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“Smells Like Development” – The 73rd Society for Developmental Biology Meeting

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Towards a synthetic embryo

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Outreach Program: “Ciencia Al Tiro” (Science Immediately)

In Development this week (Vol. 141, Issue 21)

Posted by on October 21st, 2014

Here are the highlights from the new issue of Development:   Two top tips for angiogenesis The widely accepted model of angiogenic sprouting proposes that a single cell – the tip cell – is found at the leading edge of vessel sprouts. Now, Victoria Bautch and colleagues describe an alternative blood vessel topology in which […]
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Full-term development of quail chick by ICSI

Posted by on October 18th, 2014

The eggs of domestic birds have been used in the study of developmental biology, leading to the extensive accumulation of knowledge on embryonic development. However, the early events involved in bird development, particularly the mechanism underlying fertilization, have not been elucidated in as much detail as those of other species of animals. The ooplasm in […]
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Flies with colon cancer help to unravel the genetic keys to disease in humans

Posted by on October 8th, 2014

Researchers generate for the first time Drosophila melanogaster with intestinal cancer and reveal key genetic factors behind human colon cancer. The scientists identify a human gene that favours the proliferation of tumour cells in early stages of colon cancer. Furthermore, the flies are useful for faster and more economic drug screening. Researchers at the Institute […]
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Crossing fields- EMBO conference on interdisciplinary plant development

Posted by on October 8th, 2014

There is something exciting about biologists joining forces with physicists and/or mathematicians, and finding a common language to solve biological problems that are just too complex to understand without stepping outside the realm of ‘traditional’ biology. At the recent EMBO conference on plant development, interdisciplinary studies were the main focus. And as the organiser of […]
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In Development this week (Vol. 141, Issue 20)

Posted by on October 7th, 2014

Here are the highlights from the current issue of Development:   Small (molecule) steps to making bone The repair of cartilage and bone following damage remains a clinical challenge. Current cell-based therapies rely mostly on adult mesenchymal stromal cells, but the expansion of these into correctly differentiated and functionally competent chondrocytes, which give rise to […]
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Tough decisions for the developing brain

Posted by on October 3rd, 2014

To form complex organs, somatic stem cells proliferate and then differentiate during development. In this process, intrinsic factors, i.e. the sequential expression of transcriptional genes, and extrinsic factors, i.e. extracellular microenvironment, are intimately involved. Recent in vitro studies have revealed that the physical properties of the extracellular niche, possibly tissue stiffness, may play an important […]
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What do sperm have to do with brain tumors?

Posted by on October 2nd, 2014

  This post was originally published in the Knoepfler Lab Stem Cell Blog.      Sometimes in science there are unexpected threads tying seemingly very different things together. Unraveling the knots in these threads can lead to new insights into important developmental processes and mechanisms of disease. My lab studies epigenomic and transcription factors including […]
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Towards a synthetic embryo

Posted by on September 24th, 2014

Waddington, whose writings on the epigenetic landscape continue to influence developmental biology to this day, called the developing embryo “the most intriguing object that nature has to offer”(Waddington, 1966). The mechanisms of pattern formation and morphogenesis have fascinated biologists for centuries. One question that is difficult to answer is what are the minimal requirements for […]
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When real life becomes equations: Control of Epiblast and Primitive Endoderm specification during mouse preimplantation development.

Posted by on September 23rd, 2014

During mouse preimplantation development, the zygote divides and forms three distinct lineages: one embryonic called the Epiblast (Epi) and two extraembryonic called trophectoderm (TE) and Primitive Endoderm (PrE). The first cell fate decision occurs at the morula stage (from 16-cell to 32-cell) between TE and the Inner Cell Mass (ICM) and the second cell fate […]
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The origin of blood

Posted by on September 4th, 2014

As for the origin of species, the question of the origin of blood during development has unleashed a lot of passion among the scientific community. As a matter of fact, the failure to derive blood stem cells (haematopoietic stem cells, HSCs) from pluripotent stem cells (stem cells that can generate any type of cells) has […]
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