the community site for and by developmental biologists
the community site for and by developmental biologists
Posted by aschmidt on September 21st, 2018
Here, Mylène Lancino and myself will introduce our motivation to investigate and delve deeper into one essential and very peculiar process of Stem Cell Biology: the de novo genesis of hematopoietic stem cells, according to a process referred to as the Endothelial-to-Hematopoietic Transition (the EHT, named initially by Kissa & Herbomel 2010). The work led to[…]
Posted by Sha Wang on September 19th, 2018
Sha Wang, Deborah Gumucio This article shares the story behind our recent Developmental Cell paper. It tells the history of this project and how three-dimensional (3D) observations at the individual cell level transformed our preconceived ideas and brought new insights into cell dynamics in the proliferative intestinal epithelium. Epithelial tubes are present in many[…]
Posted by Svend Dahl-Jensen on September 19th, 2018
Water is a fascinating substance. Its behavior sets a lot of interesting constraints on both how the surface of our world is shaped geologically and how life on said surface has adapted to optimize its use. Biology and geology, while vastly different in scale, share many commonalities that can we can learn from. Our work[…]
Posted by Schattschneider Sylvia on September 5th, 2018
The Developmental Biology Unit seeks to understand the general principles and mechanisms underlying the development of multicellular organisms. Researchers in the unit combine the power of genetic model organisms with quantitative imaging and -omics technologies, synthetic biology, reduced (in vitro) systems and theoretical modelling, to create a cross-cutting approach to modern developmental biology. Research in[…]
Posted by dbsste on August 23rd, 2018
It’s an age-old mystery of the heart: do opposites attract, or will like do better with like? We can now answer this pressing question, at least for Drosophila cardioblasts: cells prefer to ‘swipe right’ on a shared transcriptional profile, but the resulting relationships are stronger if there are some unattractive alternatives around to remind them[…]
Posted by Matthew R Johnson on August 21st, 2018
All life requires energy. For early metazoan development, demand is especially high, as the transition from a single cell to a complex, multicellular organism requires a massive energetic input. In the earliest stages of development, however, an organisms’ inability to feed poses an apparent problem: how is the energy necessary to drive development obtained? In[…]
Posted by Julian Lui on August 9th, 2018
About a decade ago I came to the National Institutes of Health (NIH) to work with my mentor, Jeff Baron, to study childhood growth and to tackle one of the unsolved mysteries in biology – mechanisms for body size determination (1). Years have passed, and we probably still don’t understand what makes an elephant an[…]
Posted by Daniel T. Grimes on August 7th, 2018
https://www.grimes-lab.com Postdoctoral positions are available in the laboratory of Daniel T. Grimes, Institute of Molecular Biology and Department of Biology at the University of Oregon. The laboratory focuses on symmetry in the biological world. We are a new lab opening in January 2019. We want to understand how some features of vertebrate bodies (like limbs and[…]
Posted by Helena Jambor on August 6th, 2018
When reading about co-evolution of prey and predators, I stumbled across a cute new plot type: a half boxplot, half dot plot to show data distributions. Wilson used this plot to simultaneously visualize summaries about their data (center, spread) and the actual data points. This allows us, the audience, to learn a lot about[…]
Posted by Scutoids on August 3rd, 2018
In LM Escudero´s group, we like developmental biology, mathematical biology and computational biology. We try to be imaginative and get inspiration from simple things… such as a toilet paper roll. Using this tool (and some computers), we claim that we have described a novel geometrical shape… You will be wondering… how do you do[…]
