the community site for and by developmental biologists

Gene editing stem cells with CRISPR could help understand brain tumours

Posted by on February 14th, 2017

This report written by Justine Alford and highlighting a recent Development paper originally appeared on the CRUK Science Blog.      Over the past 12 months, the acronym CRISPR has been popping up in science news left, right and centre. And for good reason. Hailed as a revolution in genetic engineering, this molecular toolbox lets[…]

Uncovering Non-canonical Roles of E-cadherin Beyond Cell Adhesion

Posted by on February 14th, 2017

Broad perspective Successful division was an essential criterion for establishing the cell as the basic unit of life on earth. Later, cell-cell adhesion made possible the evolution of multicellular life forms. These two fundamental cellular processes co-function throughout the life of an organism, during development, wound healing and tissue regeneration. In epithelial tissues this results[…]

In Development this week (Vol. 144, Issue 4)

Posted by on February 14th, 2017

Here are the highlights from the new issue of Development:   A new mechanism in ESC lineage priming Histone demethylases have recognized roles in the control of gene expression during development and disease, and are typically associated with the remodelling of the chromatin environment. Jmjd2/Kdm4 H3K9-demethylases cooperate in promoting mouse embryonic stem cell (ESC) identity,[…]

Meeting review: BSDB/Anne McLaren Memorial Trust 2016 Autumn Meeting

Posted by on February 10th, 2017

The use of chimaeras to study developmental mechanisms: from lineage tracing to disease models   Under the sponsorship of the Anne McLaren Memorial Trust Fund and The Company of Biologists, the BSDB Autumn meeting organised by Jenny Nichols and Tristan Rodriguez took place in the Pollock Halls at the University of Edinburgh. The topic this[…]

Transposons in Embryo Space – TRACER maps in EMAGE

Posted by on February 9th, 2017

A recent publication in Developmental Biology by (Armit et al., 2017) describes how the TRACER dataset can be spatially compared with in situ hybridisation gene expression profiles.   The TRACER dataset of transposon-associated regulatory sensors (Chen et al., 2013) utilises Sleeping Beauty lacZ transposons that have been randomly integrated into the mouse genome Hundreds of[…]

YEN Conference 2017: Registration open now!

Posted by on February 8th, 2017

Young Embryologist Network 9th Annual Conference. 9th May 2017 at the Institute of Child Health, UCL, London. This year, YEN is honoured to have Dr Darren Gilmour from EMBL Heidelberg present the Sammy Lee Memorial Lecture. We are also pleased to host two invited speakers, Dr Karen Liu (King’s College London), and Professor Michael Stumpf (Imperial College London). As well as three abstract-selected talk sessions and a poster[…]

The people behind the papers #13

Posted by on February 8th, 2017

Radial glial cells are multipotent progenitors in the developing vertebrate brain. At their apical interface with the ventricular cavity around which the brain forms, they bear a primary cilium, a signalling and sensory organelle crucial for proper brain development. Today’s paper, from a recent issue of Development, addresses the link between these primary cilia and brain morphogenesis.[…]

D’Arcy Thompson’s On Growth and Form – 100 Years On and Still Growing!

Posted by on February 7th, 2017

“For the harmony of the world is made manifest in Form and Number, and the heart and soul and all the poetry of Natural Philosophy are embodied in the concept of mathematical beauty.”     D’Arcy Thompson’s On Growth and Form, which celebrates its centenary this year, is one of the key works at the[…]

New data reveals how gene knockouts affect whole embryo gene expression

Posted by on February 7th, 2017

New DMDD data released on Expression Atlas reveals the effect of single gene knockouts on the expression of all other genes in the mouse genome. The gene expression profiles of 11 knockout lines have been derived from whole embryos harvested at E9.5, and the results can be compared with wild-type controls using an interactive online[…]

This month on the Node and beyond

Posted by on February 7th, 2017

January was a productive month on the Node, with a variety of developmental biology content from the lab bench and beyond.   Research We heard from the authors of a bunch of recent papers, including Ripla Arora on her recent Development paper on imaging the implanting embryo and uterine environment in 3D, and Kyle Martin[…]