Post-doctoral positions in the Bray lab: Notch regulatory dynamics.

The Bray lab has an opening for two Research Associates. Our collaborative, multidisciplinary team is investigating Notch regulatory networks in development and their relevance to disease.  One project will focus on epigenetic mechanisms that remodel enhancers during cell fate transitions to programme the correct response to signalling (for example to maintain stem cells or promote differentiation depending on the context) and that enable enhancers to select the correct promoter.   The other project will investigate how Notch signals are decoded in real time in vivo and will involve live-imaging of transcription and of nuclear complexes, including single molecule tracking of transcription factors in living tissues.  The projects build on exciting assays we have recently developed (Falo Sanjuan et al., 2019, Dev Cell 50:411-425.e8; Gomez-Lamarca et al., 2018, Dev Cell 44:611-623.e7) and will involve generating new tools, including optogenetics, through genome editing and other approaches.

We are looking to recruit highly motivated scientists with strong investigative skills.  You should have a PhD (or soon to be awarded your PhD) and experience in one or more of the following, molecular biology, epigenetics, developmental biology, cell biology, Drosophila genetics. Experience of genome-wide transcriptional analysis would be an advantage for one position and of advanced imaging and image analysis for the other.

For more information and link to the on line application: http://www.jobs.cam.ac.uk/job/24821/

Further information about our research can be found at: http://www.pdn.cam.ac.uk/staff/bray_s/index.shtml.  For informal enquiries, please email Prof Bray at: sjb32@cam.ac.uk.

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