Postdoctoral Scholar – Human Embryo Development and Reproductive Organoid Platform Engineering
Posted by Postdoctoral Administrator, on 29 July 2023
Job type: Postdoc
Location: Stanford University, CA, USA
Closing Date: 1 November 2023
Are you passionate about making ground-breaking contributions to the fields of human embryo development and reproductive organoid research? Join our newly established lab at Stanford, where you will be able to drive scientific discoveries and advance our understanding on the very early stages of human embryo development. The position will be for a 2-year fixed term contract with possibility of extension. Salary per annum from $71,650, dependent upon skills and experience.
Position Summary:
We are seeking a highly motivated Postdoctoral Scholar to lead a multi-faceted project focusing on investigating fundamental mechanisms of human embryo implantation. This is a unique opportunity to work at the intersection of developmental biology and advanced organoid research, utilizing innovative methodologies and technologies. Our research objectives are to elucidate the cellular behavior, adhesion, invasion, and interactions between the embryo and maternal issue, and to employ single-cell technologies to profile the molecular cross-talk of the implantation niche. By studying what goes wrong at the embryo-maternal interface, we aim to gain critical insights into the molecular causes underlying implantation failure and early pre-clinical miscarriages. For further information please contact Dr. Matteo Molè at mmole@stanford.edu or visit our website.
Key Responsibilities:
• Lead a project examining the cellular and genetic regulation of human embryo implantation.
• Collaborate closely with other members within the Department and wider Stanford community to advance the development of advanced reproductive platform models, already established in the lab. The project will involve engineering major cellular compartments (epithelial, stromal, immune, endothelial cells) to mimic physiological and pathological endometrium and to study early stages of placentation.
• Employ advanced imaging, spatial analysis, and sequencing-based technologies to dissect mechanism of embryo development and explore gene regulation. Establish live imaging protocols.
• Work with stem cell-derived embryo models to compare in vitro and in vivo development, and conduct genetic and drug screens using the reproductive platform models.
• Maintain meticulous records and support operational and reporting responsibilities associated with clinical research, samples collection and collaborations with IVF clinics.
Apply HERE
Salary: 71,650.00 USD
Closing Date: 1 November 2023
Scientific fields: Cell fate control and differentiation
Model systems:
Duration: Fixed term
Minimum qualifications: • PhD in Developmental Biology, Genetics, Cell and Molecular Biology, or a related field. • Strong background and expertise in embryonic stem cell culture, organoids, and developmental biology. • Experience with advanced imaging techniques. Familiarity with spatial analysis including sequencing-based spatial technologies would be desirable. • Experience with single-cell transcriptomic. Familiarity with multi-omic methods and gene editing technologies (such as CRISPR/Cas9) would be desirable. • Experience in carrying out both independent and collaborative research. Proven experience with protocol development and research leadership. Excellent organizational skills and the ability to maintain meticulous records. • Ability to plan and prioritize own work in order to meet deadlines, including using initiative to plan research programs. Working collaboratively with others and building working relationships with stakeholders at all levels. Demonstrates inclusivity and respect for all. Commitment to personal development and updating of knowledge and skills.