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Science in the City of Angels

Posted by on December 1st, 2016

Since the first reported results from Yamanaka et al. in 2006, pluripotent stem cell culture has become an advantageous approach for modeling human disorders and diseases. The directed differentiation of stem cells into particular cell types can also be the basis for powerful in vitro models of early developmental defects in humans. Our lab is[…]

In Development this week (Vol. 143, Issue 23)

Posted by on November 29th, 2016

Here are the highlights from the current issue of Development:   Syndecan 4 lets lymphatic endothelial cells go with the flow Fluid flow is known to play a role in the development and remodelling of both blood and lymphatic vessels. But how is fluid flow sensed and transduced into a response? Here, Michael Simons and[…]

The elusive hematopoietic stem cells of Drosophila.

Posted by on November 22nd, 2016

Drosophila hematopoiesis shows striking resemblance with that of vertebrates, both at the level of signalling molecules and the phase of development. Even though there has been no report of Hematopoietic stem cells (HSCs) in Drosophila, this model has been employed extensively to understand progenitor biology and niche interactions. The Drosophila blood cells are specialised precursor[…]

How to build and evolve a nervous system

Posted by on November 20th, 2016

Author Summary of “A gene regulatory network for apical organ neurogenesis and its spatial control in sea star embryos”.   Alys M. Cheatle Jarvela, Kristen A. Yankura, Veronica F. Hinman Development 2016 143: 4214-4223; doi: 10.1242/dev.134999 Very similar cell types are found across the animal tree of life. Much of animal diversity, therefore, arises not from the formation of new cells, but[…]

Paris – Cambridge – Paris: a Megakaryocyte story

Posted by on November 14th, 2016

The first news came as a shock: so the British Railways are not always perfectly on time? For an Italian, that was a massive cultural shock. The second one was even more surprising: English weather is not that bad; actually, it is better than Parisian weather. But still, I was unable, on the train from Paris to Cambridge, to stop thinking about how[…]

Forgotten classics: Rosa Beddington’s chimeras

Posted by on November 11th, 2016

R. S. P. Beddington (1981). An autoradiographic analysis of the potency of embryonic ectoderm in the 8th day postimplantation mouse embryo. Journal of Experimental Embryology and Morphology. 64: 87-10. Open Access R. S. P. Beddington (1982). An autoradiographic analysis of tissue potency in different regions of the embryonic ectoderm during gastrulation in the mouse. Journal of Experimental[…]

A Day in the Life of a Coral Lab

Posted by on November 8th, 2016

Hi, I’m Yuuri Yasuoka, a postdoc in the Marine Genomics Unit at the Okinawa Institute of Science and Technology Graduate University (OIST). Okinawa is a subtropical Japanese island surrounded by beautiful coral reefs (Figure 1). Why do we study coral here? OIST is the best place in Japan to study coral, with the good access[…]

From biology to art

Posted by on November 4th, 2016

At the BSDB’s  Autumn Meeting on chimeras, scientist and artist Mia Buehr exhibited some of her art inspired by developmental biology. Here, she introduces her pieces. You can keep up with her work at theaccidentalembroiderer.typepad.com   I was born into a family of artists, and painting and drawing were always second nature to me. However I[…]

In Development this week (Vol. 143, Issue 21)

Posted by on November 1st, 2016

Here are the highlights from the current issue of Development:   Signalling cross-talk in the plant root In plants, root architecture is responsive to environmental changes. The plant hormones cytokinin, auxin and ethylene are known to regulate root growth: cytokinin signalling, acting via type-B ARR effectors, inhibits both proliferation and elongation of root cells, while[…]

Post-doctoral position in Skeletal Evo-Devo: Canada

Posted by on October 28th, 2016

A post-doctoral position is available in the Franz-Odendaal Bone Development Lab to study the developmental basis of the vertebrate ocular skeleton in a comparative context. Highly motivated and independent individuals with excellent interpersonal skills are encouraged to apply. The successful applicant will take a key role in our research program which spans evo-devo, developmental genetics[…]