Postdoctoral Fellow, Computational Biology

The New York Stem Cell Foundation (NYSCF) Research Institute is a growing and successful nonprofit whose mission is to accelerate cures through stem cell research.

NYSCF is seeking a recent PhD for a position as Postdoctoral Fellow within the Computational Biology team. You will be responsible for developing novel algorithms and custom analysis pipelines that leverage the extensive omics data sets on cell reprogramming and differentiation created at NYSCF. You have experience in machine learning and are ideally familiar with multiple omics modalities, such as (single-cell / spatial) transcriptomics, genomics, ATAC-seq etc. You are either knowledgeable about stem cell biology or eager to learn about it and keen on using your computational skills to contribute to the improvement of human health. You will report to the VP, Computational Biology. We are looking for a creative, independent scientist who can derive relevant biological insights from high-throughput molecular profiling data and collaborate efficiently with experimental colleagues at NYSCF as well as industry partners. This position allows for hybrid work onsite and remote, with at least two days per week onsite at NYSCF in Manhattan.

What you’ll do

• • Develop innovative approaches to extract novel biological insights and infer predictive models (e.g., gene regulatory networks) from high-throughput data
  • Collaborate closely with experimental colleagues on the biological interpretation of molecular profiling results, as well as their experimental validation
  • Stay on top of the current scientific literature and generate project ideas using new deep / machine learning methods as well as novel concepts in stem cell or disease biology
  • Work on a broad range of data analysis projects with groups at NYSCF and partner organizations, for example from the pharmaceutical industry
  • Advise on experiment design and requirements for replication, quality control, reporting and meta data towards optimal reusability of the generated data
  • Develop and implement novel data visualization strategies to summarize results and QC features
  • Assist in structuring and managing our cloud-computing environment that runs batch jobs to process and analyze our sequencing data at scale, coordinating with software engineering team as needed
  • Generate reports and data summaries to be presented both internally and to external collaborators
  • Contribute to publications and conference presentations
  • Support research teams in developing analysis pipelines, which might include script writing/coding and troubleshooting, and educate colleagues about relevant statistical or machine learning concepts

What we’re looking for

• • Recent PhD in Computer Science, Statistics, Computational Biology, Bioinformatics or similar field
  • Knowledge of or strong interest in stem cell research
  • Knowledge of sequencing technologies such as (single-cell) RNA-Seq, ChIP-Seq, ATAC-Seq
  • Experience with aligners such as Bowtie, Trinity, Salmon or Kallisto
  • Experience with tools for the statistical analysis of biological data (for example: DESeq2 for differential expression testing)
  • Advanced programming skills in Python and/or R
  • Knowledge of additional programming languages, such as Java or C++ is a plus
  • Experience with database integration (using SQL) and maintenance, as well as interfacing with a LIMS are a plus
  • Grasp of basic molecular biology and genetics wet-lab techniques is a plus
  • Familiarity with cloud computing infrastructures on AWS and working with cloud-based tools such as AWS Batch, Data Pipeline, RDS/Redshift is a plus
  • Experience with visualization tools such as Tableau, Matplotlib, ggplot2 or TIBCO Spotfire is a plus

This position’s base starting salary range is $60,000 – $72,000. Final offer amounts and levels are determined by multiple factors, including your experience, and may vary from the amounts listed above.

Studies have shown that women and people of color are less likely to apply for jobs unless they meet every single qualification. At NYSCF, we believe diversity in all ways makes us a better team, and we celebrate it. So, if you’re excited about this role but your past experience doesn’t align perfectly with every qualification in the job description, we encourage you to apply anyways. You may be just the right candidate for this or other roles.

We offer all full-time employees a comprehensive benefits package that goes into effect on the first of the month following your start date. It includes a choice of medical, dental, and vision insurance (with 100% of the premiums paid for employees and subsidies for any dependents), 403b retirement plan with 5% employer match (immediate vesting schedule which starts after your first 90 days), short and long term insurance, life insurance, inclusive paid parental leave program, pretax transit and parking, legal aid benefits and wellness benefits. Our paid time off includes vacation, sick, personal days, flexible holidays, summer flex program, and all company holidays. If a visa is required, NYSCF will cover all of those costs. Relocation will sometimes be necessary; therefore, we will provide you with an allowance.

In compliance with federal law, all persons hired will be required to verify identity and eligibility to work in the United States and complete the required employment eligibility verification upon hire.

NYSCF is an equal-opportunity employer, and we value diversity in our company. It ensures equal employment opportunity without discrimination or harassment based on race, color, religion, sex (including pregnancy, childbirth, or related medical conditions), sexual orientation, gender identity or expression, age, disability, national origin, marital or domestic/civil partnership status, genetic information, citizenship status, veteran status, or any other characteristic protected by law.

The position is based at our location in Manhattan. Our Research Institute facility is a fully COVID-19-vaccinated workplace.