach at ISN World Congress of Nephrology (ISN WCN)

Posted by on March 30th, 2015

Report on GUDMAP Outreach at ISN World Congress of Nephrology (ISN WCN) March 13-17, 2015 Cape Town, South Africa Author: Chris Armit Date: 23rd March 2015 Introduction The International Society of Nephrology (ISN) holds biennial meetings throughout the world, and this was the first ISN WCN to be held in Africa. There was attention brought […]
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In Development this week (Vol. 142, Issue 7)

Posted by on March 24th, 2015

Here are the highlights from the current issue of Development:   ActivinA-ting spiny neuron production from hPSCs The medium-sized spiny neurons, the main projection neurons of the striatum, are generated in the lateral ganglionic eminence (LGE) and degenerate in the early stages of Huntington’s disease (HD) – for which no pharmacological treatment is yet available. […]
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In Development this week (Vol. 142, Issue 6)

Posted by on March 10th, 2015

Here are the highlights from the current issue of Development:   Dmrt1: a common thread in sex determination Dmrt1 and its related genes play a key role in sex determination in a broad range of metazoan species. However, Dmrt1 has become dispensable for testis determination in mammals, and this function is instead carried out by […]
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In Development this week (Vol. 142, Issue 5)

Posted by on February 24th, 2015

Here are the highlights from the current issue of Development:   pancRNAs in early development Promoter-associated noncoding RNAs (pancRNAs) are a class of long noncoding RNAs, transcribed from bidirectional promoters and thought to be involved in promoting expression of the gene transcribed from the opposite strand. Takuya Imamura and colleagues (p.910) now set out to […]
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How to eradicate an organ

Posted by on February 11th, 2015

 Phreatichthys andruzzii, lateral view (left), frontal view (right) Adaptations of some fish species to their environment can be most peculiar, especially within cave dwelling kinds. The so called troglomorphisms slowly turn these fish into almost grotesque looking creatures with no eyes, lost pigments and no scales on the one hand, but with enhanced alternative sensory […]
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In Development this week (Vol. 142, Issue 4)

Posted by on February 10th, 2015

Here are the highlights from the current issue of Development:   Pathways to human hypothalamic neurons The dysfunction of hypothalamic neurons is implicated in a number of common diseases, including obesity, hypertension, and mood and sleep disorders. To date, studies of human hypothalamic neurons have been limited due to their inaccessibility, but now (on p. […]
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Specifying stem cells, specifically

Posted by on February 5th, 2015

Bone marrow transplants save lives. It’s as simple as that. The reason bone marrow transplants are so effective is because this squishy tissue is home to haematopoietic stem cells (HSCs), which spend their lives happily producing every single blood cell that will ever circulate around your body. As a result, if anything goes wrong with […]
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