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Project Scientist in Exosome Biology

Posted by on March 27th, 2017

The Department of Neurology at the University of California, Irvine anticipates an opening for an Assistant Project Scientist in the Translational Laboratory and Biorepository (TLaB). This position requires solid background in experimental design and fluency in the use of technology germane to investigations of exosomes, including but not limited to, in vitro and in vivo[…]

Leaving the bar in five steps

Posted by on March 24th, 2017

Introduction Graphs (or charts or plots) are often used for the display and summary of data. They are essential tools for the communication of results in presentations or manuscripts. One particular type of graph, the bar graph, is often used to quantitatively compare (multiple) conditions. The earliest known example of a bar graph, dates from[…]

How a cell becomes a giant: a fluctuation-driven patterning mechanism

Posted by on March 22nd, 2017

Heather M. Meyer1, José Teles2, and Pau Formosa-Jordan2   1 Weill Institute for Cell and Molecular Biology and the graduate field of Genetics, Genomics, and Development, Cornell University, Ithaca, NY, 14853 USA 2 Sainsbury Laboratory, University of Cambridge, Cambridge CB2 1LR, UK   Comment on: Heather M. Meyer*, José Teles*, Pau Formosa-Jordan*, Yassin Refahi, Rita[…]

Using RNA sequencing to understand real-world embryos

Posted by on March 22nd, 2017

Comment on “Novel adverse outcome pathways revealed by chemical genetics in a developing marine fish” eLife 6 (2017) Elin Sørhus, John P Incardona, Tomasz Furmanek, Giles W Goetz, Nathaniel L Scholz, Sonnich Meier, Rolf B Edvardsen, Sissel Jentoft Institute of Marine Research, Norway Northwest Fisheries Science Center, USA University of Oslo, Norway   Crude oil[…]

The people behind the papers #16

Posted by on March 15th, 2017

The use of organoids – which can be defined as artificially grown masses of cells or tissue that resemble organs – in basic and clinical research has snowballed in recent years, providing insight into fundamental developmental processes and disease etiology. Today’s paper comes from the new Special Issue of Development devoted entirely to organoids, and reports the use of human[…]

Choosing Sides: Two steps in establishing the polarisation vector in algal zygotes

Posted by on March 14th, 2017

Comment on “Two-step cell polarization in algal zygotes”, Nature Plants, 3, 16221, (2017). Department of Biology, Ghent University, Krijgslaan 281 S8, 9000 Ghent, Belgium VIB-UGent Center for Plant Systems Biology, Technologiepark 927, B-9052 Ghent, Belgium Department of Plant Biotechnology and Bioinformatics, Ghent University, Technologiepark 927, B-9052 Ghent, Belgium   Complex multicellular life has evolved from[…]

In Development this week (Vol. 144, Issue 6) – SPECIAL ISSUE ON ORGANOIDS

Posted by on March 14th, 2017

The current issue of Development – our Special Issue on Organoids – features a collection of review- and research-based articles focusing on organoids. Here are some of the highlights. Happy reading (and thanks to everyone who contributed)!   Organoids: a Special Issue In her Editorial, Melissa Little provides an overview of the entire contents of the[…]

Organelle Assembly in Vivo: The Love-Hate Relationship of Thermodynamic and Active Processes

Posted by on March 6th, 2017

Comment on ”Independent active and thermodynamic processes govern nucleolus assembly in vivo”, Proceedings of the National Academy of Sciences, 114 (6), 1335-1340, (2017). Hanieh Falahati, Lewis–Sigler Institute for Integrative Genomics, Princeton University. Eric Wieschaus, Howard Hughes Medical Institute, Department of Molecular Biology, Princeton University.   The whole universe is moving toward disorder; this is the[…]

Position for Postdoctoral Research Fellow in Cardiovascular Genetics, Montreal, Quebec, Canada

Posted by on March 5th, 2017

A postdoctoral research fellow position is available in the laboratory of Gregor Andelfinger at the CHU Sainte Justine Research Center, Montréal, Québec, Canada. Our work focuses on the genetic origins of cardiovascular diseases in the young and includes both genomics and functional approaches. In this project, the successful candidate will apply genomic and molecular biology[…]

New signal revealed for birth of blood stem cells in vertebrates

Posted by on March 1st, 2017

Jamie R. Genthe and Wilson K. Clements   When blood goes bad, a replacement is often needed. Each year, thousands of patients in the US receive bone marrow transplants to treat life-threatening diseases like blood cancer. But in some cases, the transplant itself can become deadly. The problem is not necessarily the one most people think[…]