Postdoctoral Fellows in the Hill Lab at the Francis Crick Institute

Postdoctoral positions are available in the laboratory of Dr Caroline Hill at the Francis Crick Institute (https://www.crick.ac.uk/) which is a world class interdisciplinary biomedical Institute situated in central London.

Work in the Hill lab is focused on understanding how TGF-β signalling pathways function normally in early vertebrate development and in adult untransformed cells, and how these signalling pathways are perturbed in disease, in particular, cancer. We have been exploiting the very powerful combination of early vertebrate developmental systems (zebrafish embryos), together with a variety of tissue culture systems and mouse models, and we use methodologies ranging from developmental and cell biology to computational modelling.

I am looking for highly motivated postdocs with proven research abilities and excellent publication records. The projects will focus on the question of how the combination of Nodal and Fgf/Erk signalling specifies cell fates, in particular, how it is involved in the decision governing the specification of mesodermal versus endodermal fates. We are exploring this in the zebrafish embryo and using human 2D and 3D gastruloids.

For further details about the projects, please contact Dr Caroline Hill (e-mail: caroline.hill@crick.ac.uk)

Here are two links through which you can apply for the positions:

https://crick.wd3.myworkdayjobs.com/External/job/London/Postdoctoral-Fellow–Hill-lab_R1365-1

https://crick.wd3.myworkdayjobs.com/External/job/London/Postdoctoral-Fellow–Hill-lab_R1364-1

Recent Hill lab papers

• Wilcockson, S.G., Guglielmi, L., Rodriguez, P.A., Amoyel, M. & Hill, C.S. (2023) An improved Erk biosensor detects oscillatory Erk dynamics driven by mitotic erasure during early development. Dev Cell in press.
• Economou A. D., Guglielmi L., East P., Hill C. S. (2022) Nodal signaling establishes a competency window for stochastic cell fate switching. Dev Cell 57, 2604-2622.e5.
• Guglielmi, L., Heliot, C., Kumar, S., Alexandrov, Y., Gori, I., …. Hill, C. S. (2021). Smad4 controls signaling robustness and morphogenesis by differentially contributing to the Nodal and BMP pathways. Nat Commun. 121, 6374.
• van Boxtel, A.L., Economou, A.D., Heliot, C., Hill, C.S. (2018) Long-Range signaling activation and local inhibition separate the mesoderm and endoderm lineages. Dev Cell 44, 179-191 e175.