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The Node is a place to share news about and with the developmental biology community around the world. If this is your first time on the site, check out this introduction to the Node. You can also find out more about us, and sign up to contribute.
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In Development this week (Vol. 141, Issue 15)
Posted by Seema Grewal on July 22nd, 2014
Here are the highlights from the current issue of Development: talpid2: a mystery finally solved The chicken talpid2 and talpid3 mutants display a range of developmental phenotypes including craniofacial and limb defects. Although links to the sonic hedgehog (SHH) pathway had been proposed, the molecular nature of these mutations remained unclear for many years. […]
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Your non-model organism is going extinct
Posted by SAW on July 17th, 2014
“There is no such thing as a non-model organism” R. Behringer This bold statement was announced less than a week into our Embryology course and has left a lasting impression on lecturers and students alike. At first it seemed like a sympathetic statement to the extensive and diverse systems us students were arriving from… “yeah, […]
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Goalward-bound: why biological research is like football
Posted by Christele Gonneau on July 3rd, 2014
The 2014 FIFA World Cup has mesmerised football fans all around the world over the past weeks, but besides just the fancy footwork on display, we’ve also seen some amazing athleticism. Many of the matches have taken place under scorching, highly humid conditions! Though this might not be foremost in our minds as marvel at […]
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A key component of cell division comes to light
Posted by IRBBarcelona on June 30th, 2014
Jens Lüders leads the Microtubule Organization laboratory (Photo: Battista/Minocri, IRB Barcelona) ”la Caixa” PhD student Nicolas Lecland is the first author of the study published in Nature Cell Biology (Photo: Battista/Minocri, IRB Barcelona) A breakthrough at IRB Barcelona fills a knowledge gap in understanding how the cell division apparatus, the mitotic spindle, is formed. The […]
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Obituary: Julian Hart Lewis (1946-2014)
Posted by the Node on June 25th, 2014
This obituary first appeared in Development. Paul Martin and David Ish-Horowicz look back on the life and work of their long-time friend and colleague Julian Lewis, who passed away on April 30th 2014. Julian Lewis made unique contributions to several areas of cell, developmental and theoretical biology. He combined a formidable intellect and mathematical training with experimental dexterity […]
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A day in the life of a Platynereis dumerilii lab
Posted by Maggie Pruitt on June 25th, 2014
Hello! I am Maggie Pruitt, a postdoctoral researcher in the Department of Genetics, Development, and Cell Biology at Iowa State University (Ames, Iowa, USA – think middle America or fields upon fields). I work in Dr. Stephan Schneider’s evo-devo laboratory, and my work mostly focuses on studying components of the Wnt/β-catenin signaling pathway during early […]
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On segmentation
Posted by Thomas Butts on June 24th, 2014
‘Increasing knowledge leads to triumphant loss of clarity’ ‘The study of segmentation: that way leads only to madness’ Alfred Romer (1894 – 1973), Director of the Museum of Comparative Zoology and Professor of Biology, Harvard University Some problems in biology excite such interest as to become symptomatic of a field. This is true, I […]
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In Development this week (Vol. 141, Issue 13)
Posted by Seema Grewal on June 24th, 2014
Here are the highlights from the current issue of Development: Eye’s got rhythm In zebrafish, the circadian clock, which is the internal timekeeper that coordinates multiple cellular, physiological and behavioural processes with the external rhythmic environment, begins cycling very early in development. However, the functional relevance for embryonic and larval development of these early […]
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The colon has a safety mechanism that restricts tumour formation
Posted by IRBBarcelona on June 23rd, 2014
When adenomas appear in the colon, the same cells of the tissue produce a molecule that neutralizes its progression. Adenomas, which are highly prevalent in the population, provide the substrate on which carcinomas develop. Barcelona, Monday 23 June 2014.- Colon cancer development starts with the formation of benign tumours called adenomas. It is estimated […]
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Electrifying news for embryologists
Posted by Elsa Mazari and Aitana Perea-Gomez on June 17th, 2014
Electroporation: an efficient technique for embryologists During embryonic development, the specification of different cell types giving rise to the future organs involves a precise spatiotemporal regulation of cell proliferation, migration, and differentiation. Studying these processes requires tools to manipulate gene expression locally in the developing embryo.To this aim, embryologists have widely used the technique of […]
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- talpid2: a mystery finally solved [IN THIS ISSUE]
- Starvation MESses up the egg [IN THIS ISSUE]
- A taste for something new [IN THIS ISSUE]
- Cell heterogeneity and multilineage priming in the kidney [IN THIS ISSUE]
- The POU-er of gene nomenclature [SPOTLIGHT]
- The dynamics of plant plasma membrane proteins: PINs and beyond [REVIEW]
- Retinoic acid controls body axis extension by directly repressing Fgf8 transcription [RESEARCH REPORTS]
- The F-box protein Slmb restricts the activity of aPKC to polarize epithelial cells [RESEARCH REPORTS]
- Slmb antagonises the aPKC/Par-6 complex to control oocyte and epithelial polarity [RESEARCH ARTICLES]
- Induction of ectopic taste buds by SHH reveals the competency and plasticity of adult lingual epithelium [RESEARCH ARTICLES]
- The cellular and molecular etiology of the craniofacial defects in the avian ciliopathic mutant talpid2 [RESEARCH ARTICLES]
- Starvation induces FoxO-dependent mitotic-to-endocycle switch pausing during Drosophila oogenesis [RESEARCH ARTICLES]
- A crucial role for polysialic acid in developmental interneuron migration and the establishment of interneuron densities in the mouse prefrontal cortex [RESEARCH ARTICLES]
- The origin and loss of periodic patterning in the turtle shell [RESEARCH ARTICLES]
- Congenital heart disease protein 5 associates with CASZ1 to maintain myocardial tissue integrity [RESEARCH ARTICLES]
- Hand1 phosphoregulation within the distal arch neural crest is essential for craniofacial morphogenesis [RESEARCH ARTICLES]
- Simultaneous rather than ordered cleavage of two sites within the BMP4 prodomain leads to loss of ligand in mice [RESEARCH ARTICLES]
- Loss of focal adhesions in glia disrupts both glial and photoreceptor axon migration in the Drosophila visual system [RESEARCH ARTICLES]
- Islet is a key determinant of ascidian palp morphogenesis [RESEARCH ARTICLES]
- NF-kB controls axonal regeneration and degeneration through cell-specific balance of RelA and p50 in the adult CNS [Articles of interest in other COB journals]
- The conserved transmembrane proteoglycan Perdido/Kon-tiki is essential for myofibrillogenesis and sarcomeric structure in Drosophila [Articles of interest in other COB journals]
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- Editorial Board
- The basal position of nuclei is one pre-requisite for asymmetric cell divisions in the early mouse embryo
- The fat-like cadherin CDH-4 acts cell-non-autonomously in anterior–posterior neuroblast migration
- Staufen targets coracle mRNA to Drosophila neuromuscular junctions and regulates GluRIIA synaptic accumulation and bouton number
- Multiple tissue-specific requirements for the BMP antagonist Noggin in development of the mammalian craniofacial skeleton
- Nanog co-regulated by Nodal/Smad2 and Oct4 is required for pluripotency in developing mouse epiblast
- Transcriptional regulation of Drosophila gonad formation
- Direct functional consequences of ZRS enhancer mutation combine with secondary long range SHH signalling effects to cause preaxial polydactyly
- Cdc42 is required in a genetically distinct subset of cardiac cells during Drosophila dorsal vessel closure
- Setdb2 controls convergence and extension movements during zebrafish gastrulation by transcriptional regulation of dvr1
- Functional characterization of Prickle2 and BBS7 identify overlapping phenotypes yet distinct mechanisms
- Daughterless homodimer synergizes with Eyeless to induce Atonal expression and retinal neuron differentiation
- SUMV-1 antagonizes the activity of synthetic multivulva genes in Caenorhabditis elegans
- GATA4 and GATA6 regulate intestinal epithelial cytodifferentiation during development
- Migratory neural crest cell αN-catenin impacts chick trigeminal ganglia formation
- Specific pattern of cell cycle during limb fetal myogenesis
- Differential regulation of Gli proteins by Sufu in the lung affects PDGF signaling and myofibroblast development
- Nemo promotes Notch-mediated lateral inhibition downstream of proneural factors
- Elf5 counteracts precocious trophoblast differentiation by maintaining Sox2 and 3 and inhibiting Hand1 expression
- Gtpbp2 is required for BMP signaling and mesoderm patterning in Xenopus embryos
- Hectd1 is required for development of the junctional zone of the placenta
- Integrin-α5β1 is not required for mural cell functions during development of blood vessels but is required for lymphatic-blood vessel separation and lymphovenous valve formation
- miR-203 regulates progenitor cell proliferation during adult zebrafish retina regeneration
- Dynamics of F-actin prefigure the structure of butterfly wing scales
- Germ cells of the centipede Strigamia maritima are specified early in embryonic development
- The expansion of body coloration involves coordinated evolution in cis and trans within the pigmentation regulatory network of Drosophila prostipennis
- Emergence of tissue sensitivity to Hox protein levels underlies the evolution of an adaptive morphological trait
- Long bone development requires a threshold of Hox function
- Enhancer diversity and the control of a simple pattern of Drosophila CNS midline cell expression
- A distant downstream enhancer directs essential expression of Tbx18 in urogenital tissues
- Editorial Board
- Development of the lateral line canal system through a bone remodeling process in zebrafish
- NEDD4L regulates convergent extension movements in Xenopus embryos via Disheveled-mediated non-canonical Wnt signaling
- Protein kinase CK2 both promotes robust proliferation and inhibits the proliferative fate in the C. elegans germ line
- TAF4b promotes mouse primordial follicle assembly and oocyte survival
- Regulation of broad by the Notch pathway affects timing of follicle cell development
- Cited2 is required in trophoblasts for correct placental capillary patterning
- Polyspermy block in jellyfish eggs: Collaborative controls by Ca2+ and MAPK
- The role of Bro1- domain-containing protein Myopic in endosomal trafficking of Wnt/Wingless
- Phosphorylation of CDK2 at threonine 160 regulates meiotic pachytene and diplotene progression in mice
- Transcriptional co-regulation of evolutionarily conserved microRNA/cone opsin gene pairs: Implications for photoreceptor subtype specification
- Corrigendum to “prdm12b Specifies the p1 progenitor domain and reveals a role for V1 interneurons in swim movements” [Dev. Biol. 390 (2014) 247–260]
- Abnormal cerebellar development and Purkinje cell Defects in Lgl1-Pax2 conditional knockout mice
- Specification of the mouse cardiac conduction system in the absence of Endothelin signaling
- Identification of genes driving lineage divergence from single-cell gene expression data in C. elegans
- The dystroglycan: Nestled in an adhesome during embryonic development
- Developmental regulation of glial cell phagocytic function during drosophila embryogenesis
- Editorial Board
- Resident progenitors, not exogenous migratory cells, generate the majority of visceral mesothelium in organogenesis
- A gene expression atlas of early craniofacial development
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- Wnt some lose some: transcriptional governance of stem cells by Wnt/{beta}-catenin signaling [Reviews]
- Organismal proteostasis: role of cell-nonautonomous regulation and transcellular chaperone signaling [Reviews]
- Two waves of de novo methylation during mouse germ cell development [Research Communications]
- TRF2, but not TBP, mediates the transcription of ribosomal protein genes [Research Communications]
- Healing for destruction: tRNA intron degradation in yeast is a two-step cytoplasmic process catalyzed by tRNA ligase Rlg1 and 5'-to-3' exonuclease Xrn1 [Research Communications]
- The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages [Research Papers]
- Lineage of origin in rhabdomyosarcoma informs pharmacological response [Research Papers]
- Angiopoietin 2 regulates the transformation and integrity of lymphatic endothelial cell junctions [Research Papers]
- A cell cycle-regulated Slx4-Dpb11 complex promotes the resolution of DNA repair intermediates linked to stalled replication [Research Papers]
- MicL, a new {sigma}E-dependent sRNA, combats envelope stress by repressing synthesis of Lpp, the major outer membrane lipoprotein [Research Papers]
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- Spatial Regionalization and Heterochrony in the Formation of Adult Pallial Neural Stem Cells
- SAS-6 Assembly Templated by the Lumen of Cartwheel-less Centrioles Precedes Centriole Duplication
- High-Resolution Mapping of Chromatin Packaging in Mouse Embryonic Stem Cells and Sperm
- Uniformity of Nucleosome Preservation Pattern in Mammalian Sperm and Its Connection to Repetitive DNA Elements
- Regulation of Plant Stem Cell Quiescence by a Brassinosteroid Signaling Module
- Multiple Mechanisms Modulate Distinct Cellular Susceptibilities toward Apoptosis in the Developing Eye
- Independent Genomic Control of Neuronal Number across Retinal Cell Types
- Distinct Chemokine Signaling Regulates Integrin Ligand Specificity to Dictate Tissue-Specific Lymphocyte Homing
- Live Free or Die: Cell-Cell Adhesion Regulates Sensitivity to Trail-Induced Apoptosis
- The LC3 Acts Downstream of GABARAP to Degrade Autophagosomes by Interacting with the HOPS Subunit VPS39
- Finding a Common Path: Predicting Gene Function using Inferred Evolutionary Trees
- With NuRD, HDACs Go “Nerdy”
- Paternal Nucleosomes: Are They Retained in Developmental Promoters or Gene Deserts?
- Mitochondria Are Clamped to Vacuoles for Lipid Transport
- A Dynamic Interface between Vacuoles and Mitochondria in Yeast
- Cellular Metabolism Regulates Contact Sites between Vacuoles and Mitochondria
- Autophagosome Biogenesis in Primary Neurons Follows an Ordered and Spatially Regulated Pathway
