Cellular responses to fluid forces: Phases across the ages

Water is essential for life and the most abundant molecule in the human body, accounting for more than 50% of body weight. Around 15–20% of this is extracellular, mainly interstitial fluid. These fluids, and the hydrostatic pressures they exert, are central to cellular processes in development, inflammation, regeneration, and homeostasis. Fluid forces and phases therefore play vital roles across biology.

This project will uncover how fluids influence biological structures and functions across scales, and how ageing alters these interactions. By combining intrinsic cellular ageing with ageing-induced changes in the microenvironment, we will explore how these stressors impair cellular capacity to respond to stimuli.

Research Challenge

The key challenge is to decipher the heterogeneity in how dynamic fluids influence cells. Such parameters have been difficult to study, but recent advances now allow us to do so. We will combine bioimaging, modelling, and advanced imaging platforms to analyse dynamic cellular behaviours at single-cell resolution.

Location

You will conduct your studies predominantly within the recently opened IRR in Edinburgh with state of the art research facilities. You will be based in a collaborative team based supportive interdisciplinary environment.

Please feel free to reach out, if you have any questions.

Deadline Dec 15th.

More info in the Eastbio link.