the community site for and by developmental biologists

Unraveling tissue interactions coordinating neuromuscular morphogenesis: a journey through serendipity

Posted by on June 20th, 2018

An emerging trend in developmental biology focuses on the role of cell adhesion in modulating tissue morphogenesis. Spectacular advances have shed light on how modulation of adhesion between equivalent cells orchestrates the acquisition of forms. However, how interactions at complex interfaces between distinct neighboring cell types influence tissue growth remains to be elucidated. In a[…]

Lighting Up the Central Dogma in Development

Posted by on June 19th, 2018

We recently published a manuscript in Cell that describes a method to image transcription factor concentration dynamics in real time, in living embryos, using a nanobody-based protein tag that we call the “LlamaTag.” We were particularly excited about these investigations because this new technology overcomes a major technical obstacle to understanding how gene-expression dynamics are[…]

Gene Regulatory Networks for Development

Posted by on June 19th, 2018

Applications are now open for this year’s Gene Regulatory Networks for Development which will be at The Marine Biological Laboratory in Woods Hole, USA from October 14- 27.  The application deadline is July 20.  The course is for graduate students, postdoctoral researchers, and faculty members and it focuses on using experimental data and computational modeling to analyze gene regulatory[…]

New embryo phenotype data from the DMDD programme

Posted by on June 15th, 2018

Following our latest data release, the DMDD website (dmdd.org.uk) now contains detailed phenotype data for nearly 700 embryos from 82 different knockout mouse lines. Highlights include the identification of limb defects and cysts in Col4a2 knockouts and replication of the major features of Meckel syndrome in B9d2 knockouts. We have begun to add immunohistochemistry image[…]

Call for papers: Development at the single cell level

Posted by on June 14th, 2018

Development is pleased to welcome submissions for an upcoming special issue on ‘Development at the single cell level’. This special issue aims to showcase the best research in stem cell and developmental biology, building on the rapidly evolving tools of single cell analysis. The issue will be guest-edited by Allon Klein and Barbara Treutlein, working alongside our team of[…]

Polarizing morphogenesis: epithelia dance the polonaise

Posted by on June 13th, 2018

The story behind our recent paper: Counter-rotational cell flows drive morphological and cell fate asymmetries in mammalian hair follicles. Maureen Cetera, Liliya Leybova, Bradley Joyce & Danelle Devenport, Nature Cell Biology.    Planar cell polarity (PCP) is a fascinating biological problem because it spans such vast biological scales, from nanometers to meters of spatial organization. When[…]

Lessons from the 11th Annual NIH Career Symposium

Posted by on June 12th, 2018

For a Ph.D. holder, the idea that any career can be classified as “alternative” is obsolete. With a smaller percentage of postdocs going on to tenure-track positions every year, universities and research institutions are stepping up efforts to help recent graduates figure out how to put to good use all the specialized training that they[…]

The people behind the papers – Kana Ishimatsu, Tom Hiscock & Sean Megason

Posted by on June 12th, 2018

Somites are segmented structures  which give rise to numerous tissues in the vertebrate body. It has long been observed that somites scale in size with the overall size of the embryo, both as development proceeds and between individuals of different sizes, but the molecular underpinnings of this process have remained controversial. A new paper in[…]

How to Grow a Network on the Go

Posted by on June 8th, 2018

Transportation networks play a central role in enabling efficient mass flow over extended domains, where diffusion alone would be too slow. Therefore, transportation networks often play a central role for an organism’s physiology and a high degree of energetic efficiency has been proposed as a guiding principle for the layouts of these networks. However, biological[…]

The Anatomical Society Summer Meeting ‘Human Cerebral Cortex Development’

Posted by on June 7th, 2018

Summer Meeting of the Anatomical Society Theme: Human Cerebral Cortex Development Venue: St. John’s College, University of Oxford, Oxford, UK Dates: 23-25 July 2018 Many human psychiatric and neurological conditions have developmental origins. Rodent models are extremely valuable for the investigation of brain development, but cannot provide insight into aspects that are specifically human. The human[…]