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The Node is a place to share news about and with the developmental biology community around the world. If this is your first time on the site, check out this introduction to the Node. You can also find out more about us, and sign up to contribute.
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Stem cells…now showing in 3D
Posted by Christele Gonneau on January 22nd, 2015
Growing organs in vitro is one of the ultimate dreams of any stem cell biologist. As such, it seems obvious that some of these organs will need to be grown in 3D. This is why stem cell 3D culture systems are very fashionable among scientists. They are increasingly successful and a fair amount […]
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In Development this week (Vol. 142, Issue 3)
Posted by Seema Grewal on January 20th, 2015
Here are the highlights from the new issue of Development: Invadosomes: aiding axonal invasion Invasive cells such as immune and metastatic cancer cells form protrusions known as invadosomes, which mediate adhesion to the underlying substrate and induce extracellular matrix degradation – thus promoting invasiveness. On p. 486, Timothy Gomez and colleagues demonstrate that invadosomes […]
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In Development this week (Vol. 142, Issue 2)
Posted by Seema Grewal on January 6th, 2015
Here are the highlights from the new issue of Development: The ‘second brain’: taking gut development up a Notch The vertebrate gastro-intestinal (GI) tract consists of a regionalized epithelial tube surrounded by mesenchyme that later differentiates into smooth muscle. During the early stages of stomach patterning in chick embryos, the primitive GI track is […]
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The rabbit blastocyst modelling (for) vertebrate gastrulation
Posted by Christoph Viebahn on January 5th, 2015
Form and function of animal gastrulation have been longstanding classics accompanying the rise of experimental embryology, and – as if to square the circle in the literal sense – the blastopore of Haeckel’s original ‘gastrea’ stage[1] was soon (and still is) considered analogous to the straight primitive streak of birds and mammals[2-4]. Both forms are […]
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Of mice and men: exploring Mouse ENCODE
Posted by RebeccaL on December 17th, 2014
The Mouse ENCODE Project released a slew of papers late last month reporting findings from a three-year effort to comprehensively map functional elements in the mouse genome. Their major findings are summarized in an integrative paper in Nature (Yue, F. et. al., 2014). Similar to the goals of the human ENCODE project (The ENCODE Project Consortium, […]
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In Development this week (Vol. 142, Issue 1)
Posted by Seema Grewal on December 16th, 2014
Here are the highlights from the current issue of Development: Planar cell polarity squeezes in on the action The planar cell polarity (PCP) pathway regulates the polarization of epithelial tissues in various contexts, but recent studies suggest that the PCP pathway also influences other aspects of morphogenesis. Here, Sergei Sokol and colleagues uncover a […]
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Why Not Publish Your Antibody Validation Data
Posted by ac270 on December 15th, 2014
Antibodies are frequently used in developmental biology labs, but their validation is crucial to provide the information needed in order to reliably interpret the results of experiments. Antibody validation is also important to help scientists chose antibodies that will be suitable for their experiments, yet the results of these validations rarely get published. To try […]
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Seeing cells from a different angle
Posted by Christele Gonneau on December 7th, 2014
Thanks to microscopy, scientists can compete with the most talented photographers and take the most astonishing pictures! Although I have been focusing on microscopy pictures in this blog, microscopy is not the only way to make pretty pictures of cells. In recent years, the rapid progress in sequencing technology has propelled this technique to the […]
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EuroStemCell November 2014 Newsletter: World Diabetes Day
Posted by jbarfoot on December 4th, 2014
Hello! We’d like to start by offering our congratulations to Dr Masayo Takahashi who won 2014 Stem Cell Person of year! A fitting acknowledgement of her and her team’s, hard work. Also this month we marked World Diabetes Day on the 14th of November with a Twitter campaign and two pieces from the EC-funded HumEn research […]
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Nominations for the 2015 Beddington medal
Posted by BritSocDevBiol (BSDB) on December 1st, 2014
Nominations are invited for the 2015 Beddington Medal for the best graduating PhD student in the field of Developmental Biology. The eligibility period covers PhD dissertations submitted anytime during 2014. The closing date for nominations this year is Wednesday 14th January, 2015. Before submitting any nomination, please read further details here.
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- Invadosomes: aiding axonal invasion [IN THIS ISSUE]
- Taking the strain out of stem cell renewal [IN THIS ISSUE]
- Reporting on {beta}-catenin in the vasculature [IN THIS ISSUE]
- PUB4 calls time on root cell division [IN THIS ISSUE]
- Reaching out - the many faces of science outreach [SPOTLIGHT]
- Mathematically guided approaches to distinguish models of periodic patterning [HYPOTHESIS]
- Building a plant: cell fate specification in the early Arabidopsis embryo [REVIEW]
- Regulation of ECM degradation and axon guidance by growth cone invadosomes [RESEARCH ARTICLES]
- {beta}-catenin-dependent transcription is central to Bmp-mediated formation of venous vessels [RESEARCH ARTICLES]
- DNA hypomethylation induces a DNA replication-associated cell cycle arrest to block hepatic outgrowth in uhrf1 mutant zebrafish embryos [RESEARCH ARTICLES]
- ERBB3-mediated regulation of Bergmann glia proliferation in cerebellar lamination [RESEARCH ARTICLES]
- A transient wave of BMP signaling in the retina is necessary for Muller glial differentiation [RESEARCH ARTICLES]
- Surrounding tissues canalize motile cardiopharyngeal progenitors towards collective polarity and directed migration [RESEARCH ARTICLES]
- Ciliary proteins Bbs8 and Ift20 promote planar cell polarity in the cochlea [RESEARCH ARTICLES]
- A dynamic Shh expression pattern, regulated by SHH and BMP signaling, coordinates fusion of primordia in the amniote face [RESEARCH ARTICLES]
- SMAD2 and p38 signaling pathways act in concert to determine XY primordial germ cell fate in mice [RESEARCH ARTICLES]
- Selective synaptic targeting of the excitatory and inhibitory presynaptic organizers FGF22 and FGF7 [Articles of interest in other COB journals]
- The microRNA miR-17-3p inhibits mouse cardiac fibroblast senescence by targeting Par4 [Articles of interest in other COB journals]
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- Editorial Board
- From classical to current: Analyzing peripheral nervous system and spinal cord lineage and fate
- Maternal-zygotic knockout reveals a critical role of Cdx2 in the morula to blastocyst transition
- Comprehensive single cell-resolution analysis of the role of chromatin regulators in early C. elegans embryogenesis
- Ecdysone regulates morphogenesis and function of malpighian tubules in Drosophila melanogaster through EcR-B2 isoform
- Mapping the dynamic expression of Wnt11 and the lineage contribution of Wnt11-expressing cells during early mouse development
- Effects of polysialic acid on sensory innervation of the cornea
- Somatic insulin signaling regulates a germline starvation response in Drosophila egg chambers
- Heixuedian (heix), a potential melanotic tumor suppressor gene, exhibits specific spatial and temporal expression pattern during drosophila hematopoiesis
- Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development
- Foxp1/2/4 regulate endochondral ossification as a suppresser complex
- C. elegans NIMA-related kinases NEKL-2 and NEKL-3 are required for the completion of molting
- E3 ubiquitin ligases promote progression of differentiation during C. elegans embryogenesis
- Ascl1 and Helt act combinatorially to specify thalamic neuronal identity by repressing Dlxs activation
- Editorial Board
- Differential pleiotropy and HOX functional organization
- A method for using direct injection of plasmid DNA to study cis-regulatory element activity in F0 Xenopus embryos and tadpoles
- Developmental alterations of the C. elegans male anal depressor morphology and function require sex-specific cell autonomous and cell non-autonomous interactions
- PLR-1, a putative E3 ubiquitin ligase, controls cell polarity and axonal extensions in C. elegans
- Mechanics of blastopore closure during amphibian gastrulation
- CSN maintains the germline cellular microenvironment and controls the level of stem cell genes via distinct CRLs in testes of Drosophila melanogaster
- Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT
- Nf2–Yap signaling controls the expansion of DRG progenitors and glia during DRG development
- Three-dimensional cultures of trophoblast stem cells autonomously develop vascular-like spaces lined by trophoblast giant cells
- Molecular characterization of the apical organ of the anthozoan Nematostella vectensis
- miR-216a regulates snx5, a novel notch signaling pathway component, during zebrafish retinal development
- Juvenile skeletogenesis in anciently diverged sea urchin clades
- Fibroblast growth factor receptor-Frs2α signaling is critical for nephron progenitors
- Segmental border is defined by Ripply2-mediated Tbx6 repression independent of Mesp2
- BMP-Smad4 signaling Is required for precartilaginous mesenchymal condensation independent of Sox9 in the mouse
- Hedgehog signaling in prostate epithelial-mesenchymal growth regulation
- C. elegans OSM-11 signaling regulates SKN-1/Nrf during embryonic development and adult longevity and stress response
- Znf385C mediates a novel p53-dependent transcriptional switch to control timing of facial bone formation
- Fgf10 is required for specification of non-sensory regions of the cochlear epithelium
- Ecdysone response gene E78 controls ovarian germline stem cell niche formation and follicle survival in Drosophila
- Pluripotent stem cell derived cardiovascular progenitors – A developmental perspective
- Gene expression ontogeny of spermatogenesis in the marmoset uncovers primate characteristics during testicular development
- Evidence for intermediate mesoderm and kidney progenitor cell specification by Pax2 and PTIP dependent mechanisms
- RhoGAP68F controls transport of adhesion proteins in Rab4 endosomes to modulate epithelial morphogenesis of Drosophila leg discs
- The heparan sulfate-modifying enzyme glucuronyl C5-epimerase HSE-5 controls Caenorhabditis elegans Q neuroblast polarization during migration
- Loss of function of the yellow-e gene causes dehydration-induced mortality of adult Tribolium castaneum
- Co-expression of the transcription factors CEH-14 and TTX-1 regulates AFD neuron-specific genes gcy-8 and gcy-18 in C. elegans
- microRNAs regulate β-catenin of the Wnt signaling pathway in early sea urchin development
- Ontogeny of the mouse vocal fold epithelium
- Semi-solid tumor model in Xenopus laevis/gilli cloned tadpoles for intravital study of neovascularization, immune cells and melanophore infiltration
- The organizer in evolution–gastrulation and organizer gene expression highlight the importance of brachyury during development of the coral, Acropora millepora
- Editorial Board
- The BED finger domain protein MIG-39 halts migration of distal tip cells in Caenorhabditis elegans
- Pox neuro control of cell lineages that give rise to larval poly-innervated external sensory organs in Drosophila
- Pax8 and Pax2 are specifically required at different steps of Xenopus pronephros development
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- From equator to pole: splitting chromosomes in mitosis and meiosis [Reviews]
- A phosphorylation switch on RbBP5 regulates histone H3 Lys4 methylation [Research Communications]
- The transcription factor Nerfin-1 prevents reversion of neurons into neural stem cells [Research Papers]
- Terminal epidermal differentiation is regulated by the interaction of Fra-2/AP-1 with Ezh2 and ERK1/2 [Research Papers]
- Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth [Research Papers]
- ATDC induces an invasive switch in KRAS-induced pancreatic tumorigenesis [Research Papers]
- FBXL20-mediated Vps34 ubiquitination as a p53 controlled checkpoint in regulating autophagy and receptor degradation [Research Papers]
- Screen identifies bromodomain protein ZMYND8 in chromatin recognition of transcription-associated DNA damage that promotes homologous recombination [Research Papers]
- Genome-wide chromatin footprinting reveals changes in replication origin architecture induced by pre-RC assembly [Research Papers]
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- Hoxa2 Selectively Enhances Meis Binding to Change a Branchial Arch Ground State
- Rac1 Nucleocytoplasmic Shuttling Drives Nuclear Shape Changes and Tumor Invasion
- A Role for the Ancient SNARE Syntaxin 17 in Regulating Mitochondrial Division
- Endocytosis of Hedgehog through Dispatched Regulates Long-Range Signaling
- Actin-Delimited Adhesion-Independent Clustering of E-Cadherin Forms the Nanoscale Building Blocks of Adherens Junctions
- Interkinetic Nuclear Migration Is Centrosome Independent and Ensures Apical Cell Division to Maintain Tissue Integrity
- Salvador-Warts-Hippo Pathway in a Developmental Checkpoint Monitoring Helix-Loop-Helix Proteins
- Phosphorylation of Cohesin Rec11/SA3 by Casein Kinase 1 Promotes Homologous Recombination by Assembling the Meiotic Chromosome Axis
- Hypo- or Hyper-Hippo: A Balancing Act with bHLH Transcription Factors
- Enhancer Trafficking: Free Throws and Three-Pointers
- Sequential Contraction and Exchange of Apical Junctions Drives Zippering and Neural Tube Closure in a Simple Chordate
- Regulation of β1 Integrin-Klf2-Mediated Angiogenesis by CCM Proteins
- Functional Reprogramming of Polyploidization in Megakaryocytes
- The Cerebral Cavernous Malformation Pathway Controls Cardiac Development via Regulation of Endocardial MEKK3 Signaling and KLF Expression
- Casein Kinase 1 Promotes Initiation of Clathrin-Mediated Endocytosis
