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Zebrafish knock-ins swim into the mainstream

Posted by on October 25th, 2018

This Editorial by Sergey Prykhozhij and Jason Berman originally appeared in Disease Models and Mechanisms, an online Open Access sister journal to Development focusing on the use of model systems to better understand, diagnose and treat human disease. The Editorial focuses on three new papers on point mutant knock ins in zebrafish, and will thus be of interest[…]

New DMM Collection focused on Neurodegenerative Diseases

Posted by on May 3rd, 2017

A growing aging population means that age-dependent neurodegenerative disorders such as Alzheimer’s disease, Parkinson’s disease, Huntington’s disease and amyotrophic lateral sclerosis are affecting increasing numbers of people, making research into these diseases more important than ever. As a crucial resource for researchers and to showcase the vital research being done in the field, Disease Models[…]

Spotlight on Rat: Translational Impact – a new DMM Special Collection

Posted by on October 18th, 2016

Disease Models & Mechanisms is pleased to announce the launch of a new Special Collection named Spotlight on Rat: Translational Impact. The rat is a key model for basic and preclinical studies of physiology, pharmacology, toxicology and neuroscience, underlining its importance in studies of human disease. There are many reasons for its suitability as a[…]

Call for Papers: a Special Collection on Neurodegenerative Diseases

Posted by on May 31st, 2016

Disease Models & Mechanisms invites you to submit original research for consideration for an upcoming Special Collection ‘Neurodegeneration: From Models to Mechanisms to Therapies‘. This ongoing collection will focus on mechanistic insights into neurodegenerative diseases using model systems, with an emphasis on key translational advances made in recent years. This collection will be launched with[…]

Introducing a new Special Collection, Spotlight on Drosophila: Translational Impact

Posted by on March 3rd, 2016

In the latest issue, Disease Models & Mechanisms (DMM) launches a Special Collection that focuses on translational advances made using the Drosophila model, including insights into disease mechanisms, emerging technologies and therapeutic advances. This Collection, guest edited by Norbert Perrimon and Nancy M. Bonini, includes a poster article on tools and assays for fly research (from[…]

Using the mouse to model human disease: increasing validity and reproducibility

Posted by on February 3rd, 2016

This editorial by Monica J. Justice and Paraminder Dhillon was first published in Disease Models & Mechanisms.   ABSTRACT Experiments that use the mouse as a model for disease have recently come under scrutiny because of the repeated failure of data, particularly derived from preclinical studies, to be replicated or translated to humans. The usefulness of[…]

From our sister journals- January 2016

Posted by on January 26th, 2016

Here is some developmental biology-related content from other journals published by The Company of Biologists.     Characterisation of Slc9a6 knockout heterozygous female mice Mutations in SLC9A6 are responsible for X-linked Christianson syndrome, a neurodevelopmental disease. Sikora and colleagues demonstrate that female mice heterozygous for a Slc9a6 knockout present mosaic neuropathology and similar but milder behavioural traits to those of affected[…]

From our sister journals- December 2015

Posted by on December 17th, 2015

Here is some developmental biology-related content from other journals published by The Company of Biologists.     A mouse model for tuberous sclerosis complex The authors present a mouse model for tuberous sclerosis complex in which the gene Tsc1  is ablated from eye-progenitor cells, leading to the classic hallmarks of the disease. This demonstrates a[…]

An interview with Tatsushi Igaki

Posted by on December 10th, 2015

This interview first featured on Disease Models and Mechanisms.   Tatsushi Igaki is currently based at the Kyoto University Graduate School of Biostudies, where he leads a research group dedicated to using Drosophila genetics to build a picture of the cell-cell communications underlying the establishment and maintenance of multicellular systems. His work has provided insight[…]

Announcing DMM’s special issue ‘Spotlight on Zebrafish: Translational Impact’

Posted by on July 6th, 2014

In recent years, the zebrafish has emerged as an increasingly prominent model in biomedical research. Its optical transparency for the first few weeks, high fecundity and ex vivo fertilization have made it traditionally suitable to study developmental biology. However, over the past decade these same features have enabled the zebrafish to become a preeminent disease model and[…]