Grade 7 £28,983 – £35,646
We are seeking two Post-Doctoral Research Assistants for Professor Liz Robertson’s Wellcome Trust funded Research Group studying mammalian developmental biology at the Sir William Dunn School of Pathology.
Our programme focuses on defining the molecular cues responsible for cell allocation and tissue morphogenesis in the developing mammalian embryo. We have exploited transgenic and ES cell technologies to investigate the key signalling pathways and transcriptional networks that regulate expansion of diverse progenitor cell populations. Candidates with experience in construct design, high resolution imaging, cell sorting, microarrays, ChIP and/or proteomic approaches would be especially welcome. We are seeking well trained and ambitious scientists with good organisational and communication skills.
Arnold and Robertson (2009). Making a commitment: cell allocation and axis patterning in the early mouse embryo. Nature Rev. Mol. Cell Biol. 10, 91-103
Morgan et al. (2009) Blimp-1/Prdm1 alternative promoter usage during mouse development and plasma cell differentiation. Mol. Cell. Biol. 29, 5813-27
Costello et al. (2009) Smad4-dependent pathways control basement membrane deposition and endodermal cell migration at early stages of mouse development. BMC Developmental Biology 9, 54-70
Arnold et al. (2008) The transcription factor Eomes/Tbr2 regulates neurogenesis in the embryonic subventricular zone. Genes Dev. 22: 2479-84.
Maretto et al. (2008) Ventral closure, headfold fusion and definitive endoderm migration defects in mouse embryos lacking the fibronectin leucine-rich transmembrane protein FLRT3 Dev. Biol. 318: 184-193.
Arnold et al. (2008) Pivotal roles for Eomesodermin during axis formation, epithelium-mesenchyme-transition and endoderm specification in the mouse. Development 135:501-511.
Robertson et al. (2007) Blimp1 regulates development of the posterior forelimb, caudal pharyngeal arches, heart and sensory vibrissae in mice. Development 134: 4335-45.
To apply please send your CV, a cover letter and contact details of 2-3 referees to firstname.lastname@example.org. Please quote reference LR/10/008