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In Development this week (Vol. 144, Issue 12)

Posted by on June 21st, 2017

Here are the highlights from the current issue of Development:   Btbd7 branches out across multiple organs Dynamic changes in epithelial cell-cell adhesion and motility are crucial for branching morphogenesis – the process by which highly branched epithelial organs, such as the lung and kidney, grow and develop from a simple epithelial bud. Although many[…]

Why do we need to understand the structure of the Enteric Nervous System?

Posted by on June 16th, 2017

Insight into the organizational structure of a growing tissue is imperative for understanding its development and function. Structure can reveal the systematic steps undertaken towards making specific positional and cell fate choices/decisions. A well-defined structure helps to dissect the complexity underlying the networks that form as the tissue develops. It helps to elucidate the foundation[…]

Multiple stem cells, population asymmetry and position-dependent heterogeneity emerge as common features of a niche for Drosophila Follicle Stem Cells and mammalian Intestinal Stem Cells

Posted by on June 16th, 2017

A discussion of “Alternative direct stem cell derivatives defined by stem cell location and graded Wnt signalling,” Nat Cell Biol, 2017. 19(5): p. 433-444.   We have recently revised the model of Follicle Stem Cell (FSC) organization in the Drosophila ovary, showing that there is a much larger population of stem cells than formerly realized, that[…]

How to color a lizard: from developmental biology to physics to mathematics

Posted by on June 7th, 2017

One of the research topics in Michel Milinkovitch’s laboratory ( at the University of Geneva (Switzerland) is to understand how squamates (lizards and snakes) generate such a tremendous variety of colours and colour patterns.     Colours The colour of a lizard’s patch of skin is generally the result of the combination among structural and[…]

In Development this week (Vol. 144, Issue 11)

Posted by on May 30th, 2017

Here are the highlights from the current issue of Development:   Getting MAD in meiosis In meiosis I, homologous chromosomes must pair and form crossovers to ensure appropriate chromosome alignment and segregation. During this process, as in mitosis, the spindle assembly checkpoint (SAC) functions to detect misaligned chromosomes at metaphase. This delays anaphase to enable[…]

The evolution of an axon guidance model: from chemotaxis to haptotaxis

Posted by on May 16th, 2017

The canonical model The publication of Marc Tessier-Lavigne’s seminal Cell papers (1, 2) in 1994 describing the identification of netrin1 (from the Sanskrit word, netr, meaning “one who guides”) was a defining moment in my graduate career. My friends and I talked about those papers for weeks, from the incredible technical feat, the biochemical purification[…]

Our latest research on Hormonal regulation of temporal gene expression in neural stem cells

Posted by on May 16th, 2017 @ elife   (No Ratings Yet) Loading…

In Development this week (Vol. 144, Issue 10)

Posted by on May 16th, 2017

Here are the highlights from the current issue of Development: A new model for lineage segregation Lineage segregation during gastrulation has long been thought to be driven by differential cell adhesion and cortical tension among cells, which would together lead to a differential tissue surface tension (TST) and the spatial segregation of specific cell types.[…]

Biotagging: Behind the scenes (and beyond)

Posted by on May 16th, 2017

“It finally got accepted!”, fol­­lowed by “It’s finally out!” about a month later. I am certain this ‘finally’ feeling about their paper is very familiar to those well-acquainted with the peer review process, and it was no different for our recently published Resource article. The ‘biotagging paper’, as we call it within the Sauka-Spengler lab,[…]

Making of the nerve cord: The story of telling neural progenitors when and where not to divide

Posted by on May 5th, 2017

Comment on “Anterior-Posterior Gradient in Neural Stem and Daughter Cell Proliferation Governed by Spatial and Temporal Hox Control”, Current Biology 27, 1161-1172 (2017). Ignacio Monedero, Behzad Yaghmaeian, Stefan Thor. Department of Clinical and Experimental Medicine, Linkoping University, Sweden.   How cells are generated in proper numbers in order to form specific structures in an organism[…]