the community site for and by developmental biologists

A glimpse of a dynamic cell fate decision

Posted by on October 27th, 2017

Andras Paldi, Daniel Stockholm, Alice Moussy How do phenotypic differences between cells of the same clonal origin emerge? How exactly does the transition between the initial and final phenotypes occur? What happens in the cell during the transition? When there are two or more options, how is the choice made between them? How long does[…]

PhD Advice From the Twitter Hive Mind

Posted by on October 26th, 2017

Doing a PhD is tough, the data from surveys supports that. However it is not insurmountable, and here we have a collection of some guidance from the Twitter community.  Let us know in the comments if you have any thoughts to add.   [View the story “PhD Survival” on Storify]   (No Ratings Yet) Loading…

Christiana Ruhrberg, winner of the BSDB Cheryll Tickle Medal 2018

Posted by on October 24th, 2017

In 2016, the BSDB introduced the Cheryll Tickle Medal, which is being awarded annually to a mid-career, female scientist for her outstanding achievements in the field of Developmental Biology. The BSDB is proud to announce the 2018 awardee Christiana Ruhrberg. The medal will be presented at next year’s Spring Meeting where Christiana will give the[…]

BSDB Gurdon Summer Studentship Report (12)

Posted by on October 24th, 2017

Established  by the British Society for Developmental Biology in 2014, The Gurdon/The Company of Biologists Summer Studentship scheme provides financial support to allow highly motivated undergraduate students an opportunity to engage in practical research during their summer vacation. Each year, ten successful applicants spend eight weeks in the research laboratories of their choices, and the feedback[…]

Regulation of cell polarity by EGF signaling controls both organ architecture and cell fate

Posted by on October 23rd, 2017

Scientists at DanStem discovered that cells’ sense of direction (cell polarity) determines their destiny. By discovering the signals that control cell polarity in the developing organism, scientists can now mimic it in a test tube and control the fate of human stem cells. The results accelerate the efforts to generate specialized cells, e.g. insulin-producing beta[…]

Glia lead the way for pioneers to build the brain neuropil in C. elegans

Posted by on October 20th, 2017

It’s all about the wires. But what about the glue? Networks make us who we are. I am not talking about social networks but about neural networks that define how we perceive the world and how we act. For a century, neuroscientists have sought to understand functions of neural networks in condition and how such[…]

Guidelines for morpholino use in zebrafish

Posted by on October 20th, 2017

If you work with zebrafish or Morpholinos, please read this. Guidelines for morpholino use in zebrafish. Stainier DYR, Raz E, Lawson ND, Ekker SC, Burdine RD, Eisen JS, Ingham PW, Schulte-Merker S, Yelon D, Weinstein BM, Mullins MC, Wilson SW, Ramakrishnan L, Amacher SL, Neuhauss SCF, Meng A, Mochizuki N, Panula P, Moens CB. PLoS[…]

The right information

Posted by on October 19th, 2017

Oscar H. Ocaña and M. Angela Nieto Comment on “A right-handed signalling pathway drives heart looping in vertebrates”. Nature 549, 86-90 (2017).   A fundamental aspect of vertebrates is their external bilateral symmetry, which has to some extent shaped evolutionary success. Not only is beauty associated with symmetry, enhancing an individual’s chance of mating but[…]

The people behind the papers – Sabrina Jan, Tinke Vormer, Sjoerd Repping and Ans MM van Pelt

Posted by on October 18th, 2017

During spermatogenesis, progenitor cells must undergo tightly regulated changes to produce functional gametes. However, the genetic control of this process in humans has eluded researchers. This week we feature a paper published in the latest issue of Development that describes the changing genetic expression of cell during spermatogenesis. The co-first authors Sabrina Jan and Tinke[…]

Forgotten classics: Making a monotreme

Posted by on October 17th, 2017

T. Thomson Flynn and J.P. Hill. 1939. The Development of the Monotrema – Part IV. Growth of the Ovarian Ovum, Maturation, Fertilisation and Early Cleavage. Transactions of the Zoological Society of London, 24, 445-623. T. Thomson Flynn and J.P. Hill. 1947. The Development of the Monotrema – Part VI. The Later Stages of Cleavage and[…]