Laboratory: Laboratory of developmental biology, dr. Alena Krejci, Biology Centre, Czech Academy of Sciences, Ceske Budejovice, Czech republic
In the lab we aim to dissect the interplay between metabolism and major signalling pathways, with emphasis on the Notch signalling pathway.
Project: Metabolic stress as regulator of Notch signalling
The Notch pathway has been described in several contexts to regulate glycolytic as well as mitochondrial metabolism (including paper from our lab Slaninova V, Open Biology, 2016). At the same time, recent evidence suggest that Notch pathway activity is sensitive to the cell metabolic parameters, such as the NAD:NADH ratio, amino acid availability or activity of metabolism related signalling pathway such as mTOR (Horvath M, Biochem J, 2016 and our current paper in preparation). We investigate this interplay using Drosophila wing disc, eye disc and immune system as models. The theme of the postdoc/PhD project can be defined according to the postdoc/PhD previous experience and interests, but it could be directed to characterization of mitochondria as regulators of Notch directed proliferation, to identification of binding sites for a Notch targeted transcription factor involved in metabolism or to in vivo analysis of metabolic parameters via genetically encoded metabolic sensors.
Applicant: Applicant should have a degree in molecular or cellular biology. Previous experience with Drosophila, molecular biology techniques and/or confocal microscopy is welcome.
Position: Postdoc offer includes a 2-year contract with the possibility of extension. PhD position is a part of the 4-year PhD program at the Department of molecular biology and genetics, University of South Bohemia. More details of the Departments at http://kmb.prf.jcu.cz
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