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Sensing and making sense of clonal fragmentation in developing tissues

Posted by on March 23rd, 2018

Steffen Rulands and Benjamin Simons A discussion of our recent paper: Rulands S et al., Universality of clone dynamics during tissue development. Nature Physics | doi:10.1038/s41567-018-0055-6   Often, the most enjoyable research projects are the ones that were never planned; and so it was with the current study.   In developmental biology, genetic lineage tracing[…]

Mechanical cues as developmental pacers that orchestrate morphogenesis

Posted by on March 22nd, 2018

In these lines I share with you some details of our recently published Nature paper. I will comment how this project was started and details which are not included in the manuscript. Finally, I will briefly comment on some questions we are working on today and others we believe are worth addressing in the future.[…]

Postdoctoral Fellow Positions in Development and Regenerative Medicine at the University of California, San Francisco (UCSF)

Posted by on March 20th, 2018

Two Postdoctoral positions are immediately available at the University of California, San Francisco (UCSF), in the laboratory of Sarah Knox. Position 1: The applicant will be part of an NIH-funded investigation into the development, regeneration and aging of exocrine organs including salivary glands, pancreas and ocular organs. The project specifically focuses on nerve-stem cell communication and[…]

When the obvious fails, look at the unexpected: interneuron individual behavior affects the population migration.

Posted by on March 19th, 2018

The story behind our paper: Cell-Intrinsic Control of Interneuron Migration Drives Cortical Morphogenesis. Carla G. Silva, Elise Peyre, Mohit H. Adhikari, Sylvia Tielens, Sebastian Tanco, Petra Van Damme, Lorenza Magno, Nathalie Krusy, Gulistan Agirman, Maria M. Magiera, Nicoletta Kessaris, Brigitte Malgrange, Annie Andrieux, Carsten Janke, Laurent Nguyen   The research behind this article is a[…]

In vivo profiling of chromatin accessibility with CATaDa

Posted by on March 13th, 2018

The following post is an introduction into the technnique described in our recent paper: Aughey, G.N., et al., CATaDa reveals global remodelling of chromatin accessibility during stem cell differentiation in vivo. Elife, 2018. 7.   Attempting to understand the biology of a complex organ, like the brain, comes with an array of technical challenges. Those[…]

The Curious Case of Protocadherin 19 Epilepsy

Posted by on March 12th, 2018

Daniel Pederick & Paul Thomas Comment on our paper: Pederick, et al. 2018. Abnormal Cell Sorting Underlies the Unique X-Linked Inheritance of PCDH19 Epilepsy. Neuron 97 (1).   Here we discuss the curious case of female-restricted epilepsy, an unusual disorder caused by mutations in the Protocadherin 19 (PCDH19) gene. How changes in this cell adhesion[…]

Team work, good science

Posted by on March 8th, 2018

You can find our recently published eLife paper here.   At the Euro-Evo-Devo meeting in Lisbao I saw a talk by Sylvie Rétaux and became hooked by a blind and unpigmented cavefish: the evo-devo model Astyanax mexicanus. I then had the chance to join Sylvie’s group in Gif-sur-Yvette (France) in 2013, for a post-doc. Four[…]

Stem cell fate choice: determined in an instant

Posted by on March 6th, 2018

Jun Chen National Institute of Biological Sciences, Beijing A discussion of our recent paper: Chen J, Xu N, Wang C, Huang P, Huang H, Jin Z, Yu Z, Cai T, Jiao R, Xi R. Transient Scute activation via a self-stimulatory loop directs enteroendocrine cell pair specification from self-renewing intestinal stem cells. Nat Cell Biol. 2018[…]

Conformation of the insulin receptor

Posted by on March 5th, 2018

A few days back over dinner at a CNV gathering, Theresia Gutmann from the Coskun lab casually told me about her PhD work. In collaboration with the Rockefeller University NYC, Theresia had visualized the changing conformation of the human insulin receptor upon insulin binding (paper). I made a sketchnote summarizing their discovery of a conformational[…]

Understanding cell- and tissue-level decision-making – a tense and crowded situation in the skin!

Posted by on February 23rd, 2018

The story behind our paper: Yekaterina A. Miroshnikova*, Huy Q. Le*, David Schneider*, Torsten Thalheim, Matthias Rübsam, Nadine Bremicker, Julien Polleux, Nadine Kamprad, Marco Tarantola, Irène Wang, Martial Balland, Carien M. Niessen, Joerg Galle & Sara A. Wickström. Adhesion forces and cortical tension couple cell proliferation and differentiation to drive epidermal stratification. Nature Cell Biology 20, p69–80[…]