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The evolution of an axon guidance model: from chemotaxis to haptotaxis

Posted by on May 16th, 2017

The canonical model The publication of Marc Tessier-Lavigne’s seminal Cell papers (1, 2) in 1994 describing the identification of netrin1 (from the Sanskrit word, netr, meaning “one who guides”) was a defining moment in my graduate career. My friends and I talked about those papers for weeks, from the incredible technical feat, the biochemical purification[…]

Our latest research on Hormonal regulation of temporal gene expression in neural stem cells

Posted by on May 16th, 2017

http://around.uoregon.edu/content/study-brain-formation-finds-possible-link-human-disease @ http://www.doelab.org/ elife https://elifesciences.org/content/6/e26287   (No Ratings Yet) Loading…

In Development this week (Vol. 144, Issue 10)

Posted by on May 16th, 2017

Here are the highlights from the current issue of Development: A new model for lineage segregation Lineage segregation during gastrulation has long been thought to be driven by differential cell adhesion and cortical tension among cells, which would together lead to a differential tissue surface tension (TST) and the spatial segregation of specific cell types.[…]

Biotagging: Behind the scenes (and beyond)

Posted by on May 16th, 2017

“It finally got accepted!”, fol­­lowed by “It’s finally out!” about a month later. I am certain this ‘finally’ feeling about their paper is very familiar to those well-acquainted with the peer review process, and it was no different for our recently published Resource article. The ‘biotagging paper’, as we call it within the Sauka-Spengler lab,[…]

Making of the nerve cord: The story of telling neural progenitors when and where not to divide

Posted by on May 5th, 2017

Comment on “Anterior-Posterior Gradient in Neural Stem and Daughter Cell Proliferation Governed by Spatial and Temporal Hox Control”, Current Biology 27, 1161-1172 (2017). Ignacio Monedero, Behzad Yaghmaeian, Stefan Thor. Department of Clinical and Experimental Medicine, Linkoping University, Sweden.   How cells are generated in proper numbers in order to form specific structures in an organism[…]

Postdoc position in the Frickel lab at Crick London

Posted by on May 5th, 2017

We are looking for a motivated, ambitious and collegial person interested in joining us as a postdoc to pursue projects centered around host-pathogen interaction in human stem cell derived macrophages. Prior exprience with stem cells or high throughput microscopy is required. Please contact Eva directly with your CV or with queries if you are interested.[…]

In Development this week (Vol. 144, Issue 9)

Posted by on May 2nd, 2017

Here are the highlights from the current issue of Development:   SEGGA: new software for analysing cell shape and dynamics Changes in epithelial cell shape and organisation are essential for tissue morphogenesis, regeneration and repair. In recent years, advances in microscopy have made it possible to capture these changes in living animals, but the quantitative[…]

Recognition and metrics for peer review activity: reviewercredits.com

Posted by on April 25th, 2017

In this post, I would like to introduce to “The Node” our website, reviewercredits.com, launched last July by myself and my friend Robert Fruscio. We are both physicians (I’m in critical care, he is in Gynecological oncology) and several times we chatted about peer review: we always realized how this activity is poorly recognized, despite[…]

New complexities in relationship between gene mutation and embryo development

Posted by on April 11th, 2017

  A large-scale study of DMDD data has shown that inactivating the same gene in mouse embryos that are virtually genetically identical can result in a wide range and severity of physical abnormalities. This suggests that the relationship between gene mutation and embryo development is more complex than previously thought.     The study considered[…]

In Development this week (Vol. 144, Issue 8)

Posted by on April 11th, 2017

Here are the highlights from the current issue of Development:   A new niche for human HSCs Human haematopoiesis occurs at various anatomical sites throughout development, including the yolk sac, the aorta-gonad-mesonephros region, the liver, the placenta and the bone marrow. Cells marked by high expression of CD34 and low CD45 – suggestive of possible[…]