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The Node is a place to share news about and with the developmental biology community around the world. If this is your first time on the site, check out this introduction to the Node. You can also find out more about us, and sign up to contribute.
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Flippase recognition target: orientation matters, so why care?
Posted by Mario Metzler on April 16th, 2014
FRT sites are used often (at least in Drosophila) for inducing deletions or “flipping out” of markers in transgenic constructs. When there are two FRTs sequences in tandem, after inducing flippase the DNA sequence that is between these two sites will be deleted. If two FRT sites are facing each other (or looking away), the […]
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Stone Soup Eyes
Posted by Reed College Dev Neuro on April 16th, 2014
Another installment from the Developmental Neurobiology Students at Reed College. Hope you enjoy! It’s not often that you get to recount the classic tale of Stone Soup when thinking about developmental biology, but that’s exactly what we did when discussing an almost classic 2011 Nature paper from Yoshiki Sasai’s group. In the story, a grumpy […]
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Regenerating the aged thymus
Posted by Caroline Hendry on April 9th, 2014
The latest issue of Development includes a paper by Clare Blackburn and colleagues at the Medical Research Council Centre for Regenerative Medicine, University of Edinburgh, showing that the aged mouse thymus can be regenerated in vivo by the upregulation of a single transcription factor, FOXN1. This work has generated quite a lot of interest in […]
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Identified a new possible target to combat muscle wasting
Posted by IRBBarcelona on April 9th, 2014
The pathological atrophy of skeletal muscle is a serious biomedical problem for which no effective treatment is currently available. Those most affected populations are the elderly diagnosed with sarcopenia and patients with cancer, AIDS, and other infectious diseases that develop cachexia. A study by scientists at the Institute for Research in Biomedicine (IRB), headed by […]
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In Development this week (Vol. 141, Issue 8)
Posted by Seema Grewal on April 8th, 2014
Here are the highlights from the current issue of Development: Spine-tingling new role for Sall4 Wnt, Fgf and retinoic acid signalling play a key role in patterning the posterior neural plate to form the midbrain, hindbrain and spinal cord. Despite intense study of Wnt signalling and neural patterning, only a few target transcription factors […]
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Green Eggs and Serrano Ham
Posted by Mariana Delfino Machín on April 4th, 2014
Scenes from Seville (my pics) and a transgenic embryo (A. Fernandez-Miñan)After over a decade working in Europe, I recently returned to Costa Rica to start a lab at the University of Costa Rica (UCR), in San José. Life in the Tropics has its perks, such as regular sightings of sloths and raccoons from my office […]
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Approaching limb regeneration in an emerging model crustacean
Posted by nkonst on April 1st, 2014
My name is Nikos. I just finished my PhD in the lab of Michalis Averof , starting my thesis at IMBB, in Crete and completing it at IGFL, in Lyon. My project aimed to introduce a new arthropod model to regeneration studies. Its main part was published recently (http://www.sciencemag.org/content/343/6172/788.abstract). In this Node post, I would […]
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Learning to Inject Platynereis Embryos
Posted by Maggie Pruitt on March 31st, 2014
Hello! My name is Maggie Pruitt and I am a postdoc in Dr. Stephan Schneider’s laboratory at Iowa State University. At the beginning of this year, I had the wonderful opportunity to visit Dr. Detlev Arendt’s laboratory at EMBL in Heidelberg, Germany for two weeks. This experience was possible due to a Development Travelling Fellowship […]
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Planarians…the key to regenerative medicine?
Posted by Christele Gonneau on March 31st, 2014
Of all the animal models used in biology, the freshwater planarian flatworm is one of the most fascinating: first because roughly 10% of all planarian cells are stem cells, second because these worms can regenerate from almost any injury. This ability to regenerate entire organs (including their own heads!) makes them very popular for […]
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Mapping the Embryo for Developmental Biologists & Stem Cell Researchers; LifeMap Discovery® – a Roadmap of Mammalian Cell Ontology
Posted by arielrinon on March 30th, 2014
Understanding how cells differentiate during embryonic development is invaluable for the in vitro derivation of functional cells from stem cells. However, mapping the human embryo, including characterization of all the cell types that make up the developing and mature human body, and of all embryonic progenitor cell types that appear in intermediate developmental stages, is […]
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- Spine-tingling new role for Sall4 [IN THIS ISSUE]
- Ageing thymus out-FOXed [IN THIS ISSUE]
- Muscling in on stem cell hierarchy [IN THIS ISSUE]
- Nucleolus precursor body makeover [IN THIS ISSUE]
- Moss stem cells do it differently [IN THIS ISSUE]
- Change of heart for RA signalling [IN THIS ISSUE]
- The evolution and conservation of left-right patterning mechanisms [HYPOTHESIS]
- The Hippo pathway effectors TAZ and YAP in development, homeostasis and disease [REVIEW]
- Spalt-like 4 promotes posterior neural fates via repression of pou5f3 family members in Xenopus [RESEARCH ARTICLES]
- The maternal nucleolus plays a key role in centromere satellite maintenance during the oocyte to embryo transition [RESEARCH ARTICLES]
- The egg membrane microdomain-associated uroplakin III-Src system becomes functional during oocyte maturation and is required for bidirectional gamete signaling at fertilization in Xenopus laevis [RESEARCH ARTICLES]
- Development of five digits is controlled by a bipartite long-range cis-regulator [RESEARCH ARTICLES]
- Msx1 and Msx2 act as essential activators of Atoh1 expression in the murine spinal cord [RESEARCH ARTICLES]
- Type I TARPs promote dendritic growth of early postnatal neocortical pyramidal cells in organotypic cultures [RESEARCH ARTICLES]
- Functional phylogenetic analysis of LGI proteins identifies an interaction motif crucial for myelination [RESEARCH ARTICLES]
- Endothelial cell-derived non-canonical Wnt ligands control vascular pruning in angiogenesis [RESEARCH ARTICLES]
- A Caenorhabditis elegans developmental decision requires insulin signaling-mediated neuron-intestine communication [RESEARCH ARTICLES]
- Pulses of Notch activation synchronise oscillating somite cells and entrain the zebrafish segmentation clock [RESEARCH ARTICLES]
- Genetically encoded molecular probes to visualize and perturb signaling dynamics in living biological systems [Articles of interest in other COB journals]
- Epithelial repair is a two-stage process driven first by dying cells and then by their neighbours [Articles of interest in other COB journals]
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- Dystrophic muscle environment induces changes in cell plasticity [Perspectives]
- DNA methylation dynamics during epigenetic reprogramming in the germline and preimplantation embryos [Reviews]
- The diabetes gene Hhex maintains {delta}-cell differentiation and islet function [Research Communications]
- Coupling 40S ribosome recruitment to modification of a cap-binding initiation factor by eIF3 subunit e [Research Communications]
- HDAC-regulated myomiRs control BAF60 variant exchange and direct the functional phenotype of fibro-adipogenic progenitors in dystrophic muscles [Research Papers]
- miR-99a/100~125b tricistrons regulate hematopoietic stem and progenitor cell homeostasis by shifting the balance between TGF{beta} and Wnt signaling [Research Papers]
- ATR checkpoint kinase and CRL1{beta}TRCP collaborate to degrade ASF1a and thus repress genes overlapping with clusters of stalled replication forks [Research Papers]
- Structural basis for the Nanos-mediated recruitment of the CCR4-NOT complex and translational repression [Research Papers]
- Distinct regulatory mechanisms balance DegP proteolysis to maintain cellular fitness during heat stress [Research Papers]
- Root growth is modulated by differential hormonal sensitivity in neighboring cells [Research Papers]
- Nucleosome-binding activities within JARID2 and EZH1 regulate the function of PRC2 on chromatin [Errata]
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