Postdoc position in Developmental Biology in Mukhopadhyay lab, UT Southwestern, Dallas.
The focus of the current research in the Mukhopadhyay laboratory is to understand mechanisms of cellular signaling at the level of the primary cilia, and its relevance to human health and disease. The first cellular organelle to be described in biology, the primary cilium was long mistaken as a vestigial appendage. The primary cilia are now considered as vital sensory organelles for detection and transmission of a broad range of chemical and mechanical signals in most cells. Signaling mediated by the primary cilia plays fundamental roles in cellular differentiation, polarity and cell cycle control. We utilize a variety of biochemical, cell biological and reverse genetic approaches to understanding signaling mediated by cilia, and dissecting their role during normal development and carcinogenesis. A detailed description of current lab projects can be found at: http://www.utsouthwestern.edu/labs/mukhopadhyay/ and a recent invited review in MBoC.
One postdoctoral position is available in our laboratory to study the role of cilia and cilia-generated signaling in multiple developmental processes. We are a closely-knit group of scientists with diverse sets of expertise and passionate about solving the particular biological problem, often embarking on newer methods and paradigms as necessary. We are located in the Department of Cell Biology in UT Southwestern Medical Center, Dallas. UT Southwestern, one of the premier academic medical centers in US, integrates pioneering biomedical research with exceptional clinical care and education. The institution’s faculty includes many distinguished members, including six who have been awarded Nobel Prizes since 1985.
Developmental biology questions include but are not restricted to the role of cilia in limb bud formation, skeletal morphogenesis including intramembranous bone formation, neural tube patterning, cerebellum and brain development.
Our recently accepted paper (in press in Development) on orphan cilia-localized GPCR, Gpr161 and limb development is available to interested candidates upon request. Here we demonstrate that Gpr161 promotes forelimb formation, regulates limb patterning, prevents periarticular chondrocyte proliferation, and drives osteoblastogenesis in intramembranous bones in a cilium-dependent manner.
Another paper on Gpr161 and cerebellum development and tumorigenesis (currently in review) is also available upon request. Here we demonstrate that Gpr161 restricts cerebellar granule progenitor production by preventing premature and sonic hedgehog-dependent pathway activity, highlighting importance of basal pathway suppression in medulloblastoma pathogenesis.
Candidates must have a recent Ph.D. or M.D./Ph.D., with less than three years of prior postdoctoral experience, and a demonstrated research record with at least one first author publication. Preference will be given to applicants with a strong background in cell and molecular biology or mouse genetics.
Interested individuals should email firstname.lastname@example.org a copy of your current curriculum vitae, contact information for references, and a cover letter highlighting your prospective research plan.
UT Southwestern Medical Center is an Affirmative Action/Equal Opportunity Employer. Women, minorities, veterans and individuals with disabilities are encouraged to apply.