Postdoc position in the Ameen laboratory

A position is available for a Post Doctoral Associate 1 in the Ameen Lab, within the Section of Digestive Diseases at Yale School of Medicine. Dr. Ameen is a pediatric gastroenterologist and physician scientist. She is Professor Pediatrics, Cellular and Molecular Physiology, and has been investigating CFTR in the intestine for over 25 years. Collaborative studies are ongoing with Dr. Kaelyn Sumigray in the Department of Genetics. This is a wonderful opportunity to learn complementary skills from the laboratory of a physician-scientist and basic stem cell geneticist.

A major goal of the Ameen laboratory is understanding the regulation of CFTR chloride channels in the native intestine and its relevance to intestinal diseases. Studies are predominantly conducted in animal models, including normal rat, transgenic mouse models of diseases where CFTR is implicated. We also conduct studies in human intestinal organoids and cultured human intestinal cells.  Studies in the Sumigray lab focus on intestinal stem cell biology. Collaborative project with the Sumigray lab is using single cell RNA-sequencing and cutting edge techniques to examine and characterize a unique enterocyte subtype in the intestine and its relevance to Cystic Fibrosis. Yale is a very collaborative environment with many opportunities to interact with scientists and physician-scientists on campus.

Techniques used in the laboratory include: PCR, qPCR, tail clipping, animal husbandry, cell and organoid culture, Ussing Chamber electrophysiology in tissues and cells, immunofluorescence staining of cells and tissues, fluorescence and confocal microscopy imaging, immunoblot analysis of rodent tissue lysates, co-immunoprecipitation using tissue lysates, Ussing chamber electrophysiology.

Interested candidates please contact the PI: Nadia Ameen, Professor Pediatrics, Cellular and Molecular Physiology at Nadia.Ameen@yale.edu

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