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The blastocyst achieves on-time implantation by entosis

Posted by on September 1st, 2015

The process of embryo implantation consists of multiple steps: blastocyst apposition, adhesion to uterine luminal epithelial (LE) cells, and removal of the epithelial cells encasing the blastocysts. How the blastocyst trophectoderm breaches the luminal epithelial barrier has been studied for decades, the mechanism of the abstraction of LE cells was not clearly understood. Since the[…]

In Development this week (Vol. 142, Issue 17)

Posted by on September 1st, 2015

Here are the highlights from the current issue of Development:   Tubulogenesis at single-cell resolution Formation of the blood vessels involves complex endothelial morphogenesis, including directional cell migration and lumen formation. Understanding the cell biological processes underlying vessel formation in vivo requires the ability to analyse the behaviour of single cells at high spatiotemporal resolution[…]

Tumour suppressor genes curb growth in neighbouring cells

Posted by on August 28th, 2015

The healthy development of an organism depends on its tissues and organs growing to the right size, stopping when they need to, and maintaining stability in their form and function. Correct development depends on the availability of nutrients to the cells in their environment, a process that is tightly controlled by signalling mechanisms that occur[…]

From our sister journals- August 2015

Posted by on August 24th, 2015

Here is some developmental biology related content from other journals published by The Company of Biologists.         Deducing the stage of origin of Wilms tumours from a developmental series of Wt1 mutants Wilms’ tumours, paediatric kidney cancers, are the archetypal example of tumours caused through the disruption of normal development. In this[…]

Key protein in cilia assembly identified

Posted by on August 21st, 2015

The group led by ICREA Research Professor Cayetano Gonzalez at IRB Barcelona, in collaboration with the group of Professor Giuliano Callaini from the University of Siena in Italy, has published a new study in Current Biology that contributes to understanding how cilia are assembled. Many cells in our bodies present a small structure that looks[…]

In Development this week (Vol. 142, Issue 16)

Posted by on August 18th, 2015

Here are the highlights from the current issue of Development:   Probing gene expression dynamics in stem cells The accurate control of gene expression is essential for cell differentiation during development but how do heterogeneous and fluctuating gene expression levels influence cell fate choices? Here (p. 2840), using a novel quantitative and high-content imaging platform,[…]

The protein that keeps cells static is found to play a key role in cell movement

Posted by on August 14th, 2015

The protein E-Cadherin (E-Cad) is a kind of adhesive that keeps cells tightly bound together, thus favouring the organisation of tissues and organs. Scientists at the Institute for Research in Biomedicine (IRB Barcelona) now reveal a new function for E-Cad, one that contrasts with its accepted role in impeding cell movement. The researchers have published[…]

Gap junctions: versatile mediators of long-range developmental signals

Posted by on August 13th, 2015

My lab works on developmental bioelectricity, studying how cells communicate via endogenous gradients of plasma membrane resting potential (Vmem) in order to coordinate their activity during pattern regulation (Levin, 2013; Levin, 2014b; Tseng and Levin, 2013). It is well-known that resting potential is an important regulatory parameter for individual cells’ proliferation, differentiation, and oncogenic potential[…]

In Development this week (Vol. 142, Issue 15)

Posted by on August 4th, 2015

Here are the highlights from the current issue of Development:   CHD4 restrains gene expression during lineage specification The first lineage-specification event in the early embryo generates the inner cell mass (ICM), which later gives rise to the embryo proper, and the trophectoderm (TE), which then develops into extra-embryonic tissues. This fate decision is known[…]

From our sister journals- July 2015

Posted by on July 28th, 2015

Here is some developmental biology related content from other journals published by The Company of Biologists.         Drosophila helps to elucidate the effects of radiation therapy Children who are exposed to cranial radiation therapy (CRT) to treat brain tumours are at increased risk later in life for neurocognitive, motor and seizure disorders.[…]