A Postdoctoral position is available in the Charalambous lab in the Department of Medical and Molecular Genetics at King’s College, London. Our team investigates genetic and epigenetic determinants of mammalian body composition. The candidate will be part of an exciting collaboration with the University of Bath, investigating the role of imprinted genes in adipose tissue development and turnover.
There is considerable phenotypic variation of body composition in the human population. This is clinically important because while some people maintain their health when exposed to a ‘Western’ lifestyle others develop obesity and associated metabolic disorders such as Type II Diabetes and cardiovascular disease. There is strong evidence that a large component of the variation in body composition is genetic, and furthermore – many of the genes may be acting in developmental pathways to modify skeletal muscle mass and adipose plasticity for a lifetime. By using in-vivo models to manipulate lean:adipose distribution we hope to identify the genetically determined developmental pathways that determine body composition, and understand how their compromise predisposes to metabolic disease.
The candidate will be part of a team based at Guy’s Campus, King’s College London, embedded within a centre of excellence for developmental biology and stem cell research. Moreover, the Department of Medical and Molecular Genetics has recently recruited a critical mass of researchers in the field of epigenetics, providing a strong source of crossover opportunities with this project.
Applicants should have a recent Ph.D. degree or M.D./Ph.D. degree. Candidates with experience in stem cell and/or developmental biology, confocal microscopy, image acquisition and analysis will be preferred, as will those with bioinformatics skills. This position seeks a highly motivated individual with a strong interest in developmental biology.
The position is open starting from December 2018.
Please apply via the KCL portal below:
Dr. Marika Charalambous, Department of Medical and Molecular Genetics, KCL, London, UK