the community site for and by developmental biologists

About: AlessandroDonada

Biography:
Post-doctoral researcher in Paris, in love with science, stem cell, blood, and rugby. You can also find me on Twitter (@BioRugby)
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Posts by AlessandroDonada:

Research Highlight #5: Leukemic stem cells from iPSCs

Posted by on June 9th, 2020

Today let’s delve into a curious case involving induced pluripotent stem cells (iPSCs) and leukemic stem cells (LSCs). Most blood cells derived from iPSCs are unable to engraft in immunodeficient mice. However, Wesely and colleagues observed an exceptionally high engraftment efficiency of cell lines derived from an individual affected by acute myeloid leukemia (AML). In[…]

Research Highlight #4: Macrophages in human development

Posted by on June 1st, 2020

Today we return our interest to human development, focusing on a special blood cell: the macrophage. Produced in multiple, stem cell-independent waves, macrophages colonize the developing foetus early on, forming several tissue-resident populations. This includes the microglia which are essential for brain and spinal cord development. In this paper, the authors looked into macrophage development[…]

Research Highlight #3: IL-1 regulates haematopoietic stem cell pool size via PU.1

Posted by on May 25th, 2020

Today, we move to mouse adult haematopoiesis, with an elegant work on inflammation and stem cell biology. As always, feedback is more than welcome! Chronic inflammation is one of the classic events underlying aging and infection response. When associated with loss of quiescence in haematopoietic stem cells (HSCs), it is commonly the initiating event in[…]

Research Highlight #2: Blood stem cells heterogeneity arises from accessible chromatin

Posted by on May 18th, 2020

Hi there! Today’s highlight is focusing on a major question for the haematology community: what is causing blood stem cell heterogeneity? Please do not hesitate to let me know your thoughts in the comments here or on Twitter (@BioRugby)!   Highlight #2: Chromatin accessibility is the main source of heterogeneity in foetal haematopoiesis We have[…]

Research Highlight #1: Inhibition of cell cycle regulators alters the EHT

Posted by on May 12th, 2020

Hello everyone! My name is Alessandro, I am a postdoc in love with science, stem cells and blood! I am also a big fan of the Node, The Company of Biologists generously granted me a travel grant back in 2016, that allowed me to discover the beautiful Cambridge (the old one). As the lockdown starts[…]

Paris – Cambridge – Paris: a Megakaryocyte story

Posted by on November 14th, 2016

The first news came as a shock: so the British Railways are not always perfectly on time? For an Italian, that was a massive cultural shock. The second one was even more surprising: English weather is not that bad; actually, it is better than Parisian weather. But still, I was unable, on the train from Paris to Cambridge, to stop thinking about how[…]