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A fine balance: tuning adult neurogenesis in the freshwater planarian

Posted by on January 12th, 2017

Comment on “Neuronal sources of hedgehog modulate neurogenesis in the adult planarian brain”, eLife 2016;5:e19735. Currie et al., eLife (2016)   Ko W. Currie, Cellular Neurobiology, Institut de recherches cliniques de Montreal (IRCM), Montreal, QC Alyssa M. Molinaro, Hospital for Sick Children, Toronto, ON Bret J. Pearson, Hospital for Sick Children, Toronto, ON   To say[…]

The fly reveals a new signal involved in limb growth

Posted by on January 9th, 2017

Researchers at IRB Barcelona identify a fundamental role of the JAK/STAT signalling pathway in the development and growth regulation of limbs in Drosophila. Published in Nature Communications, the study paves the way to research into the function of this pathway in vertebrate development and its possible involvement in human congenital diseases.   Many of the[…]

The home of the implanting embryo: A 3D perspective

Posted by on January 5th, 2017

Comment on “Insights from imaging the implanting embryo and the uterine environment in three dimensions”, Arora et al, Development 143(24):4749-4754 (2016).   More than 2000 years ago, Hippocrates (460-377BC) and Aristotle (384-322BC) described the human uterus as a series of chambers with a lining of tentacles or suckers. They believed that blood vessels connected the breast[…]

In Development this week (Vol. 144, Issue 1)

Posted by on January 3rd, 2017

Here are the highlights from the new issue of Development – the first one of the year. Happy reading…and Happy New Year!   Embryos rewired: the changing metabolome of early embryogenesis During early mammalian embryogenesis, the developing embryo must adapt to changing metabolic demands and substrate availability. It has long been thought that a metabolic[…]

Dynamic new roles for local RNA regulation in neural stem cells of the developing brain

Posted by on December 22nd, 2016

Debby Silver and Louis-Jan Pilaz Comment on Pilaz, at al. Current Biology. 26(24): 3383-3392   Neurons and glia of the developing brain are produced from an elegant cell cell type called radial glia. These stem cells are fascinating not only because of their inherent multipotent nature, but also because of their unique bipolar morphology. Radial glia are[…]

Postdoctoral Fellows (Two positions) in RNA Neurobiology at the Alonso Lab

Posted by on December 21st, 2016

Postdoctoral Fellows (Two positions) RNA Control of Neural Development and Behaviour Alonso Lab, University of Sussex Brighton, United Kingdom Two postdoctoral positions are available in the School of Life Sciences at the University of Sussex supervised by Professor Claudio Alonso (http://www.sussex.ac.uk/lifesci/alonsolab/) within the broad field of Molecular and Developmental Neuroscience. The aim of the project[…]

LabCIRS – Learning from mistakes

Posted by on December 13th, 2016

Biomedical research is experiencing what has been termed a ‘reproducibility crisis’. There is much talk about how we can improve the rigor and robustness of our research to increase its value and predictiveness. Many remedies are being discussed, such as increasing statistical power, reducing bias by improving internal validity, fostering transparency by open data policies,[…]

In Development this week (Vol. 143, Issue 24)

Posted by on December 13th, 2016

Here are the highlights from the new issue of Development…the last one of the year!   SETting chromatin state through transcription Setd5 is a poorly characterised murine member of the SET domain family, generally associated with histone methyltransferase activity. However, the closest homologues of Setd5 are thought to be catalytically inactive, and have instead been[…]

Science in the City of Angels

Posted by on December 1st, 2016

Since the first reported results from Yamanaka et al. in 2006, pluripotent stem cell culture has become an advantageous approach for modeling human disorders and diseases. The directed differentiation of stem cells into particular cell types can also be the basis for powerful in vitro models of early developmental defects in humans. Our lab is[…]

In Development this week (Vol. 143, Issue 23)

Posted by on November 29th, 2016

Here are the highlights from the current issue of Development:   Syndecan 4 lets lymphatic endothelial cells go with the flow Fluid flow is known to play a role in the development and remodelling of both blood and lymphatic vessels. But how is fluid flow sensed and transduced into a response? Here, Michael Simons and[…]