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Vitamin D: Integrating Environmental Cues into the Developmental Program

Posted by on January 17th, 2019

By Amie L. T. Romney and Jason E. Podrabsky from the Podrabsky Lab at The Center for Life in Extreme Environments at Portland State University     Environmentally-induced developmental plasticity provides an opportunity to explore one of the grand challenges of modern biology – identifying mechanisms that link genotype to phenotype. The annual killifish, Austrofundulus[…]

CENTURI PhD call 2019 – 12 positions available

Posted by on January 14th, 2019

The Turing Centre for Living Systems (CENTURI) wishes to attract talented PhD students to the Luminy campus (Marseille, France) and will fund up to 12 PhD fellowships to start in 2019, for three years. PhD students will work in an interdisciplinary life science environment, and have backgrounds in any of the following fields: cell or developmental[…]

Postgraduate position at Yale University

Posted by on January 9th, 2019

The Giraldez Lab  at Yale University is seeking a highly motivated and enthusiastic research assistant, interested in developing skills in molecular biology and genetics. Our lab uses zebrafish as a model system to study the genetic factors and molecular pathways that regulate early embryonic development. Research topics focus on brain development, disease models, and molecular[…]

Ancient bones in fossils and embryos of living dinosaurs

Posted by on December 20th, 2018

Birds are a dominant group of land Vertebrates (probably the largest in numbers with +10000 species described), highly successful and diverse. Birds originated from members of the Theropoda: the meat-eating dinosaurs that included famous forms like T. rex or Velociraptor, well-known from the movies. The fact that birds are a kind of dinosaur has been[…]

Postdoctoral position in Chromatin and Epigenetics in Drosophila Development

Posted by on December 19th, 2018

Stockholm University, Sweden, invites applications for one postdoctoral position in the laboratory of Professor Mattias Mannervik at the Department of Molecular Biosciences, The Wenner-Gren Institute (http://www.su.se/mbw). The position is scheduled to start as soon as possible. Transcriptional coregulators are proteins that facilitate communication between transcription factors and the basal transcription apparatus, in part by affecting[…]

Visualizing the heterogeneity of single cell data from time-lapse imaging

Posted by on December 12th, 2018

When we examined the kinetics of Rho GTPase activity in endothelial cells in response to receptor stimulation (Reinhard, 2017), we noticed considerable cell-to-cell heterogeneity. In the original work we published graphs with the average response, reflecting the response of the whole cell population. However, these graphs fail to show the cellular heterogeneity. What is the[…]

Immature Cells Zap Around Before Settling Down

Posted by on November 28th, 2018

The story is based on the paper Mechanosignalling via integrins directs fate decisions of pancreatic progenitors, published in Nature, 28 November 2018 Stem cells are already being used in combating previously untreatable diseases. Nevertheless, stem cells are not delivering their full potential because the production of specific cell types from stem cells cannot yet be managed. Researchers[…]

Of Arms and Legs: Shedding light onto developmental gene regulation

Posted by on November 19th, 2018

Written and illustrated by: Bjørt K. Kragesteen, Malte Spielmann, and Guillaume Andrey.   In early development, the forelimb and hindlimb buds of tetrapods are morphologically uniform. However, as limb development proceeds, each individual tissue attains a characteristic morphology that ultimately defines the identity of a forelimb (arm) or a hindlimb (leg). How do undifferentiated limbs[…]

Wire together, remodel together

Posted by on November 15th, 2018

Newborn babies are a symbol of immense potential, as they can grow up to be become virtually anybody, from an astronaut to the president. It is no secret that throughout life, there are critical junctions in which specific events or decisions can direct us on one path or another. Such events occur in our brains;[…]

Sex combs in motion

Posted by on November 14th, 2018

Using computer simulations and mathematical modeling to study the evolution of morphogenesis   Juan N. Malagon and Ernest Ho tell the story behind their recent paper in PLOS Computational Biology. In the Larsen lab, we are interested in testing a 50-year old question: How do sex combs rotate in fruit flies? Despite extensive studies of the[…]