Yoshiki Sasai

Yoshiki Sasai: stem cell Sensei

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Accelerated Frogs: Developmental Biology meets Particle Physics

Niteace

Interview with SDB poster winner Niteace Whittington

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An evolving field- notes from the European Evo Devo meeting

The origin of blood

Posted by on September 4th, 2014

As for the origin of species, the question of the origin of blood during development has unleashed a lot of passion among the scientific community. As a matter of fact, the failure to derive blood stem cells (haematopoietic stem cells, HSCs) from pluripotent stem cells (stem cells that can generate any type of cells) has […]
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Designing ChIP primers

Posted by on September 4th, 2014

Hello everyone, Recently I got assigned with the task of designing good primers for ChIP. My supervisor advised me to use the Primer BLAST tool from NCBI together with AmplifiX to get some computer-generated primers and at the same time test some I designed myself. Problem is we were discussing yesterday and eventually we came […]
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Researchers grow ‘seed’ of spinal cord tissue in a dish

Posted by on September 3rd, 2014

Medical Research Council (MRC) scientists have for the first time managed to turn stem cells into the specialised cells that go on to form spinal cord, muscle and bone tissue in the growing embryo. Their discovery could lead to a new way of studying degenerative conditions such as spinal muscular atrophy, which affects the nerve […]
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In Development this week (Vol. 141, Issue 18)

Posted by on September 2nd, 2014

Here are the highlights from the current issue of Development:   Mcc: a new player in gastrulation The mutated in molorectal cancer (Mcc) gene has been described as a tumour suppressor, and has been shown to interact with β-catenin and thus limit Wnt signalling. However, various data also indicate a potential role in regulating the […]
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Yoshiki Sasai: stem cell Sensei

Posted by on August 21st, 2014

This obituary first appeared in Development.   Stefano Piccolo looks back at the life and research of his friend and colleague Yoshiki Sasai.   On 5 August 2014, Yoshiki Sasai died at the age of 52, near to the RIKEN Center for Developmental Biology in Kobe, Japan. This is the institute that he had helped to establish and painstakingly […]
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Accelerated Frogs: Developmental Biology meets Particle Physics

Posted by on August 20th, 2014

I previously wrote a post about the development of a 4-D X-Ray Tomography technique for imaging early Xenopus embryos. Frog embryos are opaque due to their yolky composition and this has proved a challenge for traditional optical microscopy of events in the early stages of Xenopus embryo development. However Julian Moosmann, Ralf Hofmann and Jubin […]
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In Development this week (Vol. 141, Issue 17)

Posted by on August 19th, 2014

Here are the highlights from the current issue of Development:   HSCs make a Runx1 for it The emergence of haematopoietic stem cells (HSCs) during early mammalian development is crucial for the formation of all blood cell lineages. Previous studies indicate that Runx1 is required for the endothelial-haematopoietic transition that gives rise to definitive HSCs; […]
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In Development this week (Vol. 141, Issue 16)

Posted by on August 6th, 2014

Here are the highlights from the current issue of Development:   PCP signalling is dispensable for neural crest migration The neural crest (NC) is a transient and migratory population of cells that gives rise to a variety of cell types. During development, NC cells delaminate from the neural tube in a process that is closely […]
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Challenging an old stem cell dogma

Posted by on August 4th, 2014

Science teachers usually say that science progresses by challenging old dogmas. In the stem cell field, there is a dogma saying that some blood stem cells in the bone marrow stay quiescent (do not divide) for long periods of time. This way, they avoid DNA damage and malignant mutations that could arise during DNA replication […]
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Creative morphometrics – so many tools, so little time

Posted by on August 4th, 2014

Nowadays, the hardest thing in science is similar to what we experience in daily life, that is organization and choice. In a virtual plethora of techniques, methods and analyses, an aspiring researcher is faced with a flood of information, achievements and tools of the trade. Especially so with computers. But if it wasn’t for this […]
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