Epithelial Stem Cell – Niche Interactions in Lung Development, Homeostasis, Regeneration and Disease Virtual Conference
Posted by Gemma Wright, on 1 July 2021
In the last years, a significant advance in the field of respiratory stem cell biology has occurred. It has acquired deeper knowledge about the identity, regulation and functions of lung epithelial stem cells during development, homeostasis, regeneration and disease. Even novel lung epithelial progenitor cells that develop after injury and that are necessary intermediates during regeneration have been identified.
Lung stem cell niches including supportive stromal cells as well as the extracellular matrix (compounds and biomechanics) where they are embedded in, are currently better defined. However, there is still little knowledge about the regulation of lung stem cell behaviour by the niche and further investigation is required. Understanding the interactions between lung stem cells and their niche as well as studying how changes in the local microenvironment affect stem cell behaviour, will contribute to comprehend the development of disease and to discover novel therapeutic approaches.
The discussions will include but not be limited to:
- Airway and Alveolar Stem cells in lung health and disease
- Novel epithelial progenitor cell populations
- Epithelial-mesenchymal interactions in lung development, regeneration and disease
- Embryonic lung stem cell niche in lung development
- Stem cell niches in lung homeostasis and repair
- Mechanical regulation of lung stem cells
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