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Of Arms and Legs: Shedding light onto developmental gene regulation

Posted by on November 19th, 2018

Written and illustrated by: Bjørt K. Kragesteen, Malte Spielmann, and Guillaume Andrey.   In early development, the forelimb and hindlimb buds of tetrapods are morphologically uniform. However, as limb development proceeds, each individual tissue attains a characteristic morphology that ultimately defines the identity of a forelimb (arm) or a hindlimb (leg). How do undifferentiated limbs[…]

Wire together, remodel together

Posted by on November 15th, 2018

Newborn babies are a symbol of immense potential, as they can grow up to be become virtually anybody, from an astronaut to the president. It is no secret that throughout life, there are critical junctions in which specific events or decisions can direct us on one path or another. Such events occur in our brains;[…]

Sex combs in motion: using computer simulations and mathematical modeling to study the evolution of morphogenesis

Posted by on November 14th, 2018

Juan N. Malagon and Ernest Ho tell the story behind their recent paper in PLOS Computational Biology. In the Larsen lab, we are interested in testing a 50-year old question: How do sex combs rotate in fruit flies? Despite extensive studies of the process using 4D confocal microscopy, there remain many questions about the spatial and[…]

Alan Turing’s patterning system can explain the arrangement of shark scales

Posted by on November 7th, 2018

Understanding how complex biological patterns arise is a long standing and fascinating area of scientific research. The patterning, or spatial arrangement, of vertebrate skin appendages (such as feathers, hair and scales) has enabled diverse adaptations, allowing animals to both survive and thrive in varied and challenging environments. Such adaptations include temperature control of mammalian hair1[…]

Multiple Postdoc and Research Tech positions available in Enteric Neurobiology

Posted by on October 31st, 2018

Multiple funded positions for Post-Doctoral Fellows and Research Technicians are available to study Enteric Neurobiology at Johns Hopkins University. Together, the K-Lab and the Pasricha Lab study developmental and adult neurobiology of the Enteric Nervous System. We are seeking motivated, and innovative candidates with strong academic background who can be good team-players to join our[…]

Frog legs: they’re smarter than they look!

Posted by on October 22nd, 2018

By Sera Moon Busse Studying limb regeneration in model organisms is important for the advancement of regenerative medicine in humans. We set out to study regeneration in the hind limbs of the African Clawed Frog Xenopus laevis – this animal is able to regenerate its hind limbs very early in development, but it loses this[…]

Scaling the Fish: An L.A. Story

Posted by on October 18th, 2018

Jeff Rasmussen tells the story behind his recent paper from the Sagasti Lab in Dev Cell. This project began as an extension of my earlier postdoc work in Alvaro Sagasti’s lab investigating removal of axon debris following skin injuries in the larval zebrafish [1] and led me into scientific territory that I never anticipated. It[…]

Spider segmentation gets its SOX on!

Posted by on October 15th, 2018

There is a vast amount of information known about how some animals pattern their bodies into repeated segments, especially in the fruit-fly Drosophila melanogaster. However, when compared to other arthropods, there are several characteristics that are derived in the fruit fly. It has a very short development time, a syncytium at the blastoderm stage allowing[…]

Post-doctoral position in pancreatic tissue engineering available in the Spagnoli lab.

Posted by on October 12th, 2018

A Postdoctoral position is available in the Spagnoli lab. in the Centre for Stem Cell and Regenerative Medicine at King’s College, London. Our team uses interdisciplinary approaches to study pancreas development and stem cells. The candidate will be part of an exciting EU-funded FET-Open consortium aiming at bioengineering pancreatic tissue. Developing therapies for pancreatic diseases,[…]

Make a difference: the alternative for p-values

Posted by on October 8th, 2018

Calculation and reporting of p-values is common in scientific publications and presentations (Cristea and Ioannidis, 2018). Usually, the p-value is calculated to decide whether two conditions, e.g. control and treatment, are different. Although a p-value can flag differences, it cannot quantify the difference itself (footnote 1). Therefore, p-values fail to answer a very relevant question:[…]