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The Node is a place to share news about and with the developmental biology community around the world. If this is your first time on the site, check out this introduction to the Node. You can also find out more about us, and sign up to contribute.
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In Development this week (Vol. 141, Issue 9)
Posted by Seema Grewal on April 22nd, 2014
Here are the highlights from the new issue of Development: Hemogenic endothelium flexes some muscle Mesoangioblasts (MABs) are progenitor cells of embryonic derivation with mesodermal potential. They have been successfully used to restore skeletal muscle loss in dystrophic mice, but despite the clinical potential of these cells, their origin and role during development has […]
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Flippase recognition target: orientation matters, so why care?
Posted by Mario Metzler on April 16th, 2014
FRT sites are used often (at least in Drosophila) for inducing deletions or “flipping out” of markers in transgenic constructs. When there are two FRTs sequences in tandem, after inducing flippase the DNA sequence that is between these two sites will be deleted. If two FRT sites are facing each other (or looking away), the […]
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Stone Soup Eyes
Posted by Reed College Dev Neuro on April 16th, 2014
Another installment from the Developmental Neurobiology Students at Reed College. Hope you enjoy! It’s not often that you get to recount the classic tale of Stone Soup when thinking about developmental biology, but that’s exactly what we did when discussing an almost classic 2011 Nature paper from Yoshiki Sasai’s group. In the story, a grumpy […]
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Regenerating the aged thymus
Posted by Caroline Hendry on April 9th, 2014
The latest issue of Development includes a paper by Clare Blackburn and colleagues at the Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, showing that the aged mouse thymus can be regenerated in vivo by the upregulation of a single transcription factor, FOXN1. This work has generated quite a lot of interest in […]
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Identified a new possible target to combat muscle wasting
Posted by IRBBarcelona on April 9th, 2014
The pathological atrophy of skeletal muscle is a serious biomedical problem for which no effective treatment is currently available. Those most affected populations are the elderly diagnosed with sarcopenia and patients with cancer, AIDS, and other infectious diseases that develop cachexia. A study by scientists at the Institute for Research in Biomedicine (IRB), headed by […]
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In Development this week (Vol. 141, Issue 8)
Posted by Seema Grewal on April 8th, 2014
Here are the highlights from the current issue of Development: Spine-tingling new role for Sall4 Wnt, Fgf and retinoic acid signalling play a key role in patterning the posterior neural plate to form the midbrain, hindbrain and spinal cord. Despite intense study of Wnt signalling and neural patterning, only a few target transcription factors […]
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Green Eggs and Serrano Ham
Posted by Mariana Delfino Machín on April 4th, 2014
Scenes from Seville (my pics) and a transgenic embryo (A. Fernandez-Miñan)After over a decade working in Europe, I recently returned to Costa Rica to start a lab at the University of Costa Rica (UCR), in San José. Life in the Tropics has its perks, such as regular sightings of sloths and raccoons from my office […]
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Approaching limb regeneration in an emerging model crustacean
Posted by nkonst on April 1st, 2014
My name is Nikos. I just finished my PhD in the lab of Michalis Averof , starting my thesis at IMBB, in Crete and completing it at IGFL, in Lyon. My project aimed to introduce a new arthropod model to regeneration studies. Its main part was published recently (http://www.sciencemag.org/content/343/6172/788.abstract). In this Node post, I would […]
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Learning to Inject Platynereis Embryos
Posted by Maggie Pruitt on March 31st, 2014
Hello! My name is Maggie Pruitt and I am a postdoc in Dr. Stephan Schneider’s laboratory at Iowa State University. At the beginning of this year, I had the wonderful opportunity to visit Dr. Detlev Arendt’s laboratory at EMBL in Heidelberg, Germany for two weeks. This experience was possible due to a Development Travelling Fellowship […]
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Planarians…the key to regenerative medicine?
Posted by Christele Gonneau on March 31st, 2014
Of all the animal models used in biology, the freshwater planarian flatworm is one of the most fascinating: first because roughly 10% of all planarian cells are stem cells, second because these worms can regenerate from almost any injury. This ability to regenerate entire organs (including their own heads!) makes them very popular for […]
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- Hemogenic endothelium flexes some muscle [IN THIS ISSUE]
- Motor efferent axons lead the way [IN THIS ISSUE]
- On growth and gradients [IN THIS ISSUE]
- Developing concepts of wound healing [IN THIS ISSUE]
- miR-8 enables correct synaptogenesis [IN THIS ISSUE]
- Actomyosin networks and tissue morphogenesis [DEVELOPMENT AT A GLANCE]
- Bioengineering approaches to guide stem cell-based organogenesis [REVIEWS]
- Genomic imprinting in development, growth, behavior and stem cells [REVIEWS]
- CXCR7 prevents excessive CXCL12-mediated downregulation of CXCR4 in migrating cortical interneurons [RESEARCH REPORT]
- miR-8 controls synapse structure by repression of the actin regulator Enabled [RESEARCH ARTICLES]
- A conserved axon type hierarchy governing peripheral nerve assembly [RESEARCH ARTICLES]
- Growth control by a moving morphogen gradient during Drosophila eye development [RESEARCH ARTICLES]
- Arabidopsis UNHINGED encodes a VPS51 homolog and reveals a role for the GARP complex in leaf shape and vein patterning [RESEARCH ARTICLES]
- A Gli silencer is required for robust repression of gremlin in the vertebrate limb bud [RESEARCH ARTICLES]
- Clathrin heavy chain plays multiple roles in polarizing the Drosophila oocyte downstream of Bic-D [RESEARCH ARTICLES]
- High-resolution analysis of gene activity during the Xenopus mid-blastula transition [RESEARCH ARTICLES]
- Semaphorin 5B is a repellent cue for sensory afferents projecting into the developing spinal cord [RESEARCH ARTICLES]
- Cadherin 99C regulates apical expansion and cell rearrangement during epithelial tube elongation [RESEARCH ARTICLES]
- Noonan and LEOPARD syndrome Shp2 variants induce heart displacement defects in zebrafish [RESEARCH ARTICLES]
- sept7b is essential for pronephric function and development of left-right asymmetry in zebrafish embryogenesis [Articles of interest in other COB journals]
- Cadherin switching during the formation and differentiation of the Drosophila mesoderm - implications for epithelial-to-mesenchymal transitions [Articles of interest in other COB journals]
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- Editorial Board
- Foxi transcription factors promote pharyngeal arch development by regulating formation of FGF signaling centers
- Hipk promotes photoreceptor differentiation through the repression of Twin of eyeless and Eyeless expression
- Unc45b is essential for early myofibrillogenesis and costamere formation in zebrafish
- Exocyst-mediated membrane trafficking is required for branch outgrowth in Drosophila tracheal terminal cells
- Ephrin-B2 governs morphogenesis of endolymphatic sac and duct epithelia in the mouse inner ear
- Mesodermal Nkx2.5 is necessary and sufficient for early second heart field development
- Maternal bias and escape from X chromosome imprinting in the midgestation mouse placenta
- Editorial Board
- Do the BEAF insulator proteins regulate genes involved in cell polarity and neoplastic growth?
- Lhx1 is required in Müllerian duct epithelium for uterine development
- A role of the LIN-12/Notch signaling pathway in diversifying the non-striated egg-laying muscles in C. elegans
- Cleavage of the Drosophila screw prodomain is critical for a dynamic BMP morphogen gradient in embryogenesis
- Over-expression of DMRT1 induces the male pathway in embryonic chicken gonads
- CYP26B1 promotes male germ cell differentiation by suppressing STRA8-dependent meiotic and STRA8-independent mitotic pathways
- The atypical Rho GTPase, RhoU, regulates cell-adhesion molecules during cardiac morphogenesis
- Microarray meta-analysis identifies evolutionarily conserved BMP signaling targets in developing long bones
- Cooperative interaction of Etv2 and Gata2 regulates the development of endothelial and hematopoietic lineages
- Editorial Board
- Development and evolution of vertebrate cranial placodes
- Setting appropriate boundaries: Fate, patterning and competence at the neural plate border
- Establishing the pre-placodal region and breaking it into placodes with distinct identities
- Neural crest and placode interaction during the development of the cranial sensory system
- Signaling mechanisms controlling cranial placode neurogenesis and delamination
- Sensational placodes: Neurogenesis in the otic and olfactory systems
- The development of lateral line placodes: Taking a broader view
- The evolutionary history of vertebrate cranial placodes – I: Cell type evolution
- The evolutionary history of vertebrate cranial placodes II. Evolution of ectodermal patterning
- Sulf1 influences the Shh morphogen gradient during the dorsal ventral patterning of the neural tube in Xenopus tropicalis
- Oestrogen receptor-alpha regulates non-canonical Hedgehog-signalling in the mammary gland
- Resident progenitors, not exogenous migratory cells, generate the majority of visceral mesothelium in organogenesis
- Editorial Board
- Impact
- Why you should publish your papers in Developmental Biology
- SDB 2014 Meeting Announcement
- Loss of Hand2 in a population of Periostin lineage cells results in pronounced bradycardia and neonatal death
- Posterior skeletal development and the segmentation clock period are sensitive to Lfng dosage during somitogenesis
- Mammalian Fused is essential for sperm head shaping and periaxonemal structure formation during spermatogenesis
- Epigenetic regulation of oogenesis and germ stem cell maintenance by the Drosophila histone methyltransferase Eggless/dSetDB1
- Sfrp1a and Sfrp5 function as positive regulators of Wnt and BMP signaling during early retinal development
- The bristle patterning genes hairy and extramacrochaetae regulate the development of structures required for flight in Diptera
- Retraction notice to “The human placenta is a hematopoietic organ during the embryonic and fetal periods of development” [Dev. Biol. 327 (2009) 24–33]
- Ecdysone differentially regulates metamorphic timing relative to 20-hydroxyecdysone by antagonizing juvenile Hormone in Drosophila melanogaster
- Tbx18 is essential for normal development of vasculature network and glomerular mesangium in the mammalian kidney
- Peroxisomal membrane channel Pxmp2 in the mammary fat pad is essential for stromal lipid homeostasis and for development of mammary gland epithelium in mice
- Cell signaling during development of Dictyostelium
- Canonical Wnt signaling regulates the proliferative expansion and differentiation of fibrocytes in the murine inner ear
- Distinct requirements for beta-catenin in pancreatic epithelial growth and patterning
- The PAF1 complex is involved in embryonic epidermal morphogenesis in Caenorhabditis elegans
- Neuroblast lineage identification and lineage-specific Hox gene action during postembryonic development of the subesophageal ganglion in the Drosophila central brain
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- Dystrophic muscle environment induces changes in cell plasticity [Perspectives]
- DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos [Reviews]
- The diabetes gene Hhex maintains {delta}-cell differentiation and islet function [Research Communications]
- Coupling 40S ribosome recruitment to modification of a cap-binding initiation factor by eIF3 subunit e [Research Communications]
- HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles [Research Papers]
- miR-99a/100~125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGF{beta} and Wnt signaling [Research Papers]
- ATR checkpoint kinase and CRL1{beta}TRCP collaborate to degrade ASF1a and thus repress genes overlapping with clusters of stalled replication forks [Research Papers]
- Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression [Research Papers]
- Distinct regulatory mechanisms balance DegP proteolysis to maintain cellular fitness during heat stress [Research Papers]
- Root growth is modulated by differential hormonal sensitivity in neighboring cells [Research Papers]
- Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin [Errata]
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