POSTDOCTORAL FELLOWS- Cellular communication in cancer, development and neurotransmission

We are seeking to fill two postdoctoral positions broadly related to the topic of signal transduction via G protein-coupled receptors (GPCRs). Our laboratory is in a phase of expansion with multiple active NIH-funded grants to provide stable support for personnel. You would join a dynamic team of international researchers (PhD students and other postdocs) with an interest in collaborating and helping each other. Dr. Garcia-Marcos seeks to mentor the next generation of scientists by providing abundant one-on-one time and the support required to transition into subsequent career stages, including establishing their independent research programs. The laboratory has an excellent track record of facilitating the transition of former postdoctoral fellows to competitive positions.

We are located at the heart of Boston, a scientifically and culturally vibrant location. The minimum salary is $58,000/ year plus a sign-on bonus for relocation expenses. Health plan and other benefits included.

Our laboratory is interested in the following general lines of investigation:

• Defining new mechanisms of signal transduction via GPCRs and heterotrimeric G proteins across scales, from molecules to whole organisms
• Non-canonical heterotrimeric G protein signaling in epithelial planar cell polarity, cilia and development
• Development of optical biosensors and chemogenetic tools to detect and manipulate the signaling activity of heterotrimeric G proteins
• Characterization and pharmacological targeting of non-canonical heterotrimeric G protein signaling in cancer metastasis
• Biochemical, functional and structural characterization of atypical G protein signaling complexes.

The candidate should have at least one of the following technical skillsets:

• Extensive experience with fluorescence microscopy and image analysis. Live-cell microscopy desirable.
• Xenopus and/or zebrafish experience. Egg microinjections and other general aquatic model procedures.
• High proficiency in cell culture. Viral gene delivery, generation of stable cell lines, different types of cells (e.g., transformed and non-transformed, primary cell cultures), signaling assays. Basic knowledge of mouse colony maintenance desirable.
• Fast paced in molecular biology (cloning by Gibson assembly, Golden Gate, etc), and knowledge of protein purification (batch, FPLC) and protein binding assays (pulldowns, immunoprecipitations). Structural biology background desirable.

See “Representative publications” by scrolling down in: https://www.bumc.bu.edu/biochemistry/profiles/mikel-garcia-marcos/

Complete list of publications in: https://www.ncbi.nlm.nih.gov/myncbi/1ZIXmzi80H8Q6/bibliography/public/

Please submit a cover letter with details on what project you want to pursue, a CV and names/contact for 3 reference letters. Mikel Garcia-Marcos, PhD. Professor.  mikel.garcia.marcos@gmail.com