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The Node is a place to share news about and with the developmental biology community around the world. If this is your first time on the site, check out this introduction to the Node. You can also find out more about us, and sign up to contribute.
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In Development this week (Vol. 142, Issue 5)
Posted by Seema Grewal on February 24th, 2015
Here are the highlights from the current issue of Development: pancRNAs in early development Promoter-associated noncoding RNAs (pancRNAs) are a class of long noncoding RNAs, transcribed from bidirectional promoters and thought to be involved in promoting expression of the gene transcribed from the opposite strand. Takuya Imamura and colleagues (p.910) now set out to […]
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How to eradicate an organ
Posted by Manuel Stemmer on February 11th, 2015
Phreatichthys andruzzii, lateral view (left), frontal view (right) Adaptations of some fish species to their environment can be most peculiar, especially within cave dwelling kinds. The so called troglomorphisms slowly turn these fish into almost grotesque looking creatures with no eyes, lost pigments and no scales on the one hand, but with enhanced alternative sensory […]
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In Development this week (Vol. 142, Issue 4)
Posted by Seema Grewal on February 10th, 2015
Here are the highlights from the current issue of Development: Pathways to human hypothalamic neurons The dysfunction of hypothalamic neurons is implicated in a number of common diseases, including obesity, hypertension, and mood and sleep disorders. To date, studies of human hypothalamic neurons have been limited due to their inaccessibility, but now (on p. […]
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Specifying stem cells, specifically
Posted by WIMMBlogEditor on February 5th, 2015
Bone marrow transplants save lives. It’s as simple as that. The reason bone marrow transplants are so effective is because this squishy tissue is home to haematopoietic stem cells (HSCs), which spend their lives happily producing every single blood cell that will ever circulate around your body. As a result, if anything goes wrong with […]
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BSDB Gurdon Summer Studentship Report (3)
Posted by BritSocDevBiol (BSDB) on February 3rd, 2015
In 2014, the British Society of Developmental Biology (BSDB) has initiated the Gurdon Summer Studentship program with the intention to provide highly motivated students with exceptional qualities and a strong interest in Developmental Biology an opportunity to engage in practical research. The 10 successful applicants spent 8 weeks in the research laboratories of their choices, […]
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Stem cells…now showing in 3D
Posted by Christele Gonneau on January 22nd, 2015
Growing organs in vitro is one of the ultimate dreams of any stem cell biologist. As such, it seems obvious that some of these organs will need to be grown in 3D. This is why stem cell 3D culture systems are very fashionable among scientists. They are increasingly successful and a fair amount […]
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In Development this week (Vol. 142, Issue 3)
Posted by Seema Grewal on January 20th, 2015
Here are the highlights from the new issue of Development: Invadosomes: aiding axonal invasion Invasive cells such as immune and metastatic cancer cells form protrusions known as invadosomes, which mediate adhesion to the underlying substrate and induce extracellular matrix degradation – thus promoting invasiveness. On p. 486, Timothy Gomez and colleagues demonstrate that invadosomes […]
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In Development this week (Vol. 142, Issue 2)
Posted by Seema Grewal on January 6th, 2015
Here are the highlights from the new issue of Development: The ‘second brain’: taking gut development up a Notch The vertebrate gastro-intestinal (GI) tract consists of a regionalized epithelial tube surrounded by mesenchyme that later differentiates into smooth muscle. During the early stages of stomach patterning in chick embryos, the primitive GI track is […]
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The rabbit blastocyst modelling (for) vertebrate gastrulation
Posted by Christoph Viebahn on January 5th, 2015
Form and function of animal gastrulation have been longstanding classics accompanying the rise of experimental embryology, and – as if to square the circle in the literal sense – the blastopore of Haeckel’s original ‘gastrea’ stage[1] was soon (and still is) considered analogous to the straight primitive streak of birds and mammals[2-4]. Both forms are […]
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Of mice and men: exploring Mouse ENCODE
Posted by RebeccaL on December 17th, 2014
The Mouse ENCODE Project released a slew of papers late last month reporting findings from a three-year effort to comprehensively map functional elements in the mouse genome. Their major findings are summarized in an integrative paper in Nature (Yue, F. et. al., 2014). Similar to the goals of the human ENCODE project (The ENCODE Project Consortium, […]
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- pancRNAs in early development [IN THIS ISSUE]
- Uncovering neurogenic potential of striatal astrocytes [IN THIS ISSUE]
- Timing degradation to tune development [IN THIS ISSUE]
- Getting to the heart of heart cell identity [IN THIS ISSUE]
- Asymmetric division and fate in the retina [IN THIS ISSUE]
- Neural development and regeneration: it's all in your spinal cord [MEETING REVIEW]
- A pathway to bone: signaling molecules and transcription factors involved in chondrocyte development and maturation [REVIEW]
- Auxin-induced degradation dynamics set the pace for lateral root development [RESEARCH REPORT]
- Gene activation-associated long noncoding RNAs function in mouse preimplantation development [RESEARCH ARTICLES]
- A MEIG1/PACRG complex in the manchette is essential for building the sperm flagella [RESEARCH ARTICLES]
- Contributions of Costal 2-Fused interactions to Hedgehog signaling in Drosophila [RESEARCH ARTICLES]
- Late Alk4/5/7 signaling is required for anterior skeletal patterning in sea urchin embryos [RESEARCH ARTICLES]
- Geometric control of ciliated band regulatory states in the sea urchin embryo [RESEARCH ARTICLES]
- The cytoplasmic domain of the gamete membrane fusion protein HAP2 targets the protein to the fusion site in Chlamydomonas and regulates the fusion reaction [RESEARCH ARTICLES]
- Wnt ligands from the embryonic surface ectoderm regulate 'bimetallic strip' optic cup morphogenesis in mouse [RESEARCH ARTICLES]
- Muscle composition is regulated by a Lox-TGF{beta} feedback loop [RESEARCH ARTICLES]
- Drosophila small heat shock protein CryAB ensures structural integrity of developing muscles, and proper muscle and heart performance [RESEARCH ARTICLES]
- Extramacrochaetae functions in dorsal-ventral patterning of Drosophila imaginal discs [RESEARCH ARTICLES]
- Cell competition in mouse NIH3T3 embryonic fibroblasts is controlled by the activity of Tead family proteins and Myc [Articles of interest in other COB journals]
- miR-145 suppresses embryo-epithelial juxtacrine communication at implantation by modulating maternal IGF1R [Articles of interest in other COB journals]
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- Editorial Board
- Letter from the editor – issue 399/1–1 March 2015
- Loss of Npn1 from motor neurons causes postnatal deficits independent from Sema3A signaling
- Asymmetric expression of connexins between luminal epithelial- and myoepithelial- cells is essential for contractile function of the mammary gland
- A dual epimorphic and compensatory mode of heart regeneration in zebrafish
- p120 Catenin is required for normal tubulogenesis but not epithelial integrity in developing mouse pancreas
- Mice lacking the transcription factor SHOX2 display impaired cerebellar development and deficits in motor coordination
- Motor neuron cell bodies are actively positioned by Slit/Robo repulsion and Netrin/DCC attraction
- A diffusible signal derived from hematopoietic cells supports the survival and proliferation of regenerative cells during zebrafish fin fold regeneration
- Differential regenerative capacity of neonatal mouse hearts after cryoinjury
- Nephron proximal tubule patterning and corpuscles of Stannius formation are regulated by the sim1a transcription factor and retinoic acid in zebrafish
- Tie1 is required for lymphatic valve and collecting vessel development
- A requirement for Gch1 and tetrahydrobiopterin in embryonic development
- Sox4 regulates choroid fissure closure by limiting Hedgehog signaling during ocular morphogenesis
- The boule gene is essential for spermatogenesis of haploid insect male
- The requirement of histone modification by PRDM12 and Kdm4a for the development of pre-placodal ectoderm and neural crest in Xenopus
- The cochlear sensory epithelium derives from Wnt responsive cells in the dorsomedial otic cup
- A 190 base pair, TGF-β responsive tooth and fin enhancer is required for stickleback Bmp6 expression
- A genetic interactome of the let-7 microRNA in C. elegans
- Mesenchymal Wnt signaling Promotes formation of sternum and thoracic body wall
- Xenopus pax6 mutants affect eye development and other organ systems, and have phenotypic similarities to human aniridia patients
- Cre recombinase-regulated Endothelin1 transgenic mouse lines: Novel tools for analysis of embryonic and adult disorders
- IFT46 plays an essential role in cilia development
- Integration of comprehensive 3D microCT and signaling analysis reveals differential regulatory mechanisms of craniofacial bone development
- BMP signaling mediated by constitutively active Activin type 1 receptor (ACVR1) results in ectopic bone formation localized to distal extremity joints
- The myogenic repressor gene Holes in muscles is a direct transcriptional target of Twist and Tinman in the Drosophila embryonic mesoderm
- BMP-dependent gene repression cascade in Drosophila eggshell patterning
- Bark beetle controls epithelial morphogenesis by septate junction maturation in Drosophila
- An oncologist׳s friend: How Xenopus contributes to cancer research
- Editorial Board
- From classical to current: Analyzing peripheral nervous system and spinal cord lineage and fate
- Maternal-zygotic knockout reveals a critical role of Cdx2 in the morula to blastocyst transition
- Comprehensive single cell-resolution analysis of the role of chromatin regulators in early C. elegans embryogenesis
- Ecdysone regulates morphogenesis and function of malpighian tubules in Drosophila melanogaster through EcR-B2 isoform
- Mapping the dynamic expression of Wnt11 and the lineage contribution of Wnt11-expressing cells during early mouse development
- Effects of polysialic acid on sensory innervation of the cornea
- Somatic insulin signaling regulates a germline starvation response in Drosophila egg chambers
- Heixuedian (heix), a potential melanotic tumor suppressor gene, exhibits specific spatial and temporal expression pattern during drosophila hematopoiesis
- Tak1, Smad4 and Trim33 redundantly mediate TGF-β3 signaling during palate development
- Foxp1/2/4 regulate endochondral ossification as a suppresser complex
- C. elegans NIMA-related kinases NEKL-2 and NEKL-3 are required for the completion of molting
- E3 ubiquitin ligases promote progression of differentiation during C. elegans embryogenesis
- Ascl1 and Helt act combinatorially to specify thalamic neuronal identity by repressing Dlxs activation
- DMRT1 is required for Müllerian duct formation in the chicken embryo
- Region-specific regulation of cell proliferation by FGF receptor signaling during the Wolffian duct development
- Lineage and stage specific requirement for Dicer1 in sympathetic ganglia and adrenal medulla formation and maintenance
- Evolutionary variations in the expression of dorso-ventral patterning genes and the conservation of pioneer neurons in Tribolium castaneum
- Editorial Board
- Differential pleiotropy and HOX functional organization
- A method for using direct injection of plasmid DNA to study cis-regulatory element activity in F0 Xenopus embryos and tadpoles
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- Nuclear pore proteins and the control of genome functions [Reviews]
- The Ino80 complex prevents invasion of euchromatin into silent chromatin [Research Communications]
- Cas9 function and host genome sampling in Type II-A CRISPR-Cas adaptation [Research Communications]
- Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF [Research Papers]
- Recognition of H3K9 methylation by GLP is required for efficient establishment of H3K9 methylation, rapid target gene repression, and mouse viability [Research Papers]
- A dual cis-regulatory code links IRF8 to constitutive and inducible gene expression in macrophages [Research Papers]
- The E-Id protein axis modulates the activities of the PI3K-AKT-mTORC1-Hif1a and c-myc/p19Arf pathways to suppress innate variant TFH cell development, thymocyte expansion, and lymphomagenesis [Research Papers]
- A high-sensitivity phospho-switch triggered by Cdk1 governs chromosome morphogenesis during cell division [Research Papers]
- Structural basis for corepressor assembly by the orphan nuclear receptor TLX [Research Papers]
- Structures of regulatory machinery reveal novel molecular mechanisms controlling B. subtilis nitrogen homeostasis [Research Papers]
- In vivo investigation of the transcription, processing, endonucleolytic activity, and functional relevance of the spatial distribution of a plant miRNA [Errata]
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- TSC1 Activates TGF-β-Smad2/3 Signaling in Growth Arrest and Epithelial-to-Mesenchymal Transition
- CENP-A K124 Ubiquitylation Is Required for CENP-A Deposition at the Centromere
- SCML2 Establishes the Male Germline Epigenome through Regulation of Histone H2A Ubiquitination
- Ect2/Pbl Acts via Rho and Polarity Proteins to Direct the Assembly of an Isotropic Actomyosin Cortex upon Mitotic Entry
- Mechanical Tension Drives Cell Membrane Fusion
- Nodal Signaling Range Is Regulated by Proprotein Convertase-Mediated Maturation
- Weaning Triggers a Maturation Step of Pancreatic β Cells
- A Dicer-miR-107 Interaction Regulates Biogenesis of Specific miRNAs Crucial for Neurogenesis
- Puzzling Out Neurodevelopment
- The Evolution of Early Neurogenesis
- Neuronal Aggregates: Formation, Clearance, and Spreading
- Genetic Changes Shaping the Human Brain
- Cellular Functions of the Amyloid Precursor Protein from Development to Dementia
- Programmed Cell Death in Neurodevelopment
- Microglia: Multitasking Specialists of the Brain
- Subcellular Patterning: Axonal Domains with Specialized Structure and Function
- Dynamics and Mechanisms of CNS Myelination
- It Takes a Village: Constructing the Neurogenic Niche
- Evolution of Patterning Systems and Circuit Elements for Locomotion
- Neuronal Regeneration from Ependymo-Radial Glial Cells: Cook, Little Pot, Cook!
